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Database: UniProt
Entry: U4THN5_9LACO
LinkDB: U4THN5_9LACO
Original site: U4THN5_9LACO 
ID   U4THN5_9LACO            Unreviewed;       515 AA.
AC   U4THN5;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=L248_2462 {ECO:0000313|EMBL:ERL63674.1};
OS   Schleiferilactobacillus shenzhenensis LY-73.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Schleiferilactobacillus.
OX   NCBI_TaxID=1231336 {ECO:0000313|EMBL:ERL63674.1, ECO:0000313|Proteomes:UP000030647};
RN   [1] {ECO:0000313|Proteomes:UP000030647}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LY-73 {ECO:0000313|Proteomes:UP000030647};
RX   PubMed=24265500;
RA   Lin Z., Liu Z., Yang R., Zou Y., Wan D., Chen J., Guo M., Zhao J., Fang C.,
RA   Yang R., Liu F.;
RT   "Whole-Genome Sequencing of Lactobacillus shenzhenensis Strain LY-73T.";
RL   Genome Announc. 1:e00972-e00913(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR   EMBL; KI271622; ERL63674.1; -; Genomic_DNA.
DR   AlphaFoldDB; U4THN5; -.
DR   STRING; 1231336.L248_2462; -.
DR   eggNOG; COG0827; Bacteria.
DR   HOGENOM; CLU_025185_0_0_9; -.
DR   Proteomes; UP000030647; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR019410; Methyltransf_16.
DR   InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR   PANTHER; PTHR33841:SF5; MODIFICATION METHYLASE HINDII-RELATED; 1.
DR   Pfam; PF07669; Eco57I; 1.
DR   Pfam; PF10294; Methyltransf_16; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          159..261
FT                   /note="Type II methyltransferase M.TaqI-like"
FT                   /evidence="ECO:0000259|Pfam:PF07669"
SQ   SEQUENCE   515 AA;  58106 MW;  A23C4D1CBEC23491 CRC64;
     MEDIVMLEIG QDAAELRKRI AASTKEFVDM LNRPEQKAIG QFTTPAAVAD YMADRLLANW
     KPANASAPIH ILDPGAGTGV LGLALAEKLF SQYPAAQVTL TAYENDPMAA KVLQQNLATT
     QAWAKEHQLS FAFTVRMDDY ILDHAENPEA FIQHDTDTYD LVIANPPYKK LRKDSPEAKA
     MHVIVYGAPN LYGFFWAKTA IEIKKHGLSA FIIPRSWMSG AYFYRLRNFM LAEGSLMEIH
     SFKERTNIFG TTKVMQELVI VLFYKGGLDH IRFWQLPDIR QLGQGQAVDV PTYQAVTGAE
     KRVYNLATAA DLHALKWAQS LSSTFAHTCL RMKTGLTVAY RNKEFLVQEP QVNTAPIFFA
     DNLRHHTVKI GRKGPQFLKA ARSGLLQTNM DYIFIKRFST KEEPRRIQTA YYSAADYPVY
     REISTDNKLD FVIVTNLNLA ILRGAFLVLS STQFDRYYRL VNGNTQVNAT EVNDMKFPND
     QQLAALAEQF SVDDLKTLTQ HQIDAIVDEH FPGGL
//
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