ID U4UBY9_DENPD Unreviewed; 432 AA.
AC U4UBY9;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 22-FEB-2023, entry version 41.
DE RecName: Full=Cytochrome b5 heme-binding domain-containing protein {ECO:0000259|PROSITE:PS50255};
GN ORFNames=D910_05509 {ECO:0000313|EMBL:ERL88121.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL88121.1, ECO:0000313|Proteomes:UP000030742};
RN [1] {ECO:0000313|EMBL:ERL88121.1, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
CC -!- SIMILARITY: Belongs to the cytochrome b5 family.
CC {ECO:0000256|RuleBase:RU362121}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362121}.
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DR EMBL; KB632028; ERL88121.1; -; Genomic_DNA.
DR AlphaFoldDB; U4UBY9; -.
DR STRING; 77166.U4UBY9; -.
DR OrthoDB; 3715892at2759; -.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR018506; Cyt_B5_heme-BS.
DR InterPro; IPR005804; FA_desaturase_dom.
DR PANTHER; PTHR16740; CYTOCHROME B5-RELATED PROTEIN-RELATED; 1.
DR PANTHER; PTHR16740:SF1; CYTOCHROME B5-RELATED PROTEIN-RELATED; 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF00487; FA_desaturase; 1.
DR SMART; SM01117; Cyt-b5; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR PROSITE; PS00191; CYTOCHROME_B5_1; 1.
DR PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU362121};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU362121};
KW Membrane {ECO:0000256|RuleBase:RU362121};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU362121};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW Transmembrane {ECO:0000256|RuleBase:RU362121};
KW Transmembrane helix {ECO:0000256|RuleBase:RU362121}.
FT TRANSMEM 164..182
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362121"
FT TRANSMEM 246..263
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362121"
FT TRANSMEM 275..293
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362121"
FT TRANSMEM 300..321
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362121"
FT DOMAIN 24..100
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
SQ SEQUENCE 432 AA; 49890 MW; 6F1ADF1A5645E5AD CRC64;
MDMSKVFRSS LGIKYPSLRD HPLHSAEKWL EGKSIDDGAE GYWRIHDHLY DLSGFIESHP
GGKDWIQLTK GTDITEAFES HHLSTNAEML LPSFLLRKAS SPRSFPFTFH ENGFYKTLKR
RIIKQMENLP ENPADRSKSL IDRIFSGYLT SFLLAVYFES FAIGAVSGIF LGLLTVAAHN
FFHQKDNFRR FYFDFSMMSS REWRVSHVLS HHMYTNTICD MEISSVEPFL QYLPGEKNLL
VRHGSWVYSF GFYAFLFLGH YLKTLAVNFL KGNSQFIWTA LLPFTIPFLS WMITGKSILI
CLLMYIWIIV IASIHFGIVG LNAAHHHPDI FHDGDTARPK EQMDWGLFQV DTVADRRDIT
GSHFLVLTNF GDHALHHLFP TVDHGHLEQF YPIFLETCVE FGVRWKFLTQ LDLVKGQYGQ
LARILPNKNP PN
//
