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Database: UniProt
Entry: U5H8M9_USTV1
LinkDB: U5H8M9_USTV1
Original site: U5H8M9_USTV1 
ID   U5H8M9_USTV1            Unreviewed;      1039 AA.
AC   U5H8M9;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   05-JUN-2019, entry version 35.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=MVLG_03582 {ECO:0000313|EMBL:KDE06028.1};
OS   Microbotryum lychnidis-dioicae (strain p1A1 Lamole / MvSl-1064)
OS   (Anther smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC   Microbotryomycetes; Microbotryales; Microbotryaceae; Microbotryum.
OX   NCBI_TaxID=683840 {ECO:0000313|EMBL:KDE06028.1};
RN   [1] {ECO:0000313|EnsemblFungi:MVLG_03582T1, ECO:0000313|Proteomes:UP000017200}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=p1A1 Lamole {ECO:0000313|EnsemblFungi:MVLG_03582T1,
RC   ECO:0000313|Proteomes:UP000017200};
RA   Cuomo C., Perlin M., Young S.K., Zeng Q., Gargeya S., Alvarado L.,
RA   Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., White J., Yandava C.,
RA   Haas B., Nusbaum C., Birren B.;
RT   "The genome sequence of Microbotryum violaceum strain p1A1 Lamole.";
RL   Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KDE06028.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=P1A1 Lamole {ECO:0000313|EMBL:KDE06028.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Butler R., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A.,
RA   Alvarado L., Arachchi H.M., Berlin A., Brown A., Chapman S.B.,
RA   Chen Z., Dunbar C., Freedman E., Gearin G., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heilman E., Heiman D., Howarth C., Larson L.,
RA   Lui A., MacDonald P.J.P., Mehta T., Montmayeur A., Murphy C.,
RA   Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., White J., Yandava C.,
RA   Wortman J., Nusbaum C., Birren B.;
RL   Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:KDE06028.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=P1A1 Lamole {ECO:0000313|EMBL:KDE06028.1};
RX   PubMed=26076695; DOI=10.1186/s12864-015-1660-8;
RA   Perlin M.H., Amselem J., Fontanillas E., Toh S.S., Chen Z.,
RA   Goldberg J., Duplessis S., Henrissat B., Young S., Zeng Q.,
RA   Aguileta G., Petit E., Badouin H., Andrews J., Razeeq D., Gabaldon T.,
RA   Quesneville H., Giraud T., Hood M.E., Schultz D.J., Cuomo C.A.;
RT   "Sex and parasites: genomic and transcriptomic analysis of
RT   Microbotryum lychnidis-dioicae, the biotrophic and plant-castrating
RT   anther smut fungus.";
RL   BMC Genomics 16:461-461(2015).
RN   [4] {ECO:0000313|EnsemblFungi:MVLG_03582T1}
RP   IDENTIFICATION.
RG   EnsemblFungi;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; AEIJ01000347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GL541677; KDE06028.1; -; Genomic_DNA.
DR   EnsemblFungi; MVLG_03582T1; MVLG_03582T1; MVLG_03582.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000017200; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000017200};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017200};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      192    413       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      477    908       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN      945   1018       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     51       Disordered. {ECO:0000256|MobiDB-lite:
FT                                U5H8M9}.
SQ   SEQUENCE   1039 AA;  116549 MW;  19AB0D8F0E73B203 CRC64;
     MSTSPSSSKK PRLDAPPVTS ASNGSLPLVA NPANGFIPDE DVAAPPSTQA GAHAKPLSAL
     FAGAHPARGL SQLKSAVQNG VKGKARNDND DDKVNFESIL KGLNEEVATD SSDQKWNRPA
     LPPIDPDTDA LIFQQIELEE HVVPGTVPQI RAFGVTQAGH SVLLHITGFM PYFWIAAPKG
     FVNDHCVSLM GHLNIVGMNW LELPPGTYQM KRLSEKVSNC QLELEIKHDD LISHAPEGGW
     SHIAPLRVLS FDIECAGRKG IFPEAEIDPV IQIANMVTRQ GETKPFIRNV FTLNTCSHIV
     GTDVIEFEKE ADLLTRWREF VDEVDPDLII GYNISQFDLP YLMDRAKVLK ATKFPYLGRL
     KNVKSDVKDT HFSSKAYGNR DNKETTIDGR LQLDILQVMQ RDYKLRSYTL NSVCAHFLGE
     QKEDVHHSII TDLQNGNAES RRRLAVYCLK DAYLPQRIMD KLMCFINYIE MARVTGIPFN
     YLLSRGQQIK VISQLFRKAQ DTNYLVPAFR SEGSDEQYEG ATVIEPEKGY YDVPIATLDF
     ASLYPSIMQA HNLCYTTLLD AKIAEALNLK EGVDYVRTPN NDLFVKSEKR RGLLPIILED
     LLSARKRARA ELKKETDPFK RAVLDGRQLA LKVSANSVYG FTGATVGKLP CLQISMSVTA
     YGRQMIERTK QEVQDRYNTA NGYEYDATVI YGDTDSVMVR FGCPDLETAM KLGAEAADFV
     TQKFVKPIKL EFEKVYFPYL LISKKRYAGL YWTKPEKYDK MDTKGIETVR RDNCRLVVTV
     IETCLKKMLI DRDVKGAEEY TKQTISDLLQ NKVDLSQLVI TKALAKADYA NKQAHVELAE
     RMRKRDAGSA PALGDRVAYV IIKGTKDARA YEKSEDPLYV LENNIPIDTK YYLDNQLSKP
     LMRIFEPILG EKASSLLTGD HTRIVSIVAP TSGGLMKFAV RTMTCLGCKT PLKPNRPNKA
     VCENCAPRTA ELYAKQLNIT TAHETAYARL WTQCQRCQGS LVQDVLCTSK DCPIFYMRKK
     AQKDVAENVS VLDRFDGTW
//
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