ID U5MSC7_CLOSA Unreviewed; 724 AA.
AC U5MSC7;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Tetracycline resistance protein TetP {ECO:0000313|EMBL:AGX42551.1};
GN Name=tetP {ECO:0000313|EMBL:AGX42551.1};
GN ORFNames=CLSA_c15510 {ECO:0000313|EMBL:AGX42551.1};
OS Clostridium saccharobutylicum DSM 13864.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1345695 {ECO:0000313|EMBL:AGX42551.1, ECO:0000313|Proteomes:UP000017118};
RN [1] {ECO:0000313|EMBL:AGX42551.1, ECO:0000313|Proteomes:UP000017118}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13864 {ECO:0000313|EMBL:AGX42551.1};
RX PubMed=24285650;
RA Poehlein A., Hartwich K., Krabben P., Ehrenreich A., Liebl W., Durre P.,
RA Gottschalk G., Daniel R.;
RT "Complete Genome Sequence of the Solvent Producer Clostridium
RT saccharobutylicum NCP262 (DSM 13864).";
RL Genome Announc. 1:e00997-13(2013).
CC -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC synthesis by a non-covalent modification of the ribosomes.
CC {ECO:0000256|ARBA:ARBA00003987}.
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DR EMBL; CP006721; AGX42551.1; -; Genomic_DNA.
DR RefSeq; WP_022744890.1; NZ_AYXL01000320.1.
DR AlphaFoldDB; U5MSC7; -.
DR GeneID; 55474050; -.
DR KEGG; csb:CLSA_c15510; -.
DR PATRIC; fig|1345695.10.peg.3660; -.
DR eggNOG; COG0480; Bacteria.
DR HOGENOM; CLU_002794_5_1_9; -.
DR OrthoDB; 9801472at2; -.
DR Proteomes; UP000017118; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR CDD; cd03711; Tet_C; 1.
DR CDD; cd04168; TetM_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR035650; Tet_C.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43261:SF1; RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43261; TRANSLATION ELONGATION FACTOR G-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000017118}.
FT DOMAIN 1..259
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 724 AA; 83002 MW; F4F4FF1AE8E35735 CRC64;
MKKTIGVLAH VDAGKTTFSE QVLYHTNSIR SRGRVDHKDA FLDSHSIERK RGITVFSDQA
VFKFSDSTYY LIDTPGHVDF STEMERSIGI MDYAIIIISA VEGVQGHTKT VWRLLEKYKI
PTFFFINKLD RVGADKDKVI EEIKKNLTKD ICYIDKSSIK FKADKEFNYE SKVNNSNTQN
VQNNYLDLND EIIEFISEYD EVLLEKYLDG EYDEKLWKNV FRNLIKENKV FPCFAGSALQ
DEGILEFIYG LDELTFTNYE DLNIADCNDN SSLMPMFRDN ILNTTNKFAG YVYKVRHEAT
GNRITFIKCL KGELKVRDEI IHGGEIKANN YSNEMEKSDN SKLQLSFEYG NEIKEKVSSI
RIYNGNKFKA VDNVKAGDVF GVTGLTNVLP GEGIGELRLK TNYEMVPTLM SKVIFDAFYN
IKEVLGYFKL LEAEDPALNV IWSEAIQEMH VHIMGKIQLE VLKEIVEERF NLSVEFGPCE
ILYKESILET AIGSGHFEPL RHYAEVHLKI EPLPRNSGII FDNKCHSDHL TIGNQNLIKT
HIFEREHHGI LTGSPLTDIK ITLLTGRAHL KHTSGGDFRE ATFRALRQGL EKVENILLEP
YYKFTIEVEQ DFIGRVLSDI QKMDGTFDAP EIAKDKMIVN GRGPVARFMD YPMEVIAFTK
GKGHINLIYD GYDNCHNSEE VIQKRDYNKN ADIEYTSSSI FCSHGQGYIV EWDEADKSMH
CELE
//
