ID U4UML3_DENPD Unreviewed; 435 AA.
AC U4UML3;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial {ECO:0000256|ARBA:ARBA00017279};
DE AltName: Full=Complex I-42kD {ECO:0000256|ARBA:ARBA00032828};
DE AltName: Full=NADH-ubiquinone oxidoreductase 42 kDa subunit {ECO:0000256|ARBA:ARBA00032628};
DE Flags: Fragment;
GN ORFNames=D910_08599 {ECO:0000313|EMBL:ERL91265.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL91265.1, ECO:0000313|Proteomes:UP000030742};
RN [1] {ECO:0000313|EMBL:ERL91265.1, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000256|ARBA:ARBA00003195}.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000256|ARBA:ARBA00004305}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA10 subunit family.
CC {ECO:0000256|ARBA:ARBA00008606}.
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DR EMBL; KB632278; ERL91265.1; -; Genomic_DNA.
DR AlphaFoldDB; U4UML3; -.
DR STRING; 77166.U4UML3; -.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:InterPro.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031314; DNK_dom.
DR InterPro; IPR015828; NDUFA10.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10513; DEOXYNUCLEOSIDE KINASE; 1.
DR PANTHER; PTHR10513:SF15; NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 10, MITOCHONDRIAL; 1.
DR Pfam; PF01712; dNK; 1.
DR PIRSF; PIRSF000543; NADH_UQ_42KD; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Electron transport {ECO:0000256|ARBA:ARBA00022982};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW Respiratory chain {ECO:0000256|ARBA:ARBA00022660};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 107..338
FT /note="Deoxynucleoside kinase"
FT /evidence="ECO:0000259|Pfam:PF01712"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ERL91265.1"
SQ SEQUENCE 435 AA; 51104 MW; 44D69A2CFFF66BB1 CRC64;
GLYLFEVIHC NVNPVVNIRA LLHKRQIELR SLEMTSLIRI GVRKASLIAP RSLLVKINYQ
STRTITSRLD ELPPKPKPWP YNEKPYTNLQ YFFDKTTPRF DENTKLIIVE GPVASGKSKL
AKEIAKSFGM IYYPEANLDM QYINPYGYDL RQLDSMLPPS CKSFDVMDFM RNPNHMLVAR
WQIEQYMIKV SQYIDALAHL LSTGQGVVLD RCAFSDFVFV EAMYSQKYLS KPAYKKYYEF
RRSTIDHLLK PHLIIYLDVP VSKVLENVRQ RNISYEKNSP VFTQQYLEVM EKTYKQKYLK
EMSPNAELLV YDWTVEGDTD IVVEDVEAID FDKYDEQDSH FQDWNLPNEE EWGCVRSRYA
DQKEDILSYA NVQTYDVPEL LMSGEDSEIY FRVMDEAPGQ QYEFGYNKSM GDGGFLFKWD
RPTRSTLPLR ERRTV
//
