ID   U4UIC0_DENPD            Unreviewed;       747 AA.
AC   U4UIC0;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=DNA polymerase eta {ECO:0008006|Google:ProtNLM};
GN   ORFNames=D910_09429 {ECO:0000313|EMBL:ERL92108.1};
OS   Dendroctonus ponderosae (Mountain pine beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Curculionidae; Scolytinae; Dendroctonus.
OX   NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL92108.1, ECO:0000313|Proteomes:UP000030742};
RN   [1] {ECO:0000313|EMBL:ERL92108.1, ECO:0000313|Proteomes:UP000030742}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA   Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA   Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA   Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA   Birol I., Jones S.J., Bohlmann J.;
RT   "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT   a major forest pest.";
RL   Genome Biol. 14:R27-R27(2013).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KB632310; ERL92108.1; -; Genomic_DNA.
DR   AlphaFoldDB; U4UIC0; -.
DR   STRING; 77166.U4UIC0; -.
DR   Proteomes; UP000030742; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProt.
DR   GO; GO:0006301; P:postreplication repair; IEA:UniProt.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.40.1170.60; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR   InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR041298; UBZ3.
DR   InterPro; IPR001126; UmuC.
DR   PANTHER; PTHR45873; DNA POLYMERASE ETA; 1.
DR   PANTHER; PTHR45873:SF1; DNA POLYMERASE ETA; 1.
DR   Pfam; PF00817; IMS; 1.
DR   Pfam; PF11799; IMS_C; 1.
DR   Pfam; PF21704; POLH-Rev1_HhH; 1.
DR   Pfam; PF18439; zf_UBZ; 2.
DR   PIRSF; PIRSF036603; DPol_eta; 2.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR   PROSITE; PS50173; UMUC; 1.
DR   PROSITE; PS51907; ZF_UBZ3; 2.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          8..239
FT                   /note="UmuC"
FT                   /evidence="ECO:0000259|PROSITE:PS50173"
FT   DOMAIN          604..638
FT                   /note="UBZ3-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51907"
FT   DOMAIN          682..716
FT                   /note="UBZ3-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51907"
SQ   SEQUENCE   747 AA;  83580 MW;  0B1C63ACB0407281 CRC64;
     MTHTDRIVLL IDMDCFFCQV EEKLNPDLKG KPLAVVQYNQ WRGGGIIAVN YPAREKGVTR
     HMRGDDAKEK CPEIVLVKVP DVRGKANLSK YRDAGKSVAE VLKTFTPLLE RASVDEAYLD
     ITSAVEKRIE LKEDVTTEKL LNTFVVGNAT GDFVENVTRH RAFDEANYRL AVGGIIAEEI
     RAEVFKVTGY RCSAGIAHNK LLAKLVCGLH KPNKQTILPH ESVPHLYEKT PVRKLTSLGG
     KFGNSIMEKL NIEYLGELSK FTQRELAKKF DEKSAAWLFN IAKGIDTEPV NTRLVAKSIG
     CCKKFPGKSA LCTKEDVEYW LNQFADEMAQ RLEQDLEENC RRAKQIVVNF GQSIGDEEMI
     NSKSHPLGSY EQRRIFETAL QIVQKNCQRA DGSFCIIYLG LSIGHFQDVK KVKEITSFFK
     AVTEKACEST SKSATESHNN NEHSCLDEEK CEKLADFSNT SDDADQSHND SLYSQMTEGD
     DVDYGSLVFY EQVHPESIVN QQVAGFESIA AGKDSDSSGD SISNEISFHK IEDSNNVEGR
     SSFFNRYFSG KGVRNFDTSK SLEGLDDSDE VSTELDSCSA VVSGEEKSDA VSSALVTGEM
     ADEADFTLKT CADCGKTVES QDYQSHLDYH FVISMVKSEA HLYKSEPVKQ QPTKKASKRK
     LRENPQQPIV NYFKNLSAQE PENPTDKICP ECNRNIPEAN WEVHADFHAA KRLHLEINST
     HSRAMKEDAA KPKIKGQKKL LGFLKSV
//