ID U5SBK6_9LACT Unreviewed; 383 AA.
AC U5SBK6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Hydroxyacid dehydrogenase {ECO:0000313|EMBL:AGY82605.1};
GN ORFNames=Q783_10610 {ECO:0000313|EMBL:AGY82605.1};
OS Carnobacterium inhibens subsp. gilichinskyi.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae;
OC Carnobacterium.
OX NCBI_TaxID=1266845 {ECO:0000313|EMBL:AGY82605.1, ECO:0000313|Proteomes:UP000017469};
RN [1] {ECO:0000313|EMBL:AGY82605.1, ECO:0000313|Proteomes:UP000017469}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WN1359 {ECO:0000313|EMBL:AGY82605.1,
RC ECO:0000313|Proteomes:UP000017469};
RX PubMed=24285647;
RA Leonard M.T., Panayotova N., Farmerie W.G., Triplett E.W., Nicholson W.L.;
RT "Complete Genome Sequence of Carnobacterium gilichinskyi Strain WN1359T
RT (DSM 27470T).";
RL Genome Announc. 1:e00985-13(2013).
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR EMBL; CP006812; AGY82605.1; -; Genomic_DNA.
DR RefSeq; WP_023179456.1; NC_022606.1.
DR AlphaFoldDB; U5SBK6; -.
DR STRING; 1266845.Q783_10610; -.
DR KEGG; caw:Q783_10610; -.
DR PATRIC; fig|1266845.5.peg.2019; -.
DR eggNOG; COG0111; Bacteria.
DR HOGENOM; CLU_019796_9_0_9; -.
DR Proteomes; UP000017469; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43761:SF1; 2-HACID_DH DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR43761; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630); 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719}.
FT DOMAIN 29..296
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 99..264
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 383 AA; 42548 MW; D876E9D606A3EFE6 CRC64;
MYKLRLIDSI PDGLIARLQQ PNFEISQEKE TEGILVRSSN VPDEAITEEL LVISRSGVGV
NTINLEAATE NGTAVLNTPG VNANAVKELV LACLFLTVRP VATAAEMVRT LKGPDILGQA
ESKRSDYVGQ ELQGKTIGLL GMGAIGTQIA RSCYDLGMEV LGYARREHDI DYVNQVDLDE
LLHLSDFVVV VLPLTNETRD LLTEEKLGQM KKGAYLLNFG RDPIVNSTGI LKVLQDEIIA
GYITDFPQEE YIGHPNILML PHIGGTTQEA LKGGDRLAVR ALRNFLLFGT VRESVNFPAT
RLVFQSPYRL TIFYQKTGKT WSKIMNYLDQ ENLKIGNMTS NGKDGYDYML IDLEESFDRI
EPVAKKIQDI SSVKRVRILS KPN
//
