ID U4UQ65_DENPD Unreviewed; 7028 AA.
AC U4UQ65;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Microtubule-actin cross-linking factor 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=D910_09598 {ECO:0000313|EMBL:ERL92281.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL92281.1, ECO:0000313|Proteomes:UP000030742};
RN [1] {ECO:0000313|EMBL:ERL92281.1, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
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DR EMBL; KB632319; ERL92281.1; -; Genomic_DNA.
DR STRING; 77166.U4UQ65; -.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd00176; SPEC; 14.
DR Gene3D; 1.20.58.60; -; 27.
DR Gene3D; 3.30.160.780; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR Gene3D; 3.90.1290.10; Plakin repeat; 13.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF23; SHORT STOP, ISOFORM H; 1.
DR Pfam; PF02187; GAS2; 1.
DR Pfam; PF00435; Spectrin; 18.
DR SMART; SM00243; GAS2; 1.
DR SMART; SM00250; PLEC; 33.
DR SMART; SM00150; SPEC; 30.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR SUPFAM; SSF75399; Plakin repeat; 21.
DR SUPFAM; SSF46966; Spectrin repeat; 26.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS51460; GAR; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 6561..6596
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 6607..6642
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 6647..6719
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 1..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 699..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1549..1568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3752..3813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6429..6503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6825..7028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1686..1713
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3136..3163
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3839..3899
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4357..4388
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4432..4522
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4576..4603
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4687..4714
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5346..5391
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 6177..6204
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3774..3813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6429..6454
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6828..6853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6866..7013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7014..7028
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 7028 AA; 788743 MW; 9AB39F905695FB97 CRC64;
MQPQPFRTFR TEFHMSSASE HTSTYTTTTH YSKQFVQTTK SSSSSRSENG TTIKISENKQ
DQSTDETDKI ANGRPPDKHT TLTQIIQEGP QNWGTSMQFT EIKSLKRVHK VHEGIGTENI
TDIAGIINPY TGEQMTVRDA ILERILDVRT GTIIASPDGT QISIEEAKTR GLIEPKVADK
LQSPCGIKED GHELTLLEAI QKDIFEAEQG LIDPSEKRLK VSHSMTINQA IDDGKVDVTS
GTYRLESGGT IDIKEAYKRG YLLQHTEVKL QTEALALTDV ITQGLIDEVT GWIIDRNTGN
KYQIDAATKC NIVEGDLREI VEQKSDSKIT VLQALDRGII NPKLGKFVLG HEKVSLLEAK
RRQLIVKPKT LKEVVDDNLM DEEGKILSPL HQSRLTLLEA ANRGVLDIDQ VKCIVDFRTN
DLITLNDALR EGIILPEGKF RNSVTGETLT IQEAVSRGYI ISVVKKSIFD VDGFQPPDKS
DHISFNAAIA KGFISKKHDG SLLVNKKSGK LITFTEGIQS GQVKPEVHEM LTRGVGIYEN
RKELNVLEAV FKGHIDPKNG NLIDIKTNKV IYLKEAIAQH LITPEGAATL NSLLNLNVST
RITRTLVQRY VTVTSKDVKQ EIITYTEALR LGLINNEMQT FTDPITHQVI PIVQAISEGR
LAPDVDSSEK VIAPKSSAVI TIVSRKEVPI HRESMQIDQQ TVYSEKKSSE NIHRESMQVD
QQSLYSEKKS SEKQVYELPS EGWLLSDAIN QKLFDPVTGL FIIPGTDRLA SFEECVNLKL
ICSNSATVLD PISKRKMSIT KALDKKILDS TGHYRIGNEK LTIEEAINRG FIILEDSTQM
AESQRLLQIT KSEGQPPKVE VSAVLDKNPP VYTEVKIAQT GTAEPVELQP GIIYDPSINA
VVYPDKNQAV DLITAVLENK VSSDLVKVTD PFTGKPMEIK EAIRRNIVDP EKEQYRDKVG
QKMSLKDAAR FGIITVVGAP IAAVTSVVKT IKTLYVVNPK TGEKIPAEVA LQEGLIDLAT
YEKMQSELVE NSQPITTTTT VTRTSLKVTD AKTGKTYTSH EALEQGLITP QQMEELEQQN
KEKVKLLDTA TISLSDESGP SEADKTRARI TTEPTYRVKI GRAQSLSPDR EAKKVVLQKL
RRKIVRPEDA AKTGLLESEA VSLLADKANF ITEEGETLTL QEALEANKVD GNQGIIIDPQ
RGDQLTISQA IERGILDPDG SSEILVPLNR SLSIPEVIKQ GLLDPATQKV VHPETGAHLS
ISEAIICDII DPLSTLVEKT GDKVTLSEAL ESGVVDDETS VVETKSGAKN LEDAVKDKVF
DEATPKGPLQ LPPAGMTLSV AIKRGLVDSD TKHIINPVTK ESISISEAIK DNFIMSLPFP
PAPEGVKLDE ALESQLIDTD AGTFKDPKSG ETYPVSEAVE KGMLIIKEPT SAVYFSAKPP
VTTVTETVNT IHTVTTKTIE ILSGYALLNN QEVQNVTTGQ ILSIEEAKKQ GIIKDVKETK
NKTIIKDIHM SFSDALHKGL VDMKAGTYTD PNSGESIPIQ QALQEGKISA TPQITEESRE
SSVSTSKSTE LNISEAFETI YDSKSEKFLD LTENKEVTFK EALDRDIIDP NSIIYDVAAQ
KTISIAAAVD KGLIDSETGR IKDEKSGKSI DFKEATKKGL IAVLGGLALP VIAPVAAGVA
AVNAVKDYAE KKKLEKEKEV KKVQEERKAM TIQTVDSAQA KTSTVHVIKK EESIISSPDI
VKILPVGDAI SQNLINPKTC RIIYGNSELP YTVQDGLSQN KIGPLDEIQI VSNNRVILVD
VHKSAVISIS KNMTAQKLAE LGYYDLRRRL FIDPQTGAHI TFEDLVYELG VIDPDTVLVK
DLTKKPAAYV TLHEALQRPL LDRQTGYMVD PKTGKRVPFF EAVKLRWIIH VDDKPKEKFK
PITLQEIVKT EKFDHEKVEV ATATETLPLI KALNANIVDP KSVTIRDPKN MQLVPFYEAV
DKQIVDPQRG LVVNTATQEI IPFSEAFLSG LVLAIPRPIS LQAVIHKGMY DSESFKMRDP
LTNQLLSVQE AIERQIVDAK ISEIKDTKED VFIILDDAIA NKVIDAETGR MMDTNAGALV
PFDKALELQL IRTKPVVFNL LQVILANYYS PQSGLIMNPI TGDEITLAKA IEYKLVDPVT
TRIKDDRRGR IVEIHEAVES SLIDAEKGLL TNPPLTLDQA YLKGYILSTV LPWSLQETLA
QNVYDSTSGQ IVFNDSNVTI SQAIEGGIVN PNVLTVKDPK SGEIITLNEA IQLKLIDPVK
GQAYDPISNS EMNLVEAQER GLIVPYKTQI TLPEAVFKGF YDPTTGKFIN PKNKERLKAS
SAINRGYVDT SGTLVTIDEE IVTFDQAVTE GVIDTNEGFI LSYNEHVDFN EAFERGLLVE
IRPPIPLSEA IAKGIYDEET QLFLDPQTGQ YLTLIEAIEI SLIDAESVSV KDTRVGIWRK
ISLIDAIHNN YVDGNTGKVR DFAKGENFEV SLQKAFDMGI LVDNKAAISL QRAIHQGLYD
ETTGKILDPS TDRKVTLHEA IRNFNVNPLL PCYLDRREGR LYNLTETCRL GIIDKRSGTF
KEPFTEKTIK LTEALNAGLI VDIESANFGL AEALELGLYI PEEGVFVHPA SGRKFNLSES
IENELINPVT SLVKNSKLNK YVQLPVAIET RLIDDQLSTY VFPHGKTIDL IEARNKGLIV
TARTPLTLEE TLRNSLYRPD SGKFADPVNN EFYDLKQALE NKFIDSQTTA LKDATNNTTK
SLLLAIEEGK IDIEKGRVLD SKSKKTFNFD EAFKRGLLIT LTKPLEEEAV QKVVSDSAVS
PRQLRECALD EAIKFDMLNP DEAVIKDLQT GKFKTVAEAV KDGQLDLAKT VIFDVQAGKV
KSLVVTYDQL LVIYLKEPIG FRQAVDSGLL SITSGKFTVP NTSEELSLKD SIALGFVDPD
SVLLKDSNKK KLIKLPEGFR KGLIDADKGN VLDSATSKLY SLSAALESGL LITPNMGFTL
IETIVYGIYN PTTGCFTDPF VTTSIIDRKK LTLVEAIDEN LVDPSTTVVK DLDGGTIEPL
WQAIESKVVD AVAGRIHDTV EKKEYDFVKA LEKGLILPAE QRQAVQEKYK LCDETLSKLL
HWIGEVEDRI ASQDVIHEVE EELRNQINSI KQIKDDLEQH SGQVSHCGDQ VRQLVLTAGD
ILSKSEVSAL EKSSRNLKTR FDKAVDKTDK LLRRQLAARD ELAKLKSELN LFSTWLGKAR
RILEDKERAL SDLQRLDSSA DSTRDFVSDV IAHQADLRFI TMSAQKFVDE GKEYLNILND
FRTSLPSRLP HIEPLSSQDS PVRSEVSLVT QQYRDLLHRA NNLADRLSGV GGKQREYSDA
LDKARTWLKD AEPRANKLLN EPIGGDPKTV EDQLHKAKAL NNEFVANGKL IDNAKQATSA
LVRSLEGQIS PSEIHRLEEP VESLEGKYNS LSGAIANRCQ ELDTALVQSQ GVQDALDGII
DWLNQAENQF KNMQRPASLI QERLEEQLRE HRGFQSDIDT HISSIDSVYL SANELIVSTS
NARVAKQIEG KLTDVKTRFE KLFDRVQNRG VFLGEVNRDL VAFNNQALKF EKWYSEIMEI
IESRDLAKAP AEQYALQMKE IARNRDDNRA LFEEVVQIGK ELLNKRDVTD TTGVRDRVKN
MESQWRDLEN LMEEKTKLSK LRAEQHSAYE TLKEQVLDWL SRMETKVTRL DLVAIHLETL
RKQHDELKPI SSEYKGYSST IDKVNDIGNA YDSLIRGDRP ESPSRRKGYS PTKRLSGRAS
QDARSPSPTK GLSPLSPGGS SGFSSRRSSQ DGFHLEELSP VQQQLSEINN RYSLLGVKIN
DRQSEIDQLR EELKKQLDNL KTLSAFLEKT QRQLPKDVVP NTKDEADKLN KQIKHVLEEM
YEKQSLLDTT NSQVRDLLKR KAGAMGADNL NDELEEVLSH WKSLSDHLKN RIKFMEDMKE
FHDTHDSLAT WLGAKERMLT VLGPISSDSR MVQSQVQQVQ VLREEFRSQQ PQLQHLVDVG
DDVLSYLEPR SPDHQKINTK LTAIQQRWAD ILGKLEERAE SLGAAADTSR EFDAQLTRLR
DALQGISDNL DEVAFEKNPE DQLRKVEHLE RQLEGQRPLL ADLEANGAQL CEVLSDPASR
ADIQSKLASV GRQYNALQKK LDLKKAEIEG SLRDGRQFEA SCAKTLGWLS DELGSLSERL
LISADRDVLE QQLAHHEPIY RDVLAREHEV IMLLNKGREM VSRSTKTDTR GVQRDLDKIQ
QSWEKLRKEA LDRQTRLKTC QEHCRKYYSV LESFLPWLRQ AEDKIDSLRL QSFEKKHIEK
QLKELQAFRN EVWKKSGEYE NTRSLGDTFL SSCDIDKDIV KNELLELKER WEKLNNDLIL
RTQALEDQSR RLGDFNENLR DLKHGLDRCE DKLASHDALG GASRDPKLLD RIKALREETA
NLKKPLQSLR NQAADLCHEA TENGIDANHL KDEVESIGDR IDDLQSKLND RCSDLQSAAT
AVTQFNEKVK GLSHDLSGLE AELDNMKPPA RDVKAVRGQI DDVVKFIGKV GKASNDVEDA
ILAGERLVDS GFAPDTAQTR QQVDALKRQL GKLDDRAHNR EKELEGALKK LEDFYIGHAG
VLDGIKDAFD QLRKLKPIGS DVEGIRSQQK DFKKFRAATV DPLNKNVETC NRVGQGLVQS
AASGVNTQTL EKDLEKMNDQ WNTLKEKIND RERKLDIALL QSGKFQEALD GLAKWLADTE
ELVANQKPPS ADYKVVKAQL QEQKFLKKML LDRQNSMSSL FSMGNEIAKE ADPSERKAIE
KQLKDLIGRF DALTEGAQQR TLDLEHAMKV AKEFQDKLLP LQDWLERSEK KVKDMSLIPT
DEEKIQQRIR EHDALHNDIL SKKPDFRELA DVASNLMSLV GEDEAAGLAD KLAEVTDRYG
NLVEDSEKIG DLLTASRQGL RHLVLTYQDL AAWMDSMEQR LARYKVLAVH TDRLLEQMDD
LTALTEDIAG RQADVDGTVD AGVELMGHIS SDEALQLKDK LDSLQRRYND LTSRGADLLK
LAQNLLPLVQ KFHNNHNRLV EWMQGAESVL QSAEPNEGDI ARLEVDLQEL RPVLETINVL
GPQLCQASPG EGAATIEGLV SRDNRRFDAI AEQIQRRAER IHLGKQRALE VTGDIDELLE
WFREVESQIR DAEKPSAEPD VIRVQLKEHK ALNDDISSQK GRVRDVLSTA KKVLRESPPS
EDTSLIREKM EDLREAMDTV SALSSDRLGI LEQALPLAEH FHDTHIGLVN WLGDMEEQVS
MLSMPALRPD AIAQQQDRNE LFLQSINEHK PLVDKLNKTG EALIRLCNDD DGSKVQELLD
NDNARYAALK LELRERQQAL EQALQESSLF SDKLEGMLRA LTNTADQVNN QEPISAHVPK
IRDQIEDNDA IVSDLDKRKE AYAAVQRAAD DVINKAGNRA DSAVKDIKRK LDKLKNLWDD
VQKATKDRGH SLDNALDAAQ KFWKELHAIM ATLKDLEDSL VSQEPPAVEP KAIQEQQVAL
QEIRQEIDQT KPEVDQVRSS GQKLMKLCGE PDKPEVKKHI EDLDNAWDNI TALYAKREEN
LIDAMEKAME FHETLQDLLA FLDKAERKFE KMGPLGADID AVKKQIEQLK NFKAEVDPHM
VKVEALNRQA QELTERTSAD QAAAIKEPLS AVNKRWDDLL RGMVDRQRQL ENALLRLGQF
QHALNELLIW ISKTDKTLDE LKPVAGDAQV LEIELAKLKV LINDIQAHQT SVDTLNDAGR
QIIESGEDRY EASTTQEKLN TLNTQWRALV QKAADRQREL EDALTDAHRF NAEIQDLLSW
LGDVDGIIAA SKPVGGLPET ASEQLERFME IYNEIEENRP KVETVLAQGQ EYLKKAPPNS
ASNLQHNLRT LKQRWDSVTA RANDKKIKLE IALKEATEFH ESLQAFVDWL TNAEKILNSL
KPVSRVLDNV QQQIEDHKVF QKDVSAHREI MLALDKKGTH LKYFSQKQDV ILIKNLLISV
QHRWERVAAK SAERTRALDL GYKEAKEFHD SWLGLMHWLD ETEQNLDAFM LDTAGNDPDK
IKARLSKHHE FQRALSAKQS SYDTVMKNGK QLKEKAPKTD EPTLKQMLAD LKGKWTSVCN
KSVESQRKLE EALLYSGQFK DAVAALMAWL KKSEKELSQE SPVHGDLDTV THLFDLHRQF
EKELEKRNDQ MESVMRNGQE LEKTASKTDA AHIRKQMTEL NQLWESVTGL THLKTDRLHD
ALKEAERLHK SVNMILDWLS DAEMKLRFVG NTPEDEATAY EQLKALDEFR AQLSEKEIEK
DQTLNLAHNI LAKAHPDSIN VIKNWIKVIQ SRWEEVSQWA LQRHQKLSLH MQSLRDMDET
LEDLIQWLLG LENTLIALKR EELPMNIPAT EQLIADHKEF MENTQKRQAE VDRVCKAKQV
KAAAGLKDPR KFGKAKAPIR GSQHDIHEHS SDYGTLGRKQ SFKGSRDLLS QRGSRASPGR
ELSPEPGYPH VGPRFSAPGS EPEFRSPRVK FLYDKWRHVW VLSWERQREL YDHLAYLKEK
EKADNFSWDD WRKRFLKFMN YKKSRLTDLF RKMDKDNNEL IPRDDFIDGI IRTSKQRNQL
EPEQFDTSRL EMKHVADMFD ENNRGLIDWK KFIAALRPDW EEKTPDHDAQ KIHDEVKRLV
MLCTCRQKFR VFQVGEGKYR FGDSQKLRLV RILRSTVMVR VGGGWVALDE FLLKNDPCRA
KGRTNIELRE QFILADGVSQ TMTAFKSKRS SASPVSGSSS THEHMAELMP IFNEIRARGE
IGNAYPLHVG STAGPTLHMA HVNPNTCYWV TLICVFLVRE RSQRSVPMGS LPRHSKSTLS
AGTPDSLSDN ESGFRTPRKP VYRSTLTPGG SRNNSRPASR TGSRPGSKPP SRHGSNQSLD
STDDTPSRIP RRTPTSGFSS ATLSSARKST VNGTGSRPRT PSGLRSPASP ALRSASSNKV
RQVTIGVAPT LRTSSRTRTP SGSNTPVYPD QPTAVSRLLR RNSGASETPT GQARRKKSTI
EDREPFRL
//