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Database: UniProt
Entry: U5Q8M6_9BACT
LinkDB: U5Q8M6_9BACT
Original site: U5Q8M6_9BACT 
ID   U5Q8M6_9BACT            Unreviewed;       275 AA.
AC   U5Q8M6;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   08-MAY-2019, entry version 25.
DE   RecName: Full=2-dehydro-3-deoxyphosphooctonate aldolase {ECO:0000256|SAAS:SAAS00700405};
DE            EC=2.5.1.55 {ECO:0000256|SAAS:SAAS00700404};
GN   Name=kdsA {ECO:0000313|EMBL:AGY53654.1};
GN   ORFNames=BRDCF_p1027 {ECO:0000313|EMBL:AGY53654.1};
OS   Bacteroidales bacterium CF.
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales.
OX   NCBI_TaxID=1400053 {ECO:0000313|EMBL:AGY53654.1, ECO:0000313|Proteomes:UP000017642};
RN   [1] {ECO:0000313|EMBL:AGY53654.1, ECO:0000313|Proteomes:UP000017642}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CF {ECO:0000313|EMBL:AGY53654.1};
RX   PubMed=24356833;
RA   Tang S., Edwards E.A.;
RT   "Complete Genome Sequence of Bacteroidales Strain CF from a
RT   Chloroform-Dechlorinating Enrichment Culture.";
RL   Genome Announc. 1:e01066-13(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-
CC         deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate;
CC         Xref=Rhea:RHEA:14053, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57693, ChEBI:CHEBI:58702, ChEBI:CHEBI:85985;
CC         EC=2.5.1.55; Evidence={ECO:0000256|SAAS:SAAS01123735};
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC       biosynthesis. {ECO:0000256|SAAS:SAAS00700395}.
CC   -!- PATHWAY: Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate
CC       biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-
CC       phosphate: step 2/3. {ECO:0000256|SAAS:SAAS00700401}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00700398}.
CC   -!- SIMILARITY: Belongs to the KdsA family.
CC       {ECO:0000256|SAAS:SAAS00700400}.
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DR   EMBL; CP006772; AGY53654.1; -; Genomic_DNA.
DR   RefSeq; WP_022545726.1; NZ_CP006772.1.
DR   KEGG; bacc:BRDCF_p1027; -.
DR   KO; K01627; -.
DR   OrthoDB; 687380at2; -.
DR   UniPathway; UPA00030; -.
DR   UniPathway; UPA00357; UER00474.
DR   Proteomes; UP000017642; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008676; F:3-deoxy-8-phosphooctulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006269; KDO8P_synthase.
DR   PANTHER; PTHR21057; PTHR21057; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   TIGRFAMs; TIGR01362; KDO8P_synth; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000017642};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00700397};
KW   Lipopolysaccharide biosynthesis {ECO:0000256|SAAS:SAAS00700406};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017642};
KW   Transferase {ECO:0000256|SAAS:SAAS00080156,
KW   ECO:0000313|EMBL:AGY53654.1}.
FT   DOMAIN       13    260       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   275 AA;  30117 MW;  C29A31CC7A32B493 CRC64;
     MIVDQIEYIK HYPDNNFFLI AGPCVIESEE LTRSVAEKTI EITTKLSIPF IFKSSYRKAN
     RSKADSFTGM GDEKGLAILQ KIKEDFKVPV LTDIHNPSEA ALAASYKVDV LQIPAFLCRQ
     TDLLEAAALT GKVINIKKGQ FLAPISMKFA AEKVAQAGNN KIMLTDRGTQ FGYSDLIVDF
     RSIPEMSSFG YPVILDVTHS LQQPNQASGV TGGRPDLIST MARAGIAAGV DGIFIETHPE
     PSKALSDGAN MLKLELLEKT LTSLIPFRKA YNSIK
//
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