ID   U4UA25_DENPD            Unreviewed;       834 AA.
AC   U4UA25;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=TGF-beta family profile domain-containing protein {ECO:0000259|PROSITE:PS51362};
GN   ORFNames=D910_04205 {ECO:0000313|EMBL:ERL86800.1};
OS   Dendroctonus ponderosae (Mountain pine beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Curculionidae; Scolytinae; Dendroctonus.
OX   NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL86800.1, ECO:0000313|Proteomes:UP000030742};
RN   [1] {ECO:0000313|EMBL:ERL86800.1, ECO:0000313|Proteomes:UP000030742}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA   Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA   Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA   Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA   Birol I., Jones S.J., Bohlmann J.;
RT   "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT   a major forest pest.";
RL   Genome Biol. 14:R27-R27(2013).
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR   EMBL; KB631865; ERL86800.1; -; Genomic_DNA.
DR   AlphaFoldDB; U4UA25; -.
DR   STRING; 77166.U4UA25; -.
DR   Proteomes; UP000030742; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   CDD; cd13751; TGF_beta_GDF8_like; 1.
DR   CDD; cd13752; TGF_beta_INHB; 1.
DR   Gene3D; 2.60.120.970; -; 2.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 2.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848:SF292; INHIBIN BETA CHAIN; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 2.
DR   Pfam; PF00688; TGFb_propeptide; 2.
DR   SMART; SM00204; TGFB; 2.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 2.
DR   PROSITE; PS00250; TGF_BETA_1; 2.
DR   PROSITE; PS51362; TGF_BETA_2; 2.
PE   3: Inferred from homology;
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           36..834
FT                   /note="TGF-beta family profile domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004656039"
FT   DOMAIN          302..413
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
FT   DOMAIN          717..834
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
SQ   SEQUENCE   834 AA;  94352 MW;  C37B71B077BAD0A8 CRC64;
     MLSPLRPFAQ CRPPAALKFF LIISALPFTI DGAKSASGYS HQVQPQDEPL STSLFDMAYP
     SMPASPPTST CSLCKRREEL KVRNLAIIKE EILKRMGFSQ PPNITGKVLP QVPSHYMAKI
     EEEHGMQGDQ PYKTGLTYTE EDDEYHVRTQ KVLTWAETHP RMRHMSWKVN DVLHFPFSDS
     ITKFHVANAT LNFFVRGGSE RMAGPHDVLI DIYKVVKFGD HSEPPELVRV KSWKEPWLPG
     RGKWIQTDFT ATVGEWFKNG KENFGFVINA TVNGKKLAVT DFNSEKSKAP YVETAVMEPK
     RRKRRNSGLN CDEKANEPLC CRYSFYVDFV EIGLDFIVAP KRYDAHMCSG ECPYLTLQKY
     PHTHLLKMAQ PNSAAPCCAP RKMSAISMLY FDDKLNLVLS SLPGMVHDSK SPLGWTLSVA
     CLYLVLSTAS GSLANGERLR HHHMKNQLEK TAVLEASSKM PLLGCPNCLF KHDRDREKLE
     SDKLRLEAIK RQILQKLGLR AKPNVTHSLP KEVVMATLSR AEDGDFTGAF GENPDFPTTS
     EKSGNLDTVE ADDFYGRTSE IISFAEQGSW VNQNRLLQFQ VSPEAGSQMG QEFRVREASL
     WLKADLLKAP TSKCRSTDIF VFKIISNRLP ESQFDRLTAE PIAVPLEEAA SGWQKIDVTQ
     TVSEWLGERA KDKLSLFVDC SCCAHWRIHL FNEESDQRSN PNRPFLVIHT DPSTAKRVRR
     RAIDCSLDSG NQCCKQRFYV SFKALGWEDW VIAPQGYFAN YCRGDCGQHR TPDTFVTYHT
     HVIEEVRKTQ HLSGMTPCCA PLKFSTMSLI YYGPESTIIK RDLPKMVVEE CGCP
//