ID U5RXU4_9CLOT Unreviewed; 813 AA.
AC U5RXU4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=ATP-dependent Clp protease ATP-binding subunit {ECO:0000313|EMBL:AGY76193.1};
GN ORFNames=CAETHG_1974 {ECO:0000313|EMBL:AGY76193.1};
OS Clostridium autoethanogenum DSM 10061.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1341692 {ECO:0000313|EMBL:AGY76193.1, ECO:0000313|Proteomes:UP000017590};
RN [1] {ECO:0000313|EMBL:AGY76193.1, ECO:0000313|Proteomes:UP000017590}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10061 {ECO:0000313|EMBL:AGY76193.1};
RX PubMed=24655715; DOI=10.1186/1754-6834-7-40;
RA Brown S.D., Nagaraju S., Utturkar S., De Tissera S., Segovia S.,
RA Mitchell W., Land M.L., Dassanayake A., Kopke M.;
RT "Comparison of single-molecule sequencing and hybrid approaches for
RT finishing the genome of Clostridium autoethanogenum and analysis of CRISPR
RT systems in industrial relevant Clostridia.";
RL Biotechnol. Biofuels 7:40-40(2014).
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|RuleBase:RU004432}.
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DR EMBL; CP006763; AGY76193.1; -; Genomic_DNA.
DR RefSeq; WP_013240717.1; NZ_CP012395.1.
DR AlphaFoldDB; U5RXU4; -.
DR KEGG; cah:CAETHG_1974; -.
DR PATRIC; fig|1341692.11.peg.1996; -.
DR HOGENOM; CLU_005070_4_1_9; -.
DR Proteomes; UP000017590; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF193; CHAPERONE PROTEIN CLPB; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
DR PROSITE; PS50151; UVR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000313|EMBL:AGY76193.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:AGY76193.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251}.
FT DOMAIN 3..146
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
FT DOMAIN 420..455
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT REGION 143..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 416..462
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 143..162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 813 AA; 91699 MW; 8462E51783FADDED CRC64;
MMFGRFTERA QKVLVYAQEE AQALQHGYVG TEHILLGILK EEGISRNLLS DMNVNIETVR
NFIEEYEGRG EINLYNKEIP LTPRTKRLLE LSLFEARNLN HNYISPEHIL LALIREAEGV
AFTILNNLGV DFNKLRKELV DSLSGEQSSM NSNSTKKENG EPTPTLDQFG RDLTDMAKEG
KLDPVIGRDK ETQRVLEILS RRTKNNPCLI GDPGVGKTAI AEGLAEKIVS CNIPELLRGK
RVVTLDLSSM IAGSKYRGEF EERLKKVMEE IRKSGNVILF IDEIHTIIGA GAAEGAIDAS
NILKPALARG EIQCIGATTI DEYRKYIEKD AALERRFQPI IVGEPTKEEA VLILKGLRDK
YEAHHRVKII DEAIDAAVNL SDRYITDRYL PDKAIDLIDE AAAKVRIQNL IAPPDLKNLE
EELEKATKEK EDSIRVQDFE KAASLRDKEK ELKNKLEGLK TNWKTKKEVS TLTVGEDQIA
SVVSQWTNIP VEKLTEKESE RLLKLEEILH KRVVGQDEAV KSISKAVRRA RVGLKDPKRP
IGSFIFLGPT GVGKTELSKA LAEAMFGDEN NMIRIDMSEY MEKHTVSRLI GSPPGYVGYD
EGGQLTEKVR RNPYSVVLFD EIEKAHPEVF NILLQILEDG RLTDGKGKTI NFKNTIIIMT
SNVGAATIRK QKSMGFTAAK GDDKESQYEK MKDNIMEELK NSFRPEFLNR IDDIIVFHQL
EEEDLKQIVK LMLKDVSSRL KDQEIEIGFT DKAQELLAKE GFDLTYGARP LRRAITKTVE
DKLSEEMLRG NVKKGDKVKV VVEKGELSFN KVN
//
