ID U5LDK6_9BACI Unreviewed; 359 AA.
AC U5LDK6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369};
GN ORFNames=N288_20285 {ECO:0000313|EMBL:AGX05929.1};
OS Bacillus infantis NRRL B-14911.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=1367477 {ECO:0000313|EMBL:AGX05929.1, ECO:0000313|Proteomes:UP000017805};
RN [1] {ECO:0000313|EMBL:AGX05929.1, ECO:0000313|Proteomes:UP000017805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-14911 {ECO:0000313|EMBL:AGX05929.1,
RC ECO:0000313|Proteomes:UP000017805};
RA Massilamany C., Smith T.P.L., Loy J.D., Barletta R., Reddy J.;
RT "Complete genome sequence of Bacillus infantis NRRL B-14911 that has
RT potential to induce cardiac disease by antigenic mimicry.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC {ECO:0000256|ARBA:ARBA00005163}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369,
CC ECO:0000256|RuleBase:RU003406}.
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DR EMBL; CP006643; AGX05929.1; -; Genomic_DNA.
DR RefSeq; WP_022544308.1; NC_022524.1.
DR AlphaFoldDB; U5LDK6; -.
DR STRING; 1367477.N288_20285; -.
DR GeneID; 85553750; -.
DR KEGG; bif:N288_20285; -.
DR PATRIC; fig|1367477.3.peg.4062; -.
DR HOGENOM; CLU_025068_2_1_9; -.
DR OrthoDB; 9800864at2; -.
DR UniPathway; UPA00223; -.
DR Proteomes; UP000017805; Chromosome.
DR GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR CDD; cd06109; BsCS-I_like; 1.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR019810; Citrate_synthase_AS.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR11739:SF4; CITRATE SYNTHASE, PEROXISOMAL; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
DR PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000017805};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR001369}.
FT ACT_SITE 250
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 305
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 359 AA; 39244 MW; EA010DB451AFBB23 CRC64;
MIAKGLKGIL AAETSVGHVD GLKGQLIYRG YEIGELTRKC SFEEAAFLLW HGRLPARGEL
DDLKTELHSF RAIPPHVASI ITAMPVSFSM MDVLRTAVSS LGGSLEKPAV RQAVQLTALI
PVMIAFRSRL LEGKQPVDPE PSLGHAANYL YMLKGQIPEK AHSEALETYL LLTMEHGMNA
STFSARVTAS TESDLISAIT SAIGTMKGPL HGGAPSGVIE LLDEIMERGD AEAVIREKLE
RGEKLMGFGH RIYKTLDPRA AALKDKLQQF AGHDTWLDMA LVTEQTALRL LGEYKPGRSL
YTNVEYYAAA IMKALKMDSS LFTPTFTAAR IAGWTAHVIE QADNNAIFRP ESLYIGPLH
//
