ID   U4LK59_PYROM            Unreviewed;      1257 AA.
AC   U4LK59;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=RNA-dependent RNA polymerase {ECO:0000256|RuleBase:RU363098};
DE            EC=2.7.7.48 {ECO:0000256|RuleBase:RU363098};
GN   ORFNames=PCON_13329 {ECO:0000313|EMBL:CCX32489.1};
OS   Pyronema omphalodes (strain CBS 100304) (Pyronema confluens).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC   Pezizales; Pyronemataceae; Pyronema.
OX   NCBI_TaxID=1076935 {ECO:0000313|EMBL:CCX32489.1};
RN   [1] {ECO:0000313|EMBL:CCX32489.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS100304 {ECO:0000313|EMBL:CCX32489.1};
RC   TISSUE=Vegetative mycelium {ECO:0000313|EMBL:CCX32489.1};
RX   PubMed=24068976; DOI=10.1371/journal.pgen.1003820;
RA   Traeger S., Altegoer F., Freitag M., Gabaldon T., Kempken F., Kumar A.,
RA   Marcet-Houben M., Poggeler S., Stajich J.E., Nowrousian M.;
RT   "The genome and development-dependent transcriptomes of Pyronema confluens:
RT   a window into fungal evolution.";
RL   PLoS Genet. 9:E1003820-E1003820(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517,
CC         ECO:0000256|RuleBase:RU363098};
CC   -!- SIMILARITY: Belongs to the RdRP family. {ECO:0000256|ARBA:ARBA00005762,
CC       ECO:0000256|RuleBase:RU363098}.
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DR   EMBL; HF935890; CCX32489.1; -; Genomic_DNA.
DR   AlphaFoldDB; U4LK59; -.
DR   STRING; 1076935.U4LK59; -.
DR   eggNOG; KOG0988; Eukaryota.
DR   OMA; YDERITM; -.
DR   OrthoDB; 2735303at2759; -.
DR   Proteomes; UP000018144; Unassembled WGS sequence.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProt.
DR   InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR   PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR   PANTHER; PTHR23079:SF14; RNA-DEPENDENT RNA POLYMERASE; 1.
DR   Pfam; PF05183; RdRP; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU363098};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU363098};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW   ECO:0000256|RuleBase:RU363098};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363098}.
FT   REGION          136..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..152
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1257 AA;  140867 MW;  B1E34C3E959A490B CRC64;
     MPMPIPIPVP MSIPVPVPIP TTAPCEPGEP GEPGVAPAVS LSRHSVPRSI QYPDLSHLET
     ASTNWFGRDG EYRTGSGVQV DQVAVVGNVN YTSSTASTVP RRARRVSTES LAELPAAATG
     RVNGFWRNFG LSSIWQGGGR SQGSQQPQQQ EQLHGNEEEE QPEQLQISRQ NLQHLQRSLS
     VDSRHISDEE IPTELASPLV DRHLQHEIDS QLSHEADLHL VEEEASDDAL SLSSTSLHSP
     QAARSDESDY GYTPSLDLAF RECCQPEIAT KPRPYGFMTF FLDYEMTRLG LTLGLSLDDC
     YIRIPTLADR WYNKFYSART AGELWGMMEE FSKELCPDLQ QNDKGNDNGR GVPLTPFSET
     VWLHFRTSLS WPTNLELGGT IIISPDLETE PHFNPRITLI PLGLKTTTTK FAATFGADRF
     LVIKIPIVMG KMSERVKKRL DSWKLKLMGR NWRYYWSKTG MDSRNKNVNS VRRYWLHAYF
     FAESGVGLKK KNKEEGEEDE ASSMEEEMEG IKRPLIRREM TRDELIRWHM PIEKHLGNRY
     GKIWSRISLG LTAVKPTVTF TPDQILDIED TFGSLPPRGP QERAIMNDGC AICSPEVMRR
     VADYLDLEEI PSAVQARLGG AKGMWFLDPS ADPASKEIYI HVTASQRKFA RHDSEKAEDW
     ARSTLFVRGY SKKLSPSRLN SQLIPIMAIQ GVPFEVFKEL LEQHIGSELG GLLDATQDRV
     SLRYWISQNL MARQKHRDIP HFEGGTPRGY DERITMLLDA GFEPRKCRIL VEWISKIFNE
     RYKNVQDNTH ISVPLSTTAF CIADPTGTLE EGEVVLQFSE GFLDTGTKTR IHYLQGDVLV
     ARSPALLPTD IQKVRAVLPP SESGLSALKD VIIFSSKGVY PLASMLSGGD YDGDKPFICW
     DPRLVDPFTN NRSFAAFSSW DSSKYFQHFD CPLGELPSIG GAAGNSGLND FFQAGFESDT
     RSSYLGLCNN ILENYCCHHL PNGGWDKQAL YFAKLCAVMV DAQKQGLSPT TGVVADLFNW
     QRKLPRAEYR LPSSTNDVTE GLGEVDHILN RLILGVAREV AGKKMAEWKA IENSHAENPD
     LDLTAMYKRI DAAAFHDPGL RRILVKLNKD IDTVHKAWVG SFTHDLREDK NQVKAVVPRI
     AKLFHGIRPD VKEDIRLAAW FGGGTTGGMM ALTREWELLR ASALFYGKHQ WNWTFIWYVA
     ARELCGLKAR AAGIGGGGVS SRVVTGDVYY TLRPDARLVR NLEMLGDDGS ESSEMSD
//