ID U4UA03_DENPD Unreviewed; 1155 AA.
AC U4UA03;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Transmembrane protein family 132 middle domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=D910_04186 {ECO:0000313|EMBL:ERL86780.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL86780.1, ECO:0000313|Proteomes:UP000030742};
RN [1] {ECO:0000313|EMBL:ERL86780.1, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the TMEM132 family.
CC {ECO:0000256|ARBA:ARBA00006166}.
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DR EMBL; KB631865; ERL86780.1; -; Genomic_DNA.
DR AlphaFoldDB; U4UA03; -.
DR STRING; 77166.U4UA03; -.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR026307; TMEM132.
DR InterPro; IPR031436; TMEM132_C.
DR InterPro; IPR031437; TMEM132_M.
DR InterPro; IPR031435; TMEM132_N.
DR PANTHER; PTHR13388:SF11; DETONATOR, ISOFORM E; 1.
DR PANTHER; PTHR13388; UNCHARACTERIZED; 1.
DR Pfam; PF16070; TMEM132; 1.
DR Pfam; PF15706; TMEM132D_C; 1.
DR Pfam; PF15705; TMEM132D_N; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1155
FT /note="Transmembrane protein family 132 middle domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004656021"
FT TRANSMEM 851..875
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 65..171
FT /note="Transmembrane protein TMEM132 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF15705"
FT DOMAIN 447..759
FT /note="Transmembrane protein family 132 middle"
FT /evidence="ECO:0000259|Pfam:PF16070"
FT DOMAIN 821..920
FT /note="Transmembrane protein TMEM132 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF15706"
FT REGION 813..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 997..1042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1021
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1155 AA; 126416 MW; BB840A2CE21CC933 CRC64;
MKGSHPVWII VALLAGLGLA VNVHFETKDG GFFLNQQPRQ HYPMMPEALA PLGGGVAAGG
TPLSVDRFTV LQSSQPISVR ATYGPFSTKQ TVPARYVVPD PVPFNSTGQG FELQDQATHH
LDMSAHIVPS EVPRDKPVLR VLFHTGTDPG GRRQVLLARH HQRVCIVLHA SMGQRPPLRA
ACSPEGEEGA CLAQITIPAS WWPPLTPPGH PDKPTKTPAR LVQVAYSVLE PWPEEGEGCR
PQMAVQPGVV LGQVPLAAAQ GAYKELKLTE AVRMLVPHPP LFPMSRLHVA VFLDRAKARD
VTAVVIRARV KSGIRLLDAT PSGVTAWNIT VEINARHTGA TVTLLRREPP EEDGATQSPA
ECVELFTWLL EVTEDEIYEG ARIVWTARFE PAQLEEQLFH SSAQRSDSRK FTTRFEIQKD
DIQAVVPISK NWEVLNTAVL TGQQVSQAMK VSSSCGSVYV DGSEQRGSMN ASVVVKYGTY
TGLARFTVWM PEFPLEVVVG DSRLSQLKSW RVPEYHPVRS VKSRRRKRAA APWGGAPDLE
ASGNMVERPL CRLRYQQTSV EVYAHFLATD HESGRVSYLV NRRTWLRVTE LVLPCLRVSD
PRIASLHGKV LQGRSMGRAE VQVLSPVTSR VYGSREVRVV NEKVGVTKMA VRVVTGLQLN
ISPDTSVENG YVAETSVTRK LTAQYQEGLL DIELEFSDGS RTALRDIADT DYHLVVESLD
PAVVAFAPMV ASHHPRVIAV GEGSGDLLQV TLLLPEECRT ASRTKAKPAG PLATAAAQIT
VDFSSAQPDI LQNDGSSKAG RDFGDLQDIL KGAAQKEEKS HEPHVQARQY QGNKGVTKNR
HAYSPLTPLE ISMYVLLAAF CCAIVVFVVS CVVYASKFKP MEAGVTAGVH ASPINATPHL
RKPRETTQNA HDWVWLGRAT MDPPSNRSSA VGQDMRIITN PLTLNYVEPD DSLATSFTNP
HHINLPATAV DSATYSRGSG GRMSNVVIED EVQAWSRPIP PPPLPPHAAP PKAPVEEYRP
PVPPHRNMQH HQRSEPAKST GSLVRDGCLR AGRASEAELD QSEETGEEEE VEGRPVFQFD
DEPAAEFVAN VAPPRSRTVA EVKRATVVGN PMCRTNQASE NEPEGVAPGE LPDHLGVDYD
QIMRYFDNLK ARPPI
//
