ID U4LYC3_PYROM Unreviewed; 1472 AA.
AC U4LYC3;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10 {ECO:0000256|ARBA:ARBA00015369};
DE AltName: Full=Carboxypeptidase Y receptor {ECO:0000256|ARBA:ARBA00031354};
DE AltName: Full=Sortilin VPS10 {ECO:0000256|ARBA:ARBA00031250, ECO:0000256|ARBA:ARBA00031902};
GN ORFNames=PCON_04346 {ECO:0000313|EMBL:CCX34828.1};
OS Pyronema omphalodes (strain CBS 100304) (Pyronema confluens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC Pezizales; Pyronemataceae; Pyronema.
OX NCBI_TaxID=1076935 {ECO:0000313|EMBL:CCX34828.1};
RN [1] {ECO:0000313|EMBL:CCX34828.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS100304 {ECO:0000313|EMBL:CCX34828.1};
RC TISSUE=Vegetative mycelium {ECO:0000313|EMBL:CCX34828.1};
RX PubMed=24068976; DOI=10.1371/journal.pgen.1003820;
RA Traeger S., Altegoer F., Freitag M., Gabaldon T., Kempken F., Kumar A.,
RA Marcet-Houben M., Poggeler S., Stajich J.E., Nowrousian M.;
RT "The genome and development-dependent transcriptomes of Pyronema confluens:
RT a window into fungal evolution.";
RL PLoS Genet. 9:E1003820-E1003820(2013).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment. {ECO:0000256|ARBA:ARBA00025569}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Prevacuolar compartment membrane
CC {ECO:0000256|ARBA:ARBA00004488}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004488}.
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DR EMBL; HF936636; CCX34828.1; -; Genomic_DNA.
DR STRING; 1076935.U4LYC3; -.
DR eggNOG; KOG3511; Eukaryota.
DR OMA; ATMSEFI; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000018144; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 2.
PE 4: Predicted;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022927}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1472
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004652046"
FT TRANSMEM 1356..1377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1398..1427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..673
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 709..1344
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
SQ SEQUENCE 1472 AA; 165461 MW; C0AF63E906294CC1 CRC64;
MRPQSCLLLL AATLLPSGAF AGKPKLSETK FDNEPGALFY FEDSSTLLEL DAQARDVWRS
TNDGKEWKKL DEAKGKAVDV MEHPFDKEKA IILTAEKEHY VTSDKGETWR KFSVELPPSV
RQLPVVFNAK NPDYVMYNGR DCEKWDFIGL NCKDKTYYTK DWFKSDPKLL VENTHMCTFA
RGNKLFDQAE DATTLCIVDG KNKLPESRKL MISHDFFANS EEPKLDGQNT VQGVAGIASV
TKFLVAAVRS IGSDEMALYV SNDAKTWDRA EFPQDHGGLK EDAYTILEST PYSIQVDVLN
TGPLRGPMGE LFTSNSNGTY FTRNIENTNR ITKGLVDFEQ IAGIDGIVMA NVIQNADEVK
KSYKVTKKLQ SKISFDDGKA ETWKDLKTGS DKLHLHSVTE LNNLGRVFSS RAPGVLMGVG
NTGDILKDYN DGDLYVSEDA GLTWTKTRDG AHKYEFGGSG SIIIAVFDEG FTNKVSFSKN
HGKDWEDFDL GMDIRAKILT TTPDSTSLKF ILVGETKDHK THIFALDFED IFDGKKCNLD
KDHEDKSDYE KWYARLDNDG KPDCLMGRKQ FFWRRKKDAN CNAGELYKEP DAEVEVCECT
DQDFECDFNF VKTKDGKCEV APNTKLPIPA DQCKNPKDKY MGSSGYRKIP GNSCKGGKDL
EKKVEHECKD AISTPSTGKI FSKSNEFKAK LSLEYFYLDT AETAASEEET IIMMTEKQEL
FVSHDGGKEW KQILKDVKVI AVYPHPYQYN HVYFVTNTKK IHYTTDRAHN FNEIEAPLMP
NRKNLPFLEF HPRKPSWFIW HGEKDCTSSL HCHTSTFYTK SGGEDWKSLK TYTGMCRWVR
GQREQTAESL IFCEHEAKEG DDNSDTMELI SSTNFFDDET KHFDKIIGFA SMQEFLVVAG
VKEDNSLKAS ASIDGKSFAD AHFPYGFNVP HQTAYTVLDS VTHSVLLHVT VNDQRGFEFG
SLLKSNSNGT NYVLSLDAVN RNSDGFVDFE KMQSLEGIAI ANRVENWKDA LKGTKKKLRT
MITHNDGGQW KYITPPEKDA EGKPYSCSGN LEKCSLNLHH YTERTDPRHT FSSGSAIGLM
LAVGNVGDEL KGFADGDTFM TTDGGHSWKE VKKGQYLWEF GDQGSIIVIV DRSKATDVVH
YTLNEGKDWQ EYKFGEKLKI TDISTVPADN SRKFLLWGYK EGGREKFSTV HLDFTGITNV
QCILDDSSGT ESETDDFFLW SPSNANQADS DSCLFGHVAQ YHRKLPDHRC FIGRKLERFH
STLKNCSCTP EDYECDFNYQ RASDGTCKLV AGLDPPDHKK EMCAAKDAVE YFLPTGYRRL
PMTTCEGGRE LDKMESLPCP GKDEEYNKKH GGLGGFGLFM AIVIPIGAAA GVGYWVWTRV
LGNHFGAIRL GEERENRVVE YLIIGVSGVV AVVLAVPSIL AAIGGWIGRV TQRWRGGQRR
YTTRSSLRGR GEYSIVADDE GELLGDSDEE DV
//
