ID U5D4A7_AMBTC Unreviewed; 575 AA.
AC U5D4A7;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Beta-hexosaminidase {ECO:0000256|PIRNR:PIRNR001093};
DE EC=3.2.1.52 {ECO:0000256|PIRNR:PIRNR001093};
GN ORFNames=AMTR_s00068p00123470 {ECO:0000313|EMBL:ERN20446.1};
OS Amborella trichopoda.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Amborellales; Amborellaceae; Amborella.
OX NCBI_TaxID=13333 {ECO:0000313|EMBL:ERN20446.1, ECO:0000313|Proteomes:UP000017836};
RN [1] {ECO:0000313|Proteomes:UP000017836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24357323;
RG Amborella Genome Project;
RT "The Amborella genome and the evolution of flowering plants.";
RL Science 342:1241089-1241089(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
CC residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00001231,
CC ECO:0000256|PIRNR:PIRNR001093};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285, ECO:0000256|PIRNR:PIRNR001093}.
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DR EMBL; KI392059; ERN20446.1; -; Genomic_DNA.
DR RefSeq; XP_006858979.1; XM_006858917.2.
DR AlphaFoldDB; U5D4A7; -.
DR STRING; 13333.U5D4A7; -.
DR EnsemblPlants; ERN20446; ERN20446; AMTR_s00068p00123470.
DR GeneID; 18448862; -.
DR Gramene; ERN20446; ERN20446; AMTR_s00068p00123470.
DR KEGG; atr:18448862; -.
DR eggNOG; KOG2499; Eukaryota.
DR HOGENOM; CLU_007082_0_2_1; -.
DR OMA; GHDVVMC; -.
DR OrthoDB; 178991at2759; -.
DR Proteomes; UP000017836; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IBA:GO_Central.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0030203; P:glycosaminoglycan metabolic process; IBA:GO_Central.
DR CDD; cd06562; GH20_HexA_HexB-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR029019; HEX_eukaryotic_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF26; BETA-HEXOSAMINIDASE 2; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF14845; Glycohydro_20b2; 1.
DR PIRSF; PIRSF001093; B-hxosamndse_ab_euk; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|PIRNR:PIRNR001093};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR001093};
KW Reference proteome {ECO:0000313|Proteomes:UP000017836};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..575
FT /note="Beta-hexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004658627"
FT DOMAIN 37..154
FT /note="Beta-hexosaminidase eukaryotic type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14845"
FT DOMAIN 174..525
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 337
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
SQ SEQUENCE 575 AA; 63615 MW; E7AB05711EFBA867 CRC64;
MNLHYIPNAL CSLSSLILLL FISSIPTSIA QPPQVLVWPK PRNLTWTPPY SSILLSPTFT
ISYSGSNPYL QNAVSRYLRL ILAEKYTPVR PIPSNLTAST QPLQTLTLSV NDETPPLQHG
VDESYSLSIP NGTAVLWSAT VWGAMRGLET VSQLVWGDPA RLPVGLEIWD SPLFEHRGVM
LDTSRNYYGM REILRTIGAM SENKMNLFHW HITDSHSFPI VLPSVPELAE KGSYGAGMQY
SAEEVRGIVE FGMSRGVRVV PEIDSPGHTG SWAAAYPEIV ACANMFWSPP GKDPLAAEPG
TGHLNPLHPN TYPLLRNVLR DLAALFPDSF LHAGADEVIP GCWKADPKIQ AFLASGGTLS
QLLETHVNAT QPYIESLNRT AIYWEDVLLD STINVKPELL SKETTILQSW NNGPNNTKLI
TSMGYRAIVS SSAFYYLDCG HGDFLGNDSS YDKMGDEGNG GSWCGPFKTW QRIYDYDITY
GLTAEEAKLV LGGEVALWSE QADGTVLDPR LWPRTAAFAE AMWSGNRDET GIKRYAEATD
RLNEWRYRMV ARGVGAEPIQ PLWCLKNPGM CNLSQ
//
