ID   U4UXQ9_DENPD            Unreviewed;       769 AA.
AC   U4UXQ9;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Cullin family profile domain-containing protein {ECO:0000259|PROSITE:PS50069};
GN   ORFNames=D910_12350 {ECO:0000313|EMBL:ERL95080.1};
OS   Dendroctonus ponderosae (Mountain pine beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Curculionidae; Scolytinae; Dendroctonus.
OX   NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL95080.1, ECO:0000313|Proteomes:UP000030742};
RN   [1] {ECO:0000313|EMBL:ERL95080.1, ECO:0000313|Proteomes:UP000030742}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA   Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA   Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA   Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA   Birol I., Jones S.J., Bohlmann J.;
RT   "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT   a major forest pest.";
RL   Genome Biol. 14:R27-R27(2013).
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   EMBL; KB632404; ERL95080.1; -; Genomic_DNA.
DR   AlphaFoldDB; U4UXQ9; -.
DR   STRING; 77166.U4UXQ9; -.
DR   Proteomes; UP000030742; Unassembled WGS sequence.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF177; CULLIN-2; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          394..643
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   769 AA;  88556 MW;  807E43EE59AAA1B8 CRC64;
     MSLKPRLVDF NSTWGAIKET ITGVITLDHV PRTVWNDRFS DVYSLCVAHP EPLADRLYAE
     TKQYLIDHVA HLLEKVQADG DHCLIKNYFH YWSQYSVGSQ YLHSLYLYLN QQHIKSHKMS
     DAEIIYGNGE SSNSSATADQ MEIGELALQV WQTNMIWPLG HRLVKLLLEA IDLDRAGKPP
     AIHLDAVRGT ILSLVEVQAY RKKSQLQLYA ELFEGPFLDA SGEHFKRDAA LLLQEKNVSL
     YMDKVKGKID EELYRARRFL HASSLSKVTS RCEQHMVAEH LQFLYSECTN MVKYEKKKDL
     ANMYELLKSV TDALVVLVDT VFDHIKNQGL AAIHNLQGDT LHIQFVENLL AVYKKYKELI
     KEVFKSDQNF MGALDKACNS VINHRPNEGR SPCRSPELLA KYCDALLKKS SKGISETEVD
     EKLSESIIIF KYIDDKDIFQ KFYSRSLAKR LIHQQTQSMD AEEAMINRLK QASTATPSRC
     ERFLTDQLLQ ACGYEFTSKL HRMFTDMSVS ADLNNKFQEF TKSEEIELGI NFGIYVLQAG
     AWPLGQAVVT PFALPQQLEK SVQMFETFYH NRFNGRKLTW LHHLCQAELK LGYLKKPYVV
     TVQTFQMAIL LLFEKTDQLS CKEIRETLQL NSEQFKRHAV SLVDSKLLLA NAEEIDETET
     VLRLNMDYLN KRTKFRITAA IQKEAPHEVE QTINSVEEDR KMYLQAAIVR IMKSRKVLKH
     NLLIQEVYAQ SKVSFAPSVP LIKKCIESLI DKQYIERTPH SSEEYSYVA
//