ID U5NBM2_9MOLU Unreviewed; 844 AA.
AC U5NBM2;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=PRV_00160 {ECO:0000313|EMBL:AGX88817.1};
OS Mycoplasma parvum str. Indiana.
OC Bacteria; Mycoplasmatota; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=1403316 {ECO:0000313|EMBL:AGX88817.1, ECO:0000313|Proteomes:UP000017119};
RN [1] {ECO:0000313|EMBL:AGX88817.1, ECO:0000313|Proteomes:UP000017119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indiana {ECO:0000313|EMBL:AGX88817.1,
RC ECO:0000313|Proteomes:UP000017119};
RX PubMed=24285648;
RA do Nascimento N.C., Dos Santos A.P., Chu Y., Guimaraes A.M., Pagliaro A.,
RA Messick J.B.;
RT "Genome Sequence of Mycoplasma parvum (Formerly Eperythrozoon parvum), a
RT Diminutive Hemoplasma of the Pig.";
RL Genome Announc. 1:e00986-13(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
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DR EMBL; CP006771; AGX88817.1; -; Genomic_DNA.
DR RefSeq; WP_022768739.1; NC_022575.1.
DR AlphaFoldDB; U5NBM2; -.
DR STRING; 1403316.PRV_00160; -.
DR KEGG; mpv:PRV_00160; -.
DR PATRIC; fig|1403316.3.peg.24; -.
DR HOGENOM; CLU_002977_6_1_14; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000017119; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 3.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000017119};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 24..491
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT COILED 456..501
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 844 AA; 96319 MW; 112450E205B3DEC1 CRC64;
MNDTSPSKIS KILEIIASSK VEEGNITTTC DQSFLNYSLS VITSRALPDL RDGLKPVHRR
ILYAAYEERL FNEGRFKKSA TLVGAVMGSY HPHGDKSIYD ALVRLSQDFK MRYPLLEGQG
NFGSIDGDAP AAMRYTEVKM SKLGQKFLEG IKEECVEFLD NYDGSKKEPS VLPIIAPSIL
LNGSEGIAVG MATKIPSHNL KEVCEAAIAL IDNPQLEDER LIDYIKGPDF ATGCEILGTE
GIKKYLKEGI GKIWLRAKVE LNKEKNQLII REIPFGIVKS KLIKKIATLS TIEKKSKERK
NAVLQRFILN IRDESNLKEG IRLIIQCREG SDLNAVLNNL YKYTALQTQY TFNLTLLNKG
KPERMGVGGI LRNYLIYQVE VLKRKTNFNL RKLEERIHLL EGRWVVVNDL QEVIRIITEE
ESPEEKIKSY FNDSKRENRI LLSEKQIDDI FSLPLRQLKK IERKKLKDEL DEKKESKEEC
LKMLSNEKEQ FLKIKKDLKQ LIGEFDKDRR KTQINDEQCY KIGKTELIPE ENLIIKCTSD
NYIGAVLLNE YRVYKGVSKG EESEHSEDRK WGVNSAVLVA SSKESLYMFT NYGRVYKIEA
HLVKVGEKKR WPKNPEKLDK RVNLKKGEKV VKIITFGGDV DTKNRNLFLV SKRGYIKRLK
LENLRCIRKN GKLVKRMKEG DELGDVTIGR EDGIIIIVTR KGKMIKFDTK KVKLRGRLSG
GIRGIRLNQS VTDEVVGVNV GSSYGWDVIV TKSGQIKKVK STLIKTKNRG GKGICVSRVG
EEIAAALWVD EEDWTKFIVG TKNGKIVSVE WSNIPERKQR VSRGKDVIKL DKRKRDSIDF
CIKT
//
