ID   U4LRX6_PYROM            Unreviewed;      1167 AA.
AC   U4LRX6;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   RecName: Full=Pro-apoptotic serine protease NMA111 {ECO:0000256|ARBA:ARBA00020338};
DE   AltName: Full=Pro-apoptotic serine protease nma111 {ECO:0000256|ARBA:ARBA00021524};
GN   ORFNames=PCON_03482 {ECO:0000313|EMBL:CCX34289.1};
OS   Pyronema omphalodes (strain CBS 100304) (Pyronema confluens).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC   Pezizales; Pyronemataceae; Pyronema.
OX   NCBI_TaxID=1076935 {ECO:0000313|EMBL:CCX34289.1};
RN   [1] {ECO:0000313|EMBL:CCX34289.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS100304 {ECO:0000313|EMBL:CCX34289.1};
RC   TISSUE=Vegetative mycelium {ECO:0000313|EMBL:CCX34289.1};
RX   PubMed=24068976; DOI=10.1371/journal.pgen.1003820;
RA   Traeger S., Altegoer F., Freitag M., Gabaldon T., Kempken F., Kumar A.,
RA   Marcet-Houben M., Poggeler S., Stajich J.E., Nowrousian M.;
RT   "The genome and development-dependent transcriptomes of Pyronema confluens:
RT   a window into fungal evolution.";
RL   PLoS Genet. 9:E1003820-E1003820(2013).
CC   -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC       {ECO:0000256|ARBA:ARBA00002558}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family.
CC       {ECO:0000256|ARBA:ARBA00010541}.
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DR   EMBL; HF936511; CCX34289.1; -; Genomic_DNA.
DR   AlphaFoldDB; U4LRX6; -.
DR   STRING; 1076935.U4LRX6; -.
DR   eggNOG; KOG1421; Eukaryota.
DR   OMA; PRHRLIN; -.
DR   OrthoDB; 1779375at2759; -.
DR   Proteomes; UP000018144; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 2.30.42.10; -; 3.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR   InterPro; IPR025926; PDZ-like_dom.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   PANTHER; PTHR46366:SF1; PDZ DOMAIN-CONTAINING PROTEIN C1685.05; 1.
DR   PANTHER; PTHR46366; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR   Pfam; PF12812; PDZ_1; 1.
DR   Pfam; PF13365; Trypsin_2; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
PE   3: Inferred from homology;
FT   DOMAIN          515..591
FT                   /note="PDZ-like"
FT                   /evidence="ECO:0000259|Pfam:PF12812"
FT   REGION          1..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..34
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..71
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1167 AA;  127019 MW;  6E13A23884AE00E7 CRC64;
     MSSRRASIIQ QDTEVPTQPT KNPLPENIIK TPQIPTPDSA HRHKPSRDDS SYFPPQATAG
     SPPTTWAAVN TVPPKPTIAA PVATPTPGEQ PTRAANETLE KKPVLPATPS LENPPTNDES
     IEPIPHPKVA TLAGLESLVS PKPSLSRSVS VISLASSIGA GTSASDKETW DRTLSRVING
     IVSIKATTTR PFDTESAGDY TATGFIISKK HGLILSNRHV VNPAPITCVA VFVNYEEVPI
     WPVYRDPVHD FGIFRYNPNA LKHHAVEEIE LHPGAAHVGE EIRVVGNDAG EKLSILGSTL
     ARLDRHAPSY GVDSYNDFNT FYMQAASGTS GGSSGSPVLN IHGHAVALNA GGSNSSQSSF
     YLPLHRVVRA VEKIKRGHHV SRGTLQTEFL HKSYDELRRL GMSEAQEEEC RARFPAETGL
     LSVIRVLRGG PASPQRKGAP TEDKVVNGIT QVPGLEPGDI LFACNGKHIT DFVGLWEIID
     DAVDQEITLD ILRAGKNGGS SQMLRVVPKV QDLHSITPSR FLEIGGATFH DMSYQIGRNH
     NCELESGVFC AASGFLLWSS WSRDFLVTAV DGKATKTLDQ FIDVIRSLPD HKRIPVMTRR
     LGNTDEHIMM VDVDRHFFLA ALFERNDVTG TWTRRELESA PVEAVVPAIV SGPSSEAEED
     DDAETVALDK IKSALVNVVC RLPYSVFGNT SASNYSGVGL IVATDPMPLV VFDRTAVPTE
     MLDMRLTVSN KSFPGRVVHL GAFAIVTFDR SLLPADVTVP EWDSVPLKVR DEVRTIGLTN
     DQLLVTKDSA ISSIGMNFNT KQCNPPRHRL INVENINLLE APSCWGGVIC RKPAAGSHDY
     KVSAFFMAVS SQNRNGEDVC WTQGCDVQRY ILPIVSKLTA GGELPPVEPT TRSLAVEFAD
     MPLSTVSTMG LSAERFKGFV RAAKKFRGNP RPLVVETHLR PLPAGVDEDT TLRIADIVLE
     IEGKPIYRVS ELTELDLEHK ETVEVVVLRG RKELRLTVPT VESWKTSGST IVQFFGAILH
     STHAAALEQV APNATLVPLN SSGVYVGGVS YGSPALDNVR PTHWILEVDG TPVATVDDVI
     GLLKEKRWKE GDYVRIKQVS RKGITSVVSV RADERWWPGL CWRRNGEGLG GRALWVQERC
     SGAEYVEKDG IPRITAPSTP VNSAGEK
//