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Database: UniProt
Entry: U5T8E3_9GAMM
LinkDB: U5T8E3_9GAMM
Original site: U5T8E3_9GAMM 
ID   U5T8E3_9GAMM            Unreviewed;       357 AA.
AC   U5T8E3;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   11-DEC-2019, entry version 32.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=SPICUR_07900 {ECO:0000313|EMBL:AGY92537.1};
OS   Spiribacter curvatus.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae; Spiribacter.
OX   NCBI_TaxID=1335757 {ECO:0000313|EMBL:AGY92537.1, ECO:0000313|Proteomes:UP000017640};
RN   [1] {ECO:0000313|EMBL:AGY92537.1, ECO:0000313|Proteomes:UP000017640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAH-SP71 {ECO:0000313|EMBL:AGY92537.1,
RC   ECO:0000313|Proteomes:UP000017640};
RX   PubMed=24225341; DOI=10.1186/1471-2164-14-787;
RA   Lopez-Perez M., Ghai R., Leon M.J., Rodriguez-Olmos A., Copa-Patino J.L.,
RA   Soliveri J., Sanchez-Porro C., Ventosa A., Rodriguez-Valera F.;
RT   "Genomes of "Spiribacter", a streamlined, successful halophilic
RT   bacterium.";
RL   BMC Genomics 14:787-787(2013).
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP) and
CC       D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-
CC       heptulosonate-7-phosphate (DAHP). {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702; EC=2.5.1.54;
CC         Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; CP005990; AGY92537.1; -; Genomic_DNA.
DR   RefSeq; WP_023367792.1; NC_022664.1.
DR   STRING; 1335757.SPICUR_07900; -.
DR   EnsemblBacteria; AGY92537; AGY92537; SPICUR_07900.
DR   KEGG; spiu:SPICUR_07900; -.
DR   PATRIC; fig|1335757.3.peg.1544; -.
DR   KO; K01626; -.
DR   OrthoDB; 853329at2; -.
DR   BioCyc; SSP1335757:G1HLC-1571-MONOMER; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000017640; Chromosome.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017640};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361, ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN          45..341
FT                   /note="DAHP_synth_1"
FT                   /evidence="ECO:0000259|Pfam:PF00793"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   357 AA;  38659 MW;  AE628E91FCCB09FA CRC64;
     MSETSIDNLN VLSQDPLPTP ADLKARQPLS DRAMETVQAG RQAVEAILDG QDPRMLVVIG
     PCSIHDLEAA KDYARRLKGL HDELSDSLFI VMRVYFEKPR TTVGWKGLIN DPYMDDSFDI
     EEGLRRAREL LLYMAELGLP AGTEALDPIT PQYLGDLISW TAIGARTTES QTHREMASGL
     STAVGFKNGT DGSLDVAINA MRSAASPHSF LGITQHDGRS AIIRTAGNRY GHVVLRGGDQ
     PNYDSVSIAL CEKALADEGL SACLMVDCSH ANSSKDPGLQ PLVMDNLVNQ IVEGNRSIVA
     AMIESHIGWG KQKLGDDPSA LEYGVSITDG CIDWATTERM LREAAGKLSQ PLQARIA
//
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