ID   U4UYI4_DENPD            Unreviewed;      1971 AA.
AC   U4UYI4;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=Helicase ATP-binding domain-containing protein {ECO:0000259|PROSITE:PS51192};
GN   ORFNames=D910_12708 {ECO:0000313|EMBL:ERL95446.1};
OS   Dendroctonus ponderosae (Mountain pine beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Curculionidae; Scolytinae; Dendroctonus.
OX   NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL95446.1, ECO:0000313|Proteomes:UP000030742};
RN   [1] {ECO:0000313|EMBL:ERL95446.1, ECO:0000313|Proteomes:UP000030742}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA   Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA   Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA   Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA   Birol I., Jones S.J., Bohlmann J.;
RT   "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT   a major forest pest.";
RL   Genome Biol. 14:R27-R27(2013).
CC   -!- SIMILARITY: Belongs to the Integrator subunit 2 family.
CC       {ECO:0000256|ARBA:ARBA00006705}.
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DR   EMBL; KB632429; ERL95446.1; -; Genomic_DNA.
DR   Proteomes; UP000030742; Unassembled WGS sequence.
DR   GO; GO:0032039; C:integrator complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0016180; P:snRNA processing; IEA:InterPro.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR026236; Int2_metazoa.
DR   InterPro; IPR029321; INTS2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR28608; INTEGRATOR COMPLEX SUBUNIT 2; 1.
DR   PANTHER; PTHR28608:SF1; INTEGRATOR COMPLEX SUBUNIT 2; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF14750; INTS2; 4.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   PRINTS; PR02105; INTSUBUNIT2.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030742}.
FT   DOMAIN          873..1033
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
SQ   SEQUENCE   1971 AA;  224386 MW;  19C4956733B953AD CRC64;
     MGLISALDFS KKCTDMKVNI LTIVSGMELV NSIVALLSID FHKLETDVKK EQQLRLKGNT
     VQNDSLLIGN LSNTSMALEY ERSDMTRRLS ILLGELLYIQ SQIQENTEIV EPESYIKSSD
     LFDNDIFAEE LSDIICIALA ELPTTLTIIS IVETLLHIHN GPEIVCRVVA NFPDSFREVC
     TYLIQTGEKQ EETISSTIRS TTIRLLCRMN PSQALTVRSK CVELCRMPAL AILLSLGELQ
     GDNEGDMVAF VSGLLLGNDQ TIRNWIALFF RTGQKRKGEA SSNALQQLRE ELLKRLQKII
     DLSPEGQIPD TLVVQASALL RLYCALRGIA AIKFQDEEVN LIVQLLTSHP NPTPAGVQWL
     VREEAYFESA SGVTASFGEM LLLMAIHFHS QQLSAICELT CATLGMKIAI RHNNMNRMKQ
     VFTQEIFTEQ VVTAHAVKVP VTRGLSATMT GFLPIHCIHQ LLKSRAFAKH NVNIKNWIYK
     QICTSVSPLH PVLPMLVEVY VNSIMLPNSK TTEHTNKPLT ENEIRRVFQS SVFGQYFDNR
     QSIFTMDFDL NAEDQDVVVD NTSLTPQLLL LYYLLLYEDC LFGPLLKLLA THFPHLTLVE
     DWLDDMSIRV EKKPVHIDEY MVVSAFNEIE TNPYKCAKLL QFMLKVEAID IWPFAESFAQ
     FAKNVLGSNI PRYLQDLYKD VWLRLNTVLP RRLWVLTVKN LVEDFSLVTK IDVAEDPLQI
     MRCDDRVFRC APIYAIVLRV LRASLASSRS QLTQHLQANP RVDAHGQIMN EPDREEICRA
     TIAAQAKPKD PALDRNVLLN ISFAAPTNIL WDKLPVLDKY GEKVELNRQD FEEFLLIIRI
     YKDFQQKSKF SKLHKLRSAQ RDLPIAQYKS EIVNKLKENR VLLIAGNTGC GKSTQVPQYV
     MEAGYTKVVC TQPRRIACIS LAKRVAYETL TDFKSTIGYQ IRFEKSKRAD TSVIFMTEGL
     LLRQASEEET LNSYDVVILD EVHERHLHGD FLIGIMKCVL YKRTNLKLIL MSATINLKLF
     TSYFSEENIE VIQVPGRLYP IEINYKPIVK DPFEKKRDKF NCTPYLQILQ MIDEKYLPNQ
     KGDVLIFLNG FSEISTLADA ITEYRFVIDS GKCNRMIYNT NVGISKLSEA YISQDSAKQR
     SGRAGRTGPG VCYRMYSEED FNSFEGFTPA EIHLVPLDSL ILHMISLGLT DIENFPFLEK
     PSHKAIEESL EKLKFAGALS LSDDCLSLTP LGDSLSQLPV DLSIAKMLIM STIFGNVNSV
     LALASLLSVQ SPLTQTAYRD SEAQNLRRPL ESNHGDPISL LSFFKEWLTI KQSSGPVQGS
     STKSQNSKTW SKKRCLEEQR FYEVTKLLDQ FRDILTEANL LQKIEEHLTS SERSIRYGEL
     KQLKHMKYEL KIESKSRQRK QLKYEMFNYG EDSEKADSKT DLRDVEFRIT NDFKRLQKLL
     NEASADSFKD LMLLKIILTS GFYPQIAVED EHNSSKTVSE RLYHTKNKNY VFLRPMSYFA
     MNPEILELSN DEIEVPPSGY FSKRPISKKH QVLVFQSILE TKKVYLVNAM RMPCIQTLFL
     FGKTISTNSS LTKFVVDDFL ALDVPYLGQA KNLLLKALSL RQKWTQKLEF KLNNPTYKQS
     DADKEDIFYF IEDLVAYMQS AVAYNMKRLL PADLKDLFSY SSETFNHIKD KLKNPFNPGF
     AMCPNTVKGG FNVTENVIYD CLNDEDWAYA VEVNIFETGL LCKHCKETFP GRTLFQFMQH
     EEFCDSKAES AAVQMLLETL VEKEEDVTVP GRRWALQEVR SLVCCYLHQV FIADTTLCKL
     VHFQGYPSEL LEVVVKGVPS MHICLDFLQE LMQQPSLNKQ IFAIQLLSRL SIQYALPKSL
     NLCVTALNLL YALLGGISSS QRVKLFKPVL PALVNISEAF PPLTNDIINL LMQLAKICES
     QASLASHFDS QRGTGLEISA EESAELCDLT KKTFADILDR SVLRGTVYRQ E
//