ID U5RQQ0_9CLOT Unreviewed; 733 AA.
AC U5RQQ0;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=CAETHG_0838 {ECO:0000313|EMBL:AGY75065.1};
OS Clostridium autoethanogenum DSM 10061.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1341692 {ECO:0000313|EMBL:AGY75065.1, ECO:0000313|Proteomes:UP000017590};
RN [1] {ECO:0000313|EMBL:AGY75065.1, ECO:0000313|Proteomes:UP000017590}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10061 {ECO:0000313|EMBL:AGY75065.1};
RX PubMed=24655715; DOI=10.1186/1754-6834-7-40;
RA Brown S.D., Nagaraju S., Utturkar S., De Tissera S., Segovia S.,
RA Mitchell W., Land M.L., Dassanayake A., Kopke M.;
RT "Comparison of single-molecule sequencing and hybrid approaches for
RT finishing the genome of Clostridium autoethanogenum and analysis of CRISPR
RT systems in industrial relevant Clostridia.";
RL Biotechnol. Biofuels 7:40-40(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP006763; AGY75065.1; -; Genomic_DNA.
DR RefSeq; WP_013239481.1; NZ_CP012395.1.
DR AlphaFoldDB; U5RQQ0; -.
DR KEGG; cah:CAETHG_0838; -.
DR PATRIC; fig|1341692.11.peg.825; -.
DR HOGENOM; CLU_362043_0_0_9; -.
DR Proteomes; UP000017590; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 1..319
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 22..29
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 733 AA; 85425 MW; EF1493659FEE1154 CRC64;
MKFRDDQLPI MQYKGGTMAV SAVPGAGKTF ITAQLVCKII EEKLNKPGKV LVVTYMNSAV
NNFKNRISHM LEERGIDSNS DYEVMTIHGL AMKVLQERPD AAGLDENFKV IDDLQKIFYL
DNAVKIWRKL GGEKIYRSLL SEYGTKKYDE KSERWWKDFL QISDVLISEL KLNGITPEKV
EENRELLGNN SIIYILNYIY FRYEKMLNLN GYVDYNDILV LAYKALISDE DLRKKFQQKY
SFVFEDECQD SNLVQCDILS IISERVGADN KKRECNLVRV GDLNQSIMGS FTSSNPIYFK
QFLREADKNY VMNRAGRSTR NIMNLANSLV EYTVKNHPEK RCREALRYQK IHPIEDVEDL
KNPEVDEYGI YAYSMSSWED VKKRTIEVVK SFKSKHSDMT LAILIPFNSH VKEIAEELRK
NKIECDELSS TSSERLKIIN ILGKILGFLG EPDSPVKFRD LMYEIIEGDN EKKNVIINNI
TSFKIEDIIK ESVFKTTSVC KLEEIDKNIF EDFICKLRMV KDILANLNMP LQELILYIGY
ELKLNNEDKA ILQYVASYVR HKNAENNSMT LDEISQELLD VRSSAFTHIC NVIYDIRGYE
PVPEKVTVTT YHKSKGLEWD CVFLLYLNNY IYPYSIKGKF RSEHYYFKDE FKNPTAIGKA
EVQKLLQNDV CYNPIIKARE EVICEKIRLL YVAITRAKKY LILMAHYDEN KKDCPSKYFE
IIKKFICENK QSS
//