ID U4UH33_DENPD Unreviewed; 552 AA.
AC U4UH33;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Rap-GAP domain-containing protein {ECO:0000259|PROSITE:PS50085};
GN ORFNames=D910_06584 {ECO:0000313|EMBL:ERL89210.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL89210.1, ECO:0000313|Proteomes:UP000030742};
RN [1] {ECO:0000313|EMBL:ERL89210.1, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
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DR EMBL; KB632155; ERL89210.1; -; Genomic_DNA.
DR AlphaFoldDB; U4UH33; -.
DR STRING; 77166.U4UH33; -.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711:SF32; RAP GTPASE ACTIVATING PROTEIN 1, ISOFORM H; 1.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742}.
FT DOMAIN 88..304
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 349..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 508..542
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 376..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 552 AA; 60486 MW; 175531D23C55A741 CRC64;
MARKEHSNLI GTDENLGPVL LSIKTETMAQ QEHTRVLLRL RTATKHEIVP SAYLGPNPSP
SRMAKLLNEE VNVDNFQPVL HPKSSQLIAN YDEHVLVTTF KFGVLYQQFG QTTEEEIFCN
SVTSPAFDDF LSLLGQRIQL KDHKGYRGGL DIQNGHTGDT AVYEIFKERE VMFHVSTLLP
YTDNDPQQLQ RKRHIGNDIV AIVFQEENTP FCPDMIASHF LHAFIVVQVL DPNTPNTRYK
VSVTARDDVP FFGPTLPTPA IFKHGPEFKE FLLTKLINAE NACYKAEKFS KLELRTRTAL
LQSLIDDLKE KTADFLGGIP STAPGTPKGE SGPGARFIDT VKKAWSAAKV KTSQSDNNLG
PGSHHHHDKL GKKTSQPPIS ELTPSSGRSI SKSSIVSNSK KSGGSGSTGS GRSSTASSPD
LTAHASSNAR PALSEASDDS SLTSEDLEHL AGGYVDSDTG LESMSSAETA AKACSLCQDR
PDSGTSGGQG VSQQDALAQE VTRLKCDKLD LLRQNVSCQR DIKRLREKEL VLQGELAQAH
KEIMRLRELL KD
//
