ID U5CX18_AMBTC Unreviewed; 321 AA.
AC U5CX18;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase {ECO:0000256|ARBA:ARBA00016378};
DE EC=3.6.1.13 {ECO:0000256|ARBA:ARBA00012453};
DE EC=3.6.1.16 {ECO:0000256|ARBA:ARBA00012443};
DE EC=3.6.1.53 {ECO:0000256|ARBA:ARBA00012529};
DE AltName: Full=ADPRibase-Mn {ECO:0000256|ARBA:ARBA00032579};
DE AltName: Full=CDP-choline phosphohydrolase {ECO:0000256|ARBA:ARBA00030848};
GN ORFNames=AMTR_s00174p00058760 {ECO:0000313|EMBL:ERN14490.1};
OS Amborella trichopoda.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Amborellales; Amborellaceae; Amborella.
OX NCBI_TaxID=13333 {ECO:0000313|EMBL:ERN14490.1, ECO:0000313|Proteomes:UP000017836};
RN [1] {ECO:0000313|Proteomes:UP000017836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24357323;
RG Amborella Genome Project;
RT "The Amborella genome and the evolution of flowering plants.";
RL Science 342:1241089-1241089(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+);
CC Xref=Rhea:RHEA:10412, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57967, ChEBI:CHEBI:78346, ChEBI:CHEBI:456215;
CC EC=3.6.1.13; Evidence={ECO:0000256|ARBA:ARBA00001454};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+);
CC Xref=Rhea:RHEA:10412, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57967, ChEBI:CHEBI:78346, ChEBI:CHEBI:456215;
CC EC=3.6.1.53; Evidence={ECO:0000256|ARBA:ARBA00001583};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CDP-choline + H2O = CMP + 2 H(+) + phosphocholine;
CC Xref=Rhea:RHEA:32487, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:295975;
CC EC=3.6.1.53; Evidence={ECO:0000256|ARBA:ARBA00001789};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CDP-glycerol + H2O = CMP + 2 H(+) + sn-glycerol 3-phosphate;
CC Xref=Rhea:RHEA:21692, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57597, ChEBI:CHEBI:58311, ChEBI:CHEBI:60377; EC=3.6.1.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001209};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the ADPRibase-Mn family.
CC {ECO:0000256|ARBA:ARBA00006362}.
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DR EMBL; KI392534; ERN14490.1; -; Genomic_DNA.
DR RefSeq; XP_011626482.1; XM_011628180.1.
DR AlphaFoldDB; U5CX18; -.
DR STRING; 13333.U5CX18; -.
DR EnsemblPlants; ERN14490; ERN14490; AMTR_s00174p00058760.
DR GeneID; 18442745; -.
DR Gramene; ERN14490; ERN14490; AMTR_s00174p00058760.
DR KEGG; atr:18442745; -.
DR eggNOG; ENOG502QUQW; Eukaryota.
DR HOGENOM; CLU_039893_1_0_1; -.
DR OMA; GHNHAGN; -.
DR OrthoDB; 276166at2759; -.
DR Proteomes; UP000017836; Unassembled WGS sequence.
DR GO; GO:0008663; F:2',3'-cyclic-nucleotide 2'-phosphodiesterase activity; IBA:GO_Central.
DR GO; GO:0047631; F:ADP-ribose diphosphatase activity; IBA:GO_Central.
DR GO; GO:0047734; F:CDP-glycerol diphosphatase activity; IBA:GO_Central.
DR GO; GO:0030145; F:manganese ion binding; IBA:GO_Central.
DR CDD; cd07396; MPP_Nbla03831; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041869; MPP_ADPRM.
DR PANTHER; PTHR16509; -; 1.
DR PANTHER; PTHR16509:SF1; MANGANESE-DEPENDENT ADP-RIBOSE_CDP-ALCOHOL DIPHOSPHATASE; 1.
DR Pfam; PF00149; Metallophos; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000017836};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 20..266
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
SQ SEQUENCE 321 AA; 36357 MW; 152CF62A7D785506 CRC64;
MMALTNGMVD AHVKQPLFSF GVITDVQYAD IPDGRSFRGI PRYYRHSIMV LQKAVKKWNE
HGKLKFSVHF GDIVDGFCPK HESKNAVEKV IEEFQEFKGP VYNMLGNHCL YNLPRDNLIE
LLKIPTLHGH AYYDFTPSPH YRFVVLDGYD ISAIGWPEGH PHQLEAMDLL YKKNPNIDKN
SPMGMVGLER RFLMFNGGVG QGQLEWLDGV LQDATMCEQR VVVCCHLPLD PGAACEEALL
WNYDEVMNII HRFKCVKACI SGHAHEGGYS IDSHGVHHRV LEAALECPPG SDAFGYMDVY
HDRLSLVGTD RMKSTEMAFE S
//
