ID U5Q8R0_9BACT Unreviewed; 459 AA.
AC U5Q8R0;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Tryptophanase {ECO:0000313|EMBL:AGY54843.1};
DE EC=4.1.99.1 {ECO:0000313|EMBL:AGY54843.1};
GN Name=tnaA {ECO:0000313|EMBL:AGY54843.1};
GN ORFNames=BRDCF_p2216 {ECO:0000313|EMBL:AGY54843.1};
OS Bacteroidales bacterium CF.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales.
OX NCBI_TaxID=1400053 {ECO:0000313|EMBL:AGY54843.1, ECO:0000313|Proteomes:UP000017642};
RN [1] {ECO:0000313|EMBL:AGY54843.1, ECO:0000313|Proteomes:UP000017642}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CF {ECO:0000313|EMBL:AGY54843.1};
RX PubMed=24356833;
RA Tang S., Edwards E.A.;
RT "Complete Genome Sequence of Bacteroidales Strain CF from a Chloroform-
RT Dechlorinating Enrichment Culture.";
RL Genome Announc. 1:e01066-13(2013).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR611166-50};
CC -!- SIMILARITY: Belongs to the beta-eliminating lyase family.
CC {ECO:0000256|ARBA:ARBA00009721}.
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DR EMBL; CP006772; AGY54843.1; -; Genomic_DNA.
DR AlphaFoldDB; U5Q8R0; -.
DR STRING; 1400053.BRDCF_p2216; -.
DR KEGG; bacc:BRDCF_p2216; -.
DR HOGENOM; CLU_047223_0_0_10; -.
DR OrthoDB; 9764079at2; -.
DR Proteomes; UP000017642; Chromosome.
DR GO; GO:0009034; F:tryptophanase activity; IEA:UniProtKB-EC.
DR CDD; cd00617; Tnase_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR001597; ArAA_b-elim_lyase/Thr_aldolase.
DR InterPro; IPR011166; Beta-eliminating_lyase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR32325; BETA-ELIMINATING LYASE-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR32325:SF4; TRYPTOPHANASE; 1.
DR Pfam; PF01212; Beta_elim_lyase; 1.
DR PIRSF; PIRSF001386; Trpase; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:AGY54843.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR611166-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000017642}.
FT DOMAIN 47..423
FT /note="Aromatic amino acid beta-eliminating lyase/threonine
FT aldolase"
FT /evidence="ECO:0000259|Pfam:PF01212"
FT MOD_RES 258
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR611166-50"
SQ SEQUENCE 459 AA; 52203 MW; 44A928E80B0B6411 CRC64;
MELPFAESYK IKMVESIRKS TREERLKWMS DAKYNLFNLK SDFVFIDLLT DSGTGAMSDK
QWAAMMEGDE SYAGARSYYK LKEAIFDVTG FPYFLPTHQG RAAENVLFSS LVKADDVLPG
NSHFDTTKGH IEFRKAHAID CTIEAAADTT LELPFKGNMD LNKLENVLKK YPAERIPCIV
LTITNNTAGG QPVSMENIKG VSALAKKYGV KLLIDSARFA ENAYFIKTRE KGYENKSIRE
ITREIFSHAD FMTMSSKKDA IVNMGGFIGF RNEQDWQKCQ MYNIMFEGFI TYGGMSGRDM
NALAVGLFEG TEFDYLETRI SQVAYLGKKL DEYGIPYQRP SGGHAIFLDA KKILTHVPKE
QLIAQTLGIE LYLEAGIRGV EIGTLLADRD PETRENRYPE LELLRLAIPR RVYTNNHMDY
IAAAVRNVYE RREKITKGYA ITKELPIMRH FTIELEPVK
//
