ID U4THN5_9LACO Unreviewed; 515 AA.
AC U4THN5;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=L248_2462 {ECO:0000313|EMBL:ERL63674.1};
OS Schleiferilactobacillus shenzhenensis LY-73.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Schleiferilactobacillus.
OX NCBI_TaxID=1231336 {ECO:0000313|EMBL:ERL63674.1, ECO:0000313|Proteomes:UP000030647};
RN [1] {ECO:0000313|Proteomes:UP000030647}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LY-73 {ECO:0000313|Proteomes:UP000030647};
RX PubMed=24265500;
RA Lin Z., Liu Z., Yang R., Zou Y., Wan D., Chen J., Guo M., Zhao J., Fang C.,
RA Yang R., Liu F.;
RT "Whole-Genome Sequencing of Lactobacillus shenzhenensis Strain LY-73T.";
RL Genome Announc. 1:e00972-e00913(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; KI271622; ERL63674.1; -; Genomic_DNA.
DR AlphaFoldDB; U4THN5; -.
DR STRING; 1231336.L248_2462; -.
DR eggNOG; COG0827; Bacteria.
DR HOGENOM; CLU_025185_0_0_9; -.
DR Proteomes; UP000030647; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR019410; Methyltransf_16.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; MODIFICATION METHYLASE HINDII-RELATED; 1.
DR Pfam; PF07669; Eco57I; 1.
DR Pfam; PF10294; Methyltransf_16; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 159..261
FT /note="Type II methyltransferase M.TaqI-like"
FT /evidence="ECO:0000259|Pfam:PF07669"
SQ SEQUENCE 515 AA; 58106 MW; A23C4D1CBEC23491 CRC64;
MEDIVMLEIG QDAAELRKRI AASTKEFVDM LNRPEQKAIG QFTTPAAVAD YMADRLLANW
KPANASAPIH ILDPGAGTGV LGLALAEKLF SQYPAAQVTL TAYENDPMAA KVLQQNLATT
QAWAKEHQLS FAFTVRMDDY ILDHAENPEA FIQHDTDTYD LVIANPPYKK LRKDSPEAKA
MHVIVYGAPN LYGFFWAKTA IEIKKHGLSA FIIPRSWMSG AYFYRLRNFM LAEGSLMEIH
SFKERTNIFG TTKVMQELVI VLFYKGGLDH IRFWQLPDIR QLGQGQAVDV PTYQAVTGAE
KRVYNLATAA DLHALKWAQS LSSTFAHTCL RMKTGLTVAY RNKEFLVQEP QVNTAPIFFA
DNLRHHTVKI GRKGPQFLKA ARSGLLQTNM DYIFIKRFST KEEPRRIQTA YYSAADYPVY
REISTDNKLD FVIVTNLNLA ILRGAFLVLS STQFDRYYRL VNGNTQVNAT EVNDMKFPND
QQLAALAEQF SVDDLKTLTQ HQIDAIVDEH FPGGL
//