ID U4U166_DENPD Unreviewed; 619 AA.
AC U4U166;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=D910_03452 {ECO:0000313|EMBL:ERL86038.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL86038.1, ECO:0000313|Proteomes:UP000030742};
RN [1] {ECO:0000313|EMBL:ERL86038.1, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
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DR EMBL; KB631780; ERL86038.1; -; Genomic_DNA.
DR AlphaFoldDB; U4U166; -.
DR STRING; 77166.U4U166; -.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd13310; PH_RalGPS1_2; 1.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF368; RAS-GEF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742}.
FT DOMAIN 119..355
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 504..605
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 451..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 619 AA; 69501 MW; 1521DEC4896258B7 CRC64;
MLRYSEIPRD ISGDSLATLK ISENSDDIIP TTHCHVTNQP TDNNSHNGCV AKTSDSIRRK
SSAPIVSSGP GPAGCYYNYG NCLTSVPVHA KTQSLPNRAC HNACHQNYSC AVFDILRIPA
EDFAAQLTIL DWPVFFNIQP DELTSCGWNK KNKLNVAPNV VAFSRRFNHV SFWTVQEVLA
GATVKHRAET LAFFIRIAKK LYELNNLHSL FAVISALQSA SVYRLSKTWG SLPKKDKQTF
DKLAEVFSDE NNWANLRSHI ESLKLPCIPY LGLYLTDLVY IDMAHPHSGG LESQQRLFKM
NNILRIISNY QHSDYSHLTR IPHVQDYLNS IRYIEELQKF VEDDQYKLSL TLEPPSPAPS
SSNNSSKESV VLDPVALASL NLSPAKASSG SLRLQAVTAG SKFIPGHRKC RSLGTNIFTK
SYQVGSFDPK EVPKTLNLLD DSVLEDSRLT GLRRNNLPSP NSDLPLQASQ STEDNCTLLT
RLSEDEITSE ESLCSLQGCV RRKTVLKEGR KPTVSSWQRY WVQLWTGSLI YFSPKSFKGQ
ERSDFKRDPC KMVSLSGCQV FYNDGMLHQD SFQLVDHIRG NVYKFRVGTK HLAERWCLLL
QQAANGEPTP LPSNLMSFE
//
