ID   U5EN74_NOCAS            Unreviewed;       347 AA.
AC   U5EN74;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   RecName: Full=adenosine deaminase {ECO:0000256|ARBA:ARBA00012784};
DE            EC=3.5.4.4 {ECO:0000256|ARBA:ARBA00012784};
GN   Name=add {ECO:0000313|EMBL:GAD87748.1};
GN   ORFNames=NCAST_37_00550 {ECO:0000313|EMBL:GAD87748.1};
OS   Nocardia asteroides NBRC 15531.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Nocardia.
OX   NCBI_TaxID=1110697 {ECO:0000313|EMBL:GAD87748.1, ECO:0000313|Proteomes:UP000017048};
RN   [1] {ECO:0000313|EMBL:GAD87748.1, ECO:0000313|Proteomes:UP000017048}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 15531 {ECO:0000313|EMBL:GAD87748.1,
RC   ECO:0000313|Proteomes:UP000017048};
RX   PubMed=24884595; DOI=10.1186/1471-2164-15-323;
RA   Komaki H., Ichikawa N., Hosoyama A., Takahashi-Nakaguchi A., Matsuzawa T.,
RA   Suzuki K., Fujita N., Gonoi T.;
RT   "Genome based analysis of type-I polyketide synthase and nonribosomal
RT   peptide synthetase gene clusters in seven strains of five representative
RT   Nocardia species.";
RL   BMC Genomics 15:323-323(2014).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAD87748.1}.
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DR   EMBL; BAFO02000037; GAD87748.1; -; Genomic_DNA.
DR   AlphaFoldDB; U5EN74; -.
DR   STRING; 1824.SAMN05444423_103150; -.
DR   eggNOG; COG1816; Bacteria.
DR   Proteomes; UP000017048; Unassembled WGS sequence.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:UniProt.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11409; ADENOSINE DEAMINASE; 1.
DR   PANTHER; PTHR11409:SF43; ADENOSINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000017048}.
FT   DOMAIN          2..339
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   347 AA;  38165 MW;  DC34CF53BE8DAC75 CRC64;
     MLHDHLDGGL RPATVLELAA DCGYDELPAH DAETLGAWFR DAADSGSLER YLETFAHTVA
     VMQTPEGLRR VARECAIDLA ADGVVYAEVR FAPEQHLEKG LTLDEVVEHT IAGFREGEAV
     AAEQGNPIRV TCLLTAMRHA ARSREIAELT VRFRDRGVGG FDIAGAEAGF PPTRHLDAFE
     YLRANHAHFT IHAGEAFGLP SIHEALAFCG CDRLGHGVRI TDDITVPGDI EDAQLGLVAN
     YVRDMRVPLE LCPSSNVQTG AVPSLDKHPF DLLARLRFRV TVNTDNRLMS DTSMSEEMLK
     LVDTFGYGWS DLERFTINAM KSAFIPFPDR LRIIDEVIKP GYAVLLG
//