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Database: UniProt
Entry: U5LGH8_9BACI
LinkDB: U5LGH8_9BACI
Original site: U5LGH8_9BACI 
ID   U5LGH8_9BACI            Unreviewed;       292 AA.
AC   U5LGH8;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   13-FEB-2019, entry version 26.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   ORFNames=N288_18970 {ECO:0000313|EMBL:AGX05672.1};
OS   Bacillus infantis NRRL B-14911.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=1367477 {ECO:0000313|EMBL:AGX05672.1, ECO:0000313|Proteomes:UP000017805};
RN   [1] {ECO:0000313|EMBL:AGX05672.1, ECO:0000313|Proteomes:UP000017805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL B-14911 {ECO:0000313|EMBL:AGX05672.1,
RC   ECO:0000313|Proteomes:UP000017805};
RA   Massilamany C., Smith T.P.L., Loy J.D., Barletta R., Reddy J.;
RT   "Complete genome sequence of Bacillus infantis NRRL B-14911 that has
RT   potential to induce cardiac disease by antigenic mimicry.";
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
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DR   EMBL; CP006643; AGX05672.1; -; Genomic_DNA.
DR   RefSeq; WP_009796109.1; NC_022524.1.
DR   EnsemblBacteria; AGX05672; AGX05672; N288_18970.
DR   KEGG; bif:N288_18970; -.
DR   PATRIC; fig|1367477.3.peg.3783; -.
DR   KO; K04518; -.
DR   OrthoDB; 1280729at2; -.
DR   BioCyc; BINF1367477:G1HL0-3562-MONOMER; -.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000017805; Chromosome.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Complete proteome {ECO:0000313|Proteomes:UP000017805};
KW   Lyase {ECO:0000256|RuleBase:RU361254};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017805}.
FT   DOMAIN        2    182       Prephenate dehydratase.
FT                                {ECO:0000259|PROSITE:PS51171}.
FT   DOMAIN      199    276       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   SITE        175    175       Essential for prephenate dehydratase
FT                                activity. {ECO:0000256|PIRSR:PIRSR001500-
FT                                2}.
SQ   SEQUENCE   292 AA;  32378 MW;  F1AFA5F1B6D148CC CRC64;
     MKAGYLGPKA TFTDLAVRAM FPETESIPYR TIPGCMDAVL NEEIDFAVVP IENALEGSVN
     ITLDYLVHEV DLPICGEITA PISQHLMVHP EHAEEWQDTE IIYSHSHAIA QCHKFLHQDL
     RGIPSENMTS TAAAAQFVKE NPEMKAAAIA NELAAEEYGL VIVKRNIHDF QYNHTRFAVI
     SKKPVKLDRT KALGFKTTVM ATLPSDRAGA LHQVLSAFAW RKLNLTKIES RPMKTGLGNY
     FFIIDIDMEA DDILIPGAVA ELEALGCGVK ILGSYPYYQI GRKTRDKASN AH
//
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