ID   U4V1A3_9RHOB            Unreviewed;       502 AA.
AC   U4V1A3;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Choline-sulfatase {ECO:0000313|EMBL:ERL98428.1};
GN   ORFNames=HIMB11_01034 {ECO:0000313|EMBL:ERL98428.1};
OS   Rhodobacteraceae bacterium HIMB11.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Paracoccaceae.
OX   NCBI_TaxID=1366046 {ECO:0000313|EMBL:ERL98428.1, ECO:0000313|Proteomes:UP000016848};
RN   [1] {ECO:0000313|EMBL:ERL98428.1, ECO:0000313|Proteomes:UP000016848}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HIMB11 {ECO:0000313|EMBL:ERL98428.1,
RC   ECO:0000313|Proteomes:UP000016848};
RA   Durham B.P., DeLong E.F., Rappe M.S.;
RT   "Draft genome sequence of marine alphaproteobacterial strain HIMB11, the
RT   first cultivated representative of a unique lineage within the Roseobacter
RT   clade possessing a remarkably small genome.";
RL   Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the sulfatase family.
CC       {ECO:0000256|ARBA:ARBA00008779}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ERL98428.1}.
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DR   EMBL; AVDB01000003; ERL98428.1; -; Genomic_DNA.
DR   AlphaFoldDB; U4V1A3; -.
DR   STRING; 1366046.HIMB11_01034; -.
DR   PATRIC; fig|1366046.3.peg.1040; -.
DR   eggNOG; COG3119; Bacteria.
DR   OrthoDB; 9795675at2; -.
DR   Proteomes; UP000016848; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd16032; choline-sulfatase; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR017785; Choline-sulfatase.
DR   InterPro; IPR025863; Choline_sulf_C_dom.
DR   InterPro; IPR024607; Sulfatase_CS.
DR   InterPro; IPR000917; Sulfatase_N.
DR   NCBIfam; TIGR03417; chol_sulfatase; 1.
DR   PANTHER; PTHR45953; IDURONATE 2-SULFATASE; 1.
DR   PANTHER; PTHR45953:SF1; IDURONATE 2-SULFATASE; 1.
DR   Pfam; PF12411; Choline_sulf_C; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR   PROSITE; PS00149; SULFATASE_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016848}.
FT   DOMAIN          4..345
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
FT   DOMAIN          447..498
FT                   /note="Choline sulfatase enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12411"
SQ   SEQUENCE   502 AA;  57478 MW;  C69722FD32984582 CRC64;
     MTTPNILILM VDQLNGTLFP DGPAKWLHAP NLKKLAARSV RFQNCYTASP LCAPGRASFM
     SGQLPSVTGV YDNAAEFPSS LPTYAHHLRR AGYQTALSGK MHFVGPDQLH GFEERLTTDI
     YPPDFGWTPD YRKPGERIDW WYHNMGSVTG AGVAEITNQM EYDDEVAYEA VRKIYDLSRG
     HDPRPWCLTV SFTHPHDPYV ARKKYWDLYE DCDHLLPEIP AMDYNAHDAH SKRIFDANDW
     RNFDITEDDI KRSRRAYFAN ISYLDDKIGE ILETLETTRQ EAVILFVSDH GDMLGERGLW
     FKMSFYEGSS RVPLMMSASG IEPRLVTDPV SNIDVCPTLC DIAGISMQDV APWTQGETLL
     PLSHGGSRTT PVAIEYAAEA SYAPMVSLRS GPYKFNRCAL DPDQLFDLEN DPHELVNLID
     DPEFDDIRAE FSALSDAKWD LARFDDEVRR SQARRWIVYE ALRNGEYYPW DYQPLKKASE
     RFMRNHMDLN VLEKSQRFPR GE
//