ID U4U446_DENPD Unreviewed; 541 AA.
AC U4U446;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 08-NOV-2023, entry version 36.
DE RecName: Full=USP domain-containing protein {ECO:0000259|PROSITE:PS50235};
GN ORFNames=D910_06063 {ECO:0000313|EMBL:ERL88679.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL88679.1, ECO:0000313|Proteomes:UP000030742};
RN [1] {ECO:0000313|EMBL:ERL88679.1, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
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DR EMBL; KB632093; ERL88679.1; -; Genomic_DNA.
DR AlphaFoldDB; U4U446; -.
DR STRING; 77166.U4U446; -.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF905; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 1; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000030742}.
FT DOMAIN 135..541
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 44..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 541 AA; 61115 MW; 8229DA8D9C69508C CRC64;
MNGFPRNYSK DKKRSVDDQR FDNVFYGIPY DEEETSTVAF CNNKPLGQSS TPPGFQKQGK
EARKRIINKE NIKDSSFTLR KILETTSKSS SSQRNKLSKS CASKKRKLSD VMDDYQEEQV
YHATNGDIML DYNVATLLNM GNTCFLNSVL YALRFTPTFL HNLHHLLLDL NSINSKLKET
KTKTSSLGRN GSAVSGSSWR SASSKDLLSI GNDIIPKCKE QVVTEKLHGL FVIMNNLESK
GSFDPYQPEA LMQAMRDANP LFEGNHQQDA HEFFVEMLSC LRITCDRLSE QIEQNPDLIK
PPESTTNGNN GSKKWNPVRR SWKKQLKKKE KLVVKNNGTM ENDIAADESE DGLSPSSNGC
GDATKRKFGY NFIAEEFLGV SLHRTKCLEC EGVSELKEPF LEIQVPVHGK DEAEESNYND
SNIFGSLCVT SEKLCDQNKY YCEICNRYNE AQRTILYEKL PNVLVLHLKR FTTTLSGIQK
VNTYVPTPLE IKCFCETCAK VENTKTTPHR YQLSCVIMHL GASMASGHYI AYSRASGCQK
V
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