ID   U4UD59_DENPD            Unreviewed;       640 AA.
AC   U4UD59;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   RecName: Full=CRAL-TRIO domain-containing protein {ECO:0000259|PROSITE:PS50191};
GN   ORFNames=D910_05238 {ECO:0000313|EMBL:ERL87850.1};
OS   Dendroctonus ponderosae (Mountain pine beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Curculionidae; Scolytinae; Dendroctonus.
OX   NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL87850.1, ECO:0000313|Proteomes:UP000030742};
RN   [1] {ECO:0000313|EMBL:ERL87850.1, ECO:0000313|Proteomes:UP000030742}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA   Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA   Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA   Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA   Birol I., Jones S.J., Bohlmann J.;
RT   "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT   a major forest pest.";
RL   Genome Biol. 14:R27-R27(2013).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC       {ECO:0000256|ARBA:ARBA00005290}.
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DR   EMBL; KB632003; ERL87850.1; -; Genomic_DNA.
DR   AlphaFoldDB; U4UD59; -.
DR   STRING; 77166.U4UD59; -.
DR   Proteomes; UP000030742; Unassembled WGS sequence.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   CDD; cd17870; GPN1; 1.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR   InterPro; IPR004130; Gpn.
DR   InterPro; IPR030230; Gpn1/Npa3/XAB1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR21231:SF8; GPN-LOOP GTPASE 1; 1.
DR   PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR   Pfam; PF03029; ATP_bind_1; 1.
DR   Pfam; PF00650; CRAL_TRIO; 1.
DR   PRINTS; PR00180; CRETINALDHBP.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR   SUPFAM; SSF46938; CRAL/TRIO N-terminal domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030742}.
FT   DOMAIN          405..587
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000259|PROSITE:PS50191"
SQ   SEQUENCE   640 AA;  71777 MW;  B2D085A1C84DED90 CRC64;
     MAEAAAPEAK QEATKTPICL LVVGMAGSGK TSLVSRMAEG FHGAKPYAVN LDPACINLPY
     FANIDIRDTV NYKEVMKQYK LGPNGAIVTS LNLFSTKFPE VMGFIEKGNT THCVIDTPGQ
     IEVFAWSVSG SIITETLASA FPTVMLYVVD CVRSTAPATF MSNMLYACSI LYKTRLPFII
     CMNKVDIVDA SYAKDWMTDF ESFQEALEAD ESYVSSLTRS MALALDTFYQ DIRVCGVSAA
     TGEGMEELHK MIEECRIEYE TDYRAEMQRI KEESERKKQE TENDSTDVNS LIDVVPAGME
     LADVYLRNPA GDSSEDSEGE EEPFADTVDV DEENTFKKVL SGMETCMDAD RLYQQDPKLK
     KSDVEMLAMW SKQQRHFPRV EEVQIALALH ACFYSVEQAK SCLDNYLTIR GMCPQLFANG
     NPDKDPALKM AMSVNGFAIL PDKTKEGYTV LLTRLIDPNP DRYNPQVGSK VFDMLVLRHI
     HLVGPGNGLV VIIDMKGGVF GHLTKINLGE LKKFLIYLQT AMPIRLMAVH FINVVPFMDK
     IMAAIRPFIS KDMFLKLIIH ANNDNLFKYI PKEMLPEEYG GRAQSVDLLF EKCKQLIYDS
     LTFFEFQDTM ITDESKRIGP RKNADSLFGF DGSFRKLAVD
//