ID U5H1E5_USTV1 Unreviewed; 1497 AA.
AC U5H1E5;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Dicer-like protein 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=MVLG_01202 {ECO:0000313|EMBL:KDE08748.1};
OS Microbotryum lychnidis-dioicae (strain p1A1 Lamole / MvSl-1064) (Anther
OS smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Microbotryomycetes; Microbotryales; Microbotryaceae; Microbotryum.
OX NCBI_TaxID=683840 {ECO:0000313|EMBL:KDE08748.1};
RN [1] {ECO:0000313|Proteomes:UP000017200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=p1A1 Lamole {ECO:0000313|Proteomes:UP000017200};
RA Cuomo C., Perlin M., Young S.K., Zeng Q., Gargeya S., Alvarado L.,
RA Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Howarth C., Mehta T.,
RA Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P.,
RA Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Microbotryum violaceum strain p1A1 Lamole.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KDE08748.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=P1A1 Lamole {ECO:0000313|EMBL:KDE08748.1};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Butler R., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heilman E., Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P.,
RA Mehta T., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA White J., Yandava C., Wortman J., Nusbaum C., Birren B.;
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KDE08748.1, ECO:0000313|Proteomes:UP000017200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P1A1 Lamole {ECO:0000313|EMBL:KDE08748.1}, and p1A1 Lamole
RC {ECO:0000313|Proteomes:UP000017200};
RX PubMed=26076695; DOI=10.1186/s12864-015-1660-8;
RA Perlin M.H., Amselem J., Fontanillas E., Toh S.S., Chen Z., Goldberg J.,
RA Duplessis S., Henrissat B., Young S., Zeng Q., Aguileta G., Petit E.,
RA Badouin H., Andrews J., Razeeq D., Gabaldon T., Quesneville H., Giraud T.,
RA Hood M.E., Schultz D.J., Cuomo C.A.;
RT "Sex and parasites: genomic and transcriptomic analysis of Microbotryum
RT lychnidis-dioicae, the biotrophic and plant-castrating anther smut
RT fungus.";
RL BMC Genomics 16:461-461(2015).
RN [4] {ECO:0000313|EnsemblFungi:MVLG_01202T0}
RP IDENTIFICATION.
RG EnsemblFungi;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC {ECO:0000256|PROSITE-ProRule:PRU00657}.
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DR EMBL; AEIJ01000100; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GL541648; KDE08748.1; -; Genomic_DNA.
DR STRING; 683840.U5H1E5; -.
DR EnsemblFungi; MVLG_01202T0; MVLG_01202T0; MVLG_01202.
DR HOGENOM; CLU_000907_4_4_1; -.
DR InParanoid; U5H1E5; -.
DR OMA; YTCANES; -.
DR OrthoDB; 342391at2759; -.
DR Proteomes; UP000017200; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd18034; DEXHc_dicer; 1.
DR CDD; cd00593; RIBOc; 2.
DR Gene3D; 1.20.1320.30; -; 1.
DR Gene3D; 3.30.160.380; Dicer dimerisation domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.1520.10; Ribonuclease III domain; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR038248; Dicer_dimer_sf.
DR InterPro; IPR005034; Dicer_dimerisation_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000999; RNase_III_dom.
DR InterPro; IPR036389; RNase_III_sf.
DR PANTHER; PTHR14950; DICER-RELATED; 1.
DR PANTHER; PTHR14950:SF37; ENDORIBONUCLEASE DICER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF03368; Dicer_dimer; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00636; Ribonuclease_3; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00535; RIBOc; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF69065; RNase III domain-like; 2.
DR PROSITE; PS51327; DICER_DSRBF; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50142; RNASE_3_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000017200};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00657}.
FT DOMAIN 24..206
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 323..491
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 516..616
FT /note="Dicer dsRNA-binding fold"
FT /evidence="ECO:0000259|PROSITE:PS51327"
FT DOMAIN 919..1081
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 1123..1273
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT REGION 1439..1486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1497 AA; 166890 MW; DE9DCD044A8013EF CRC64;
MGDAAVADAA PPGLHVPRLY QEKAMDAAVK RNIICRMDTG TGKTLIAILL TRHITSQPVL
ASEPQVHRLV VFIVPTVSLV DQVAAVLRRQ TTLTVATFIG AMGVEYWKRE QWVANLANAH
VVVMTAQIWL DILTNAYWDL ERVSLIVFDE AHHCSKRHPY AQIMKDHYHP RKVAGDKVPR
ILALTASPIF NAKSPEKSIS ELEANLDARI YEVSSRHADS IQNSASKPKE RLALIAFQPP
SDGITPSETI FLREVEHLTH LELDRRIPAR IDLVRQKFGK AGLAIYLSQL AKDLKLAVSV
QDKLEALVPA SIDVDNLSTH ARALVDVLAK YRDRPEFHGI CFMEARHDTQ ILTQILRRVE
SFDWLRPAFL VGHGDQGKAE NLASSGMKIA EQQRVVAAFR TGEVNLVCAT KVAEEGLDFR
ACNVVIRFDG LQTMTGYIQS RGRAREKNSD FVVLAQPGSI EEEVFLRCQK MEPELRAMYG
SRIELPEIDE DDGPELPDTP VYRVPETGAL LTYGTAIPLL SEYCSLLRAD TYSSWQRPDY
KIEAQERDDF GRTQWKCDLA TPMIHAFGGL RTFHSEPCPS KRVAKQSVAF QACLALHTVG
AIDMWMLPIR ERLGHSGKDA YGRALDDFEK PKPEVRLAFH NLLGVPGRSQ EATETLHVVE
LSPAVGEPYR IGFVTDRCLG SILADAKDLV SPEGDKIVMK VVAAQAIQWN SQDQRQARLS
LLQEVNRQMT RAVINRRIPT DADFELLWAP LEQTSSSIDW DMLDNAFVPV DTNAVEPGSR
IIVLSSGTCH VARLDEVRKD VTTRSDSMAI DGTAQKKRLR LIERYPAWWI FIKVAYRYHG
LEEDTDEQVL TVTSVPVAIP NYLCSPLIKE GEQEEFVPRT TTRNYPVSMC RTCKLDERFW
AFIPMIPSLE RLITDILRIS ITAELFDIPM VDRDLLRQAL TPPSVMAGPN YEILETVGDS
FLKLASTVHI YFQFPGADEG RLSVVRQNSV SNTFLRALNL AKGYSNAILA RKFLTAHWIP
EHAEVPPPEP SAEESTRGVG PKILAEDPRI AAADAVLKKI GRKTLADVIE STLGAAIKTG
GMPLALRVGE QFGLCFGGVT PWHLREGAAR IAAIPATEVP VGLLDLERRL GYKFEQHGRL
LLQAITHRSC RAATTYCYER EEFLGDALLD YWATDRIFKA FENATPRHLT FMRALLVSNP
TLAFLSIRKL DLHKTILHGS ASLELAMLEA QEQAESMTWA MVLTGDMTWL WSPPKVLGDA
FEAILGAIFL DGGCRLEPVF ATLDQIYAEV MPLMRNVETR DPLSRLLIHS QANGCQKTRV
KVTRVPDAVV RTYEATAVIH DVIIATRLNG SQNVARQLAA RDALELLEKE SKEQAAPTKS
FVEAPCTCRE EAEAARLEAE RLKRVEELDE EEHLIDDVAN DGGLADELAA REAQLRTLGA
EEEEEHDEDG EEEQSSKPEV VSKGHAAADA MNVDGTEPIS NGAEDSLARA FKRVRSY
//
