ID   U5N9Y5_9BURK            Unreviewed;       649 AA.
AC   U5N9Y5;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   SubName: Full=Heterodisulfide reductase subunit A {ECO:0000313|EMBL:AGX88217.1};
GN   Name=hdrA {ECO:0000313|EMBL:AGX88217.1};
GN   ORFNames=Cenrod_2147 {ECO:0000313|EMBL:AGX88217.1};
OS   Candidatus Symbiobacter mobilis CR.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae.
OX   NCBI_TaxID=946483 {ECO:0000313|EMBL:AGX88217.1, ECO:0000313|Proteomes:UP000017184};
RN   [1] {ECO:0000313|EMBL:AGX88217.1, ECO:0000313|Proteomes:UP000017184}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CR {ECO:0000313|EMBL:AGX88217.1};
RX   PubMed=24267588; DOI=10.1186/gb-2013-14-11-r127;
RA   Liu Z., Muller J., Li T., Alvey R.M., Vogl K., Frigaard N.U.,
RA   Rockwell N.C., Boyd E.S., Tomsho L.P., Schuster S.C., Henke P., Rohde M.,
RA   Overmann J., Bryant D.A.;
RT   "Genomic analysis reveals key aspects of prokaryotic symbiosis in the
RT   phototrophic consortium "Chlorochromatium aggregatum".";
RL   Genome Biol. 14:R127-R127(2013).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- SIMILARITY: Belongs to the HdrA family.
CC       {ECO:0000256|ARBA:ARBA00006561}.
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DR   EMBL; CP004885; AGX88217.1; -; Genomic_DNA.
DR   RefSeq; WP_022775388.1; NC_022576.1.
DR   AlphaFoldDB; U5N9Y5; -.
DR   STRING; 946483.Cenrod_2147; -.
DR   KEGG; cbx:Cenrod_2147; -.
DR   PATRIC; fig|946483.4.peg.2162; -.
DR   eggNOG; COG1148; Bacteria.
DR   HOGENOM; CLU_020302_0_0_4; -.
DR   OrthoDB; 9816402at2; -.
DR   Proteomes; UP000017184; Chromosome.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.20; -; 2.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR039650; HdrA-like.
DR   PANTHER; PTHR43498:SF1; COB--COM HETERODISULFIDE REDUCTASE IRON-SULFUR SUBUNIT A; 1.
DR   PANTHER; PTHR43498; FERREDOXIN:COB-COM HETERODISULFIDE REDUCTASE SUBUNIT A; 1.
DR   Pfam; PF12831; FAD_oxidored; 1.
DR   Pfam; PF00037; Fer4; 1.
DR   Pfam; PF12838; Fer4_7; 1.
DR   PRINTS; PR00419; ADXRDTASE.
DR   SUPFAM; SSF54862; 4Fe-4S ferredoxins; 2.
DR   SUPFAM; SSF51971; Nucleotide-binding domain; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 3.
DR   PROSITE; PS51379; 4FE4S_FER_2; 3.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017184}.
FT   DOMAIN          240..269
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
FT   DOMAIN          575..604
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
FT   DOMAIN          606..635
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
SQ   SEQUENCE   649 AA;  69050 MW;  362CBE93BAA3AE47 CRC64;
     MNQPSRTAVI LCTCSGIITE RIDWDRVQQL LACHPTRPLF RIDDLACAAD HLEATAQWLR
     EEQPDRLVVA ACSPREHEST FRKLMADAGL NPYFMQLVNV REQIAWVTAD PVQATAKAAR
     MLSAALYRVQ RHVPLQERSF PVRSDVAVIG AGPAGIQAAL TLARAGRKVT LIEKEPFIGG
     LPVRFEELFP NLDCGPCLLE PVMGEVLHGP ESESIQVLTL SEVTAVKGGF GNWNLTVRQS
     PRYIDPELCI GCMECVAVCP ARRPNVWNGL SDMAAVGAPF AGALPNLPHI DPAACLRLND
     SGGQDCDACV GQCPVEGALR FDDAPTTHSI DVGAIILATG CVEEDSLPGV FAGLADIHTA
     YAFERLLAMN GPTEGELRTA RGGPPKSLAI VHCAGSLDED GVPYCSGTCC RDALKFAHLA
     AHKVEGLSVT RLVREQMAPG VDAAHLFHHD QSRVVRYGGM DRLHVAGKGA DRVIVCTDTN
     ERVAAEMIVL MRPLVPGQGT ASVCEVLELD RDGAGFIATA HSLAGSCSTA LKGVYLAGSC
     RGPGDIREAF ATGTAAAGLV LSDLVAQRDI VVDPQVAVVD VDRCSGCVTC LPLCPYKAIS
     WNDADRVAHI EDTLCQGCGT CVAACPAGAI EGRGFSRDML RAELEGILS
//