ID U5DNF0_9CHRO Unreviewed; 523 AA.
AC U5DNF0;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=Circadian clock oscillator protein KaiC {ECO:0000256|HAMAP-Rule:MF_01836};
DE EC=2.7.11.1 {ECO:0000256|HAMAP-Rule:MF_01836};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_01836};
GN Name=kaiC {ECO:0000256|HAMAP-Rule:MF_01836};
GN ORFNames=KR51_00022060 {ECO:0000313|EMBL:ERN41230.1};
OS Rubidibacter lacunae KORDI 51-2.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Chroococcales; Aphanothecaceae; Rubidibacter.
OX NCBI_TaxID=582515 {ECO:0000313|EMBL:ERN41230.1, ECO:0000313|Proteomes:UP000016960};
RN [1] {ECO:0000313|EMBL:ERN41230.1, ECO:0000313|Proteomes:UP000016960}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KORDI 51-2 {ECO:0000313|EMBL:ERN41230.1,
RC ECO:0000313|Proteomes:UP000016960};
RA Choi D.H., Noh J.H., Kwon K.-K., Lee J.-H., Ryu J.-Y.;
RT "Draft genome sequence of Rubidibacter lacunae KORDI 51-2.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the KaiC family. {ECO:0000256|HAMAP-
CC Rule:MF_01836}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_01836}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERN41230.1}.
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DR EMBL; ASSJ01000052; ERN41230.1; -; Genomic_DNA.
DR RefSeq; WP_022607309.1; NZ_ASSJ01000052.1.
DR AlphaFoldDB; U5DNF0; -.
DR STRING; 582515.KR51_00022060; -.
DR PATRIC; fig|582515.4.peg.2482; -.
DR eggNOG; COG0467; Bacteria.
DR InParanoid; U5DNF0; -.
DR OrthoDB; 9787927at2; -.
DR Proteomes; UP000016960; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007623; P:circadian rhythm; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0042752; P:regulation of circadian rhythm; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd19485; KaiC-N; 1.
DR CDD; cd19484; KaiC_C; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01836; KaiC; 1.
DR InterPro; IPR013503; Circadian_KaiC_bact.
DR InterPro; IPR030665; KaiC.
DR InterPro; IPR014774; KaiC-like_dom.
DR InterPro; IPR047222; KaiC_C.
DR InterPro; IPR010624; KaiC_dom.
DR InterPro; IPR047221; KaiC_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR02655; circ_KaiC; 1.
DR PANTHER; PTHR42926; -; 1.
DR PANTHER; PTHR42926:SF1; KAIC-LIKE PROTEIN 2; 1.
DR Pfam; PF06745; ATPase; 2.
DR PIRSF; PIRSF039117; KaiC; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51146; KAIC; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_01836};
KW Biological rhythms {ECO:0000256|HAMAP-Rule:MF_01836};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01836};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|HAMAP-Rule:MF_01836};
KW Magnesium {ECO:0000256|HAMAP-Rule:MF_01836};
KW Metal-binding {ECO:0000256|HAMAP-Rule:MF_01836};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01836};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|HAMAP-
KW Rule:MF_01836}; Reference proteome {ECO:0000313|Proteomes:UP000016960};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|HAMAP-Rule:MF_01836};
KW Repressor {ECO:0000256|HAMAP-Rule:MF_01836};
KW Serine/threonine-protein kinase {ECO:0000256|HAMAP-Rule:MF_01836};
KW Transcription {ECO:0000256|HAMAP-Rule:MF_01836};
KW Transcription regulation {ECO:0000256|HAMAP-Rule:MF_01836};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_01836}.
FT DOMAIN 20..261
FT /note="KaiC"
FT /evidence="ECO:0000259|PROSITE:PS51146"
FT DOMAIN 262..494
FT /note="KaiC"
FT /evidence="ECO:0000259|PROSITE:PS51146"
FT BINDING 50
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 51
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 52
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 53
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 54
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 54
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="1"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 55
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 90
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 225
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 226
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 227
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 229
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 231
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 291
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 292
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 293
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 294
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 295
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 296
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 296
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 297
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 319
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 332
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 452
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 458
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 459
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 460
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 462
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 464
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT BINDING 466
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /ligand_note="ligand shared between homodimeric partners"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT MOD_RES 432
FT /note="Phosphoserine; by autocatalysis"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
FT MOD_RES 433
FT /note="Phosphothreonine; by autocatalysis"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01836"
SQ SEQUENCE 523 AA; 58448 MW; 139C25327320C211 CRC64;
MNVSNENGKH HDRNGKVGVQ KIRTMIEGFD EISHGGIPVG RTTLVSGTSG TGKTLLAVQF
LYNGIKNFDE PGIFVTFEES PIDIITNAYS FGWDLQDLTE RGRLFILDAS PDPEGQEIIG
SFDLSALIER IQYAIRKYKA KRVSIDSVTA VFQQYEGASV IRREIFRLSA RLKQIGVSSI
MTTERTEEYG PVARFGVEEF VSDNVVIVRN VLEGERRRRT VEILKLRGTT HMKGEYPFTI
NNNGINIFPL GAMRLTQRSS NIRISSGIKT LDDMCGGGFF QDSIILATGA TGTGKTLLVS
KFLQEGCHGG ERSILFAYEE SRAQLSRNAS SWGIDFEEME KRGLLKLICT YPESAGLEDH
LQSIKSEIQE FKPTRIAIDS LSALARGVTN NAFRQFVIGV TGYAKQEEIT GFFTNTTDQF
LGSHSITDSH ISTITDTIIM LQYVEIRGEM ARAINVFKMR GSWHDKGIRE YVISRQGPDI
KDSFRNYERI ISGAPTRVTA DEKSELSRIA KGVRDITVEE RPE
//
