ID U5HH46_USTV1 Unreviewed; 1396 AA.
AC U5HH46;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Flavodoxin-like domain-containing protein {ECO:0000259|PROSITE:PS50902};
GN ORFNames=MVLG_06386 {ECO:0000313|EMBL:KDE03089.1};
OS Microbotryum lychnidis-dioicae (strain p1A1 Lamole / MvSl-1064) (Anther
OS smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Microbotryomycetes; Microbotryales; Microbotryaceae; Microbotryum.
OX NCBI_TaxID=683840 {ECO:0000313|EMBL:KDE03089.1};
RN [1] {ECO:0000313|Proteomes:UP000017200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=p1A1 Lamole {ECO:0000313|Proteomes:UP000017200};
RA Cuomo C., Perlin M., Young S.K., Zeng Q., Gargeya S., Alvarado L.,
RA Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Howarth C., Mehta T.,
RA Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P.,
RA Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Microbotryum violaceum strain p1A1 Lamole.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KDE03089.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=P1A1 Lamole {ECO:0000313|EMBL:KDE03089.1};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Butler R., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heilman E., Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P.,
RA Mehta T., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA White J., Yandava C., Wortman J., Nusbaum C., Birren B.;
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KDE03089.1, ECO:0000313|Proteomes:UP000017200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P1A1 Lamole {ECO:0000313|EMBL:KDE03089.1}, and p1A1 Lamole
RC {ECO:0000313|Proteomes:UP000017200};
RX PubMed=26076695; DOI=10.1186/s12864-015-1660-8;
RA Perlin M.H., Amselem J., Fontanillas E., Toh S.S., Chen Z., Goldberg J.,
RA Duplessis S., Henrissat B., Young S., Zeng Q., Aguileta G., Petit E.,
RA Badouin H., Andrews J., Razeeq D., Gabaldon T., Quesneville H., Giraud T.,
RA Hood M.E., Schultz D.J., Cuomo C.A.;
RT "Sex and parasites: genomic and transcriptomic analysis of Microbotryum
RT lychnidis-dioicae, the biotrophic and plant-castrating anther smut
RT fungus.";
RL BMC Genomics 16:461-461(2015).
RN [4] {ECO:0000313|EnsemblFungi:MVLG_06386T0}
RP IDENTIFICATION.
RG EnsemblFungi;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- COFACTOR:
CC Name=siroheme; Xref=ChEBI:CHEBI:60052;
CC Evidence={ECO:0000256|ARBA:ARBA00001929};
CC -!- SIMILARITY: Belongs to the nitrite and sulfite reductase 4Fe-4S domain
CC family. {ECO:0000256|ARBA:ARBA00010429}.
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DR EMBL; AEIJ01000755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GL541759; KDE03089.1; -; Genomic_DNA.
DR STRING; 683840.U5HH46; -.
DR EnsemblFungi; MVLG_06386T0; MVLG_06386T0; MVLG_06386.
DR HOGENOM; CLU_001975_0_1_1; -.
DR InParanoid; U5HH46; -.
DR OMA; YGSYTQV; -.
DR OrthoDB; 276396at2759; -.
DR Proteomes; UP000017200; Unassembled WGS sequence.
DR GO; GO:0009337; C:sulfite reductase complex (NADPH); IEA:EnsemblFungi.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0004783; F:sulfite reductase (NADPH) activity; IEA:EnsemblFungi.
DR GO; GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0000103; P:sulfate assimilation; IEA:EnsemblFungi.
DR Gene3D; 3.40.50.360; -; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR Gene3D; 3.30.413.10; Sulfite Reductase Hemoprotein, domain 1; 2.
DR HAMAP; MF_01540; CysI; 1.
DR InterPro; IPR011786; CysI.
DR InterPro; IPR001094; Flavdoxin-like.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR005117; NiRdtase/SiRdtase_haem-b_fer.
DR InterPro; IPR036136; Nit/Sulf_reduc_fer-like_dom_sf.
DR InterPro; IPR006067; NO2/SO3_Rdtase_4Fe4S_dom.
DR InterPro; IPR045169; NO2/SO3_Rdtase_4Fe4S_prot.
DR InterPro; IPR045854; NO2/SO3_Rdtase_4Fe4S_sf.
DR InterPro; IPR006066; NO2/SO3_Rdtase_FeS/sirohaem_BS.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR NCBIfam; TIGR02041; CysI; 1.
DR PANTHER; PTHR11493:SF47; SULFITE REDUCTASE [NADPH] SUBUNIT BETA; 1.
DR PANTHER; PTHR11493; SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED; 1.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR Pfam; PF01077; NIR_SIR; 1.
DR Pfam; PF03460; NIR_SIR_ferr; 2.
DR PRINTS; PR00369; FLAVODOXIN.
DR PRINTS; PR00397; SIROHAEM.
DR SUPFAM; SSF52218; Flavoproteins; 1.
DR SUPFAM; SSF56014; Nitrite and sulphite reductase 4Fe-4S domain-like; 2.
DR SUPFAM; SSF55124; Nitrite/Sulfite reductase N-terminal domain-like; 2.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
DR PROSITE; PS00365; NIR_SIR; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Cysteine biosynthesis {ECO:0000256|ARBA:ARBA00023192};
KW Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000017200}.
FT DOMAIN 662..811
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
SQ SEQUENCE 1396 AA; 150415 MW; 2991372995FAB958 CRC64;
MSSSSLHSSV SSTSRIPGAQ LLSSAVLSPA SFASAPTPSP PALVVLSPSE LVQLLPSLKP
LLRSPVVLQV STAASNGDHS AVTALRSTGL PLLYSANQQQ ADANALVAAH VAAQGRAVLH
FGEFAADAIS LGQNASVSQD WVLGAAAAAA SSAQSNGKFA NGSSNGHSHA ASTADALLAS
FESAFGALPS SNAASAVTSS GSGSTVVLAL GDVAALASSL PADVTLVSLN LYRPLSAQRM
RQLVPSGTSN IVVLEQNYQK TAKWSPLFLD VVGAFADSDD EAQVPTILSA TLGQVQDGNV
AFKAIQDAVA IGSSPITIGT VPSPSGSSAF TSATAVPPKH ESTYTNLLNE VFGQRLWVAN
APSSLFPSTS TSTISATSPE YALGHVLGAQ KKREELRRTV REAVAAPGID ESAAKALTAW
LQDDRSDKVV KAASDAAAKV ASSSLRDAQF GRKSNWIIGS EAWSHDLGAS GLHHALSTGA
DVNLLLIDTT SYTLPGEGPT PSQRRKDAGL YAMTYGNAYV ASVAVYGDFS QTLRAFAEAD
AYKGPSIILA YLPGGENDST RALEILKQTK KAIEIGTWPL YRWDPSAEAR GAEVFELDSE
KIKADLRTFL DRQNHLTELS ARLPTFGEAL ESGAGTKLVA LQKRKAREAF DALSNALEGP
PLLVLFASDG GNAEKLAKKF VSRARQRGVA ARALAFDDMP IEDVPFEKNI AFFTSVAGQG
EFPQNGRELW KALQARKVPD LAEVQFSVFG LGDSHYWPRK EDAHYYNKAC KDLHKALLEL
NAQEIVPLGL GDDQDPDGPQ TAYKVWEPAM WKALGVDGFE SNEPELEPIT NEHIKIASNY
LRGTIKEGLE DTTTGALAES DGQLTKFHGI YQQDDRDIRD ERKAAGLEPA YSFMVRMRLP
AGVCTPSQWL AVDEIADRRG NNTFKLTTRQ TFQFHGIVKA NLKPAMQEIN KMLLDTIAAC
GDVNRTVMCS ANPNLGPLHS KVFDFAKELS DGLMPQTSAY AEIWLDKKQI VGEAVKDVEP
LYGEYYLPRK FKIAIAVPPT NDVDVYCHDL GYIAILDANK ELLGFNITIG GGMGVTHSMK
STYPRLADVV GFCTPEQGLE VAKAVLTTQR DNGNRANRKN ARVKYTVDRM GIDAFKAEFE
KRLGYNLQPA RRFEFTSNVD QFGWQTGHDG KKHFTCFVEN GRVQDEPGRP YKTGLAAIAK
AHKGVFRLTA NQHLIISDIP VEEEKTIQSI LSKYNLDKVD FSGLRLSSAA CVAFPTCGLA
MAESERYLPV LIDKVEKVME EEGLRNDSIT MRMTGCPNGC ARPWAAEVAF VGKAPGTYLM
LLGGGYWGQR LNKIYRESVN EEEILAILRP MLKEYALERN DGERFGDFVI RKGYITATES
GKQFYEGMAP GMEVEA
//
