ID U5E410_NOCAS Unreviewed; 833 AA.
AC U5E410;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=Serine/threonine-protein kinase PknG {ECO:0000256|ARBA:ARBA00014676};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=pknG {ECO:0000313|EMBL:GAD83467.1};
GN ORFNames=NCAST_20_00320 {ECO:0000313|EMBL:GAD83467.1};
OS Nocardia asteroides NBRC 15531.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1110697 {ECO:0000313|EMBL:GAD83467.1, ECO:0000313|Proteomes:UP000017048};
RN [1] {ECO:0000313|EMBL:GAD83467.1, ECO:0000313|Proteomes:UP000017048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 15531 {ECO:0000313|EMBL:GAD83467.1,
RC ECO:0000313|Proteomes:UP000017048};
RX PubMed=24884595; DOI=10.1186/1471-2164-15-323;
RA Komaki H., Ichikawa N., Hosoyama A., Takahashi-Nakaguchi A., Matsuzawa T.,
RA Suzuki K., Fujita N., Gonoi T.;
RT "Genome based analysis of type-I polyketide synthase and nonribosomal
RT peptide synthetase gene clusters in seven strains of five representative
RT Nocardia species.";
RL BMC Genomics 15:323-323(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAD83467.1}.
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DR EMBL; BAFO02000020; GAD83467.1; -; Genomic_DNA.
DR RefSeq; WP_019049697.1; NZ_VBUS01000001.1.
DR AlphaFoldDB; U5E410; -.
DR STRING; 1824.SAMN05444423_101766; -.
DR eggNOG; COG0515; Bacteria.
DR Proteomes; UP000017048; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR031634; PknG_rubred.
DR InterPro; IPR031636; PknG_TPR.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR24363; SERINE/THREONINE PROTEIN KINASE; 1.
DR PANTHER; PTHR24363:SF0; SERINE/THREONINE-PROTEIN KINASE DDB_G0277989-RELATED; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF16919; PknG_rubred; 1.
DR Pfam; PF16918; PknG_TPR; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:GAD83467.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000017048};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527,
KW ECO:0000313|EMBL:GAD83467.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 214..481
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..58
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 89356 MW; AA8B7258CFC11A19 CRC64;
MSTEPPPNGE PAQEDPARQE PTQLTQRPEG QLPGGWTLPP APAEDETMPL PVPPPKQAAH
APTEIAAARP PATQATQRAA VAPATEAAFR VTEPPGTQAT PVESGGATWA SSPQTGPSTA
RSGRSVRTAR SRPTRRLGAG LVPIPTVTPA DPRDAVLADP VVSEGRRFCW RCANPVGRST
PAHAASSAGV CETCGAAYDF RPSLHEGDMV AGQYEIQGCI AHGGLGWIYL AIDRNVSDRW
VVLKGLLHAG DAEAQAVAVA ERQFLAEVAH PSIVKIHNFV EHTAPDGSSI GYIVMEYVGG
HSLRDILEAR PAGERMPLAE AIAYVLEILP ALDHLHSIGL TYNDLKPDNV MVTEDQVKLI
DLGAVATIEA YGNLYGTKGF QAPEIARTGP TPASDVYTVG RTLAALTLHL PSEHGRYLDG
IPDPAAEPLL ARYEFFHRFL LTATDTDPAL RFPSARAMSA QLAGVLREIL AYDTGSEHPQ
LSTVFSPQRT SFGTEELISQ TDAYLDGVGR SPLLDSGDVV AALPIPLIDP ADPSAPLLAA
TANLEPERVL EALHEARERA EADPDNAPET LAGELVFAEA RARLELGESA AVLHLLERVL
GDTDWRADWF TGQAHLLELD FEAAFASFEA VLRVLPGEIA PKLALAATAE LILQHWDTDA
PEQWRSFAER YYDTVWRTDR AVVSAAFGLA RQLAIAGRVG EAVHALDDVP AASRHFTTAQ
TTAILLLLTS TPVADLDEQI LRLAASRAQA IPPGEHRATL MRTLVQGTAL AWLQAGNTPK
RKDAKLFGRP FDERDLRDGT ESGLRALARN APGRAHRYAL VDLANAIRAK SWF
//