GenomeNet

Database: UniProt
Entry: U4LNN4_PYROM
LinkDB: U4LNN4_PYROM
Original site: U4LNN4_PYROM 
ID   U4LNN4_PYROM            Unreviewed;       301 AA.
AC   U4LNN4;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   08-MAY-2019, entry version 20.
DE   SubName: Full=Similar to Probable 3-hydroxybutyryl-CoA dehydrogenase acc. no. P45856 {ECO:0000313|EMBL:CCX33197.1};
GN   ORFNames=PCON_14237 {ECO:0000313|EMBL:CCX33197.1};
OS   Pyronema omphalodes (strain CBS 100304) (Pyronema confluens).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC   Pezizales; Pyronemataceae; Pyronema.
OX   NCBI_TaxID=1076935 {ECO:0000313|EMBL:CCX33197.1, ECO:0000313|Proteomes:UP000018144};
RN   [1] {ECO:0000313|EMBL:CCX33197.1, ECO:0000313|Proteomes:UP000018144}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 100304 {ECO:0000313|Proteomes:UP000018144};
RC   TISSUE=Vegetative mycelium {ECO:0000313|EMBL:CCX33197.1};
RX   PubMed=24068976; DOI=10.1371/journal.pgen.1003820;
RA   Traeger S., Altegoer F., Freitag M., Gabaldon T., Kempken F.,
RA   Kumar A., Marcet-Houben M., Poggeler S., Stajich J.E., Nowrousian M.;
RT   "The genome and development-dependent transcriptomes of Pyronema
RT   confluens: a window into fungal evolution.";
RL   PLoS Genet. 9:E1003820-E1003820(2013).
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DR   EMBL; HF936032; CCX33197.1; -; Genomic_DNA.
DR   STRING; 337075.U4LNN4; -.
DR   OMA; MAHPMGP; -.
DR   OrthoDB; 938257at2759; -.
DR   Proteomes; UP000018144; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR   InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   PIRSF; PIRSF000105; HCDH; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00067; 3HCDH; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018144};
KW   NAD {ECO:0000256|PIRSR:PIRSR000105-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018144}.
FT   DOMAIN       21    200       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      203    299       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   NP_BIND      25     30       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING      49     49       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     108    108       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     113    113       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     135    135       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     160    160       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     291    291       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   SITE        157    157       Important for catalytic activity.
FT                                {ECO:0000256|PIRSR:PIRSR000105-1}.
SQ   SEQUENCE   301 AA;  32501 MW;  45EED70163DD5FE2 CRC64;
     MLPRHIARRF YSAQSAPVRR LAVIGAGQMG LGIALVAAKV SQVPVTLIDN NQSSLDKSLT
     FMSRLLEKDV SKQRLTASEA EAVQQRVLTT RDLAAVSEAD FIIEAVPEIP ALKKDIFSRL
     AENAPKDAIL ATNTSSISIT SIAAAAIGAE NRVVATHFMN PVPVQKGVEI ISGLQTSQET
     LDRAVAFVKT MGKIPSVSKD TPGFLANRIL MPYINEAIIC LETGVGEKED IDAIMKNGTN
     VPMGPLTLAD FIGLDTCLAI MKVLYEDTGD SKYRPSVLLK KYVDAGWLGK KSGRGFYDYS
     K
//
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