ID U5TMV3_COWPX Unreviewed; 370 AA.
AC U5TMV3;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Soluble interferon alpha/beta receptor OPG204 {ECO:0000256|ARBA:ARBA00041012};
GN Name=CPXV212 {ECO:0000313|EMBL:AGZ00919.1};
OS Cowpox virus (CPV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX NCBI_TaxID=10243 {ECO:0000313|EMBL:AGZ00919.1, ECO:0000313|Proteomes:UP000098423};
OH NCBI_TaxID=10129; Apodemus sylvaticus (European woodmouse).
OH NCBI_TaxID=9913; Bos taurus (Bovine).
OH NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9785; Loxodonta africana (African elephant).
OH NCBI_TaxID=29092; Microtus agrestis (Short-tailed field vole).
OH NCBI_TaxID=10090; Mus musculus (Mouse).
OH NCBI_TaxID=447135; Myodes glareolus (Bank vole) (Clethrionomys glareolus).
RN [1] {ECO:0000313|Proteomes:UP000097203, ECO:0000313|Proteomes:UP000097445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BeaBer04/1 {ECO:0000313|EMBL:AGY97237.1}, CatBer07/1
RC {ECO:0000313|EMBL:AGY99587.1}, CatPot07/1
RC {ECO:0000313|EMBL:AGZ00449.1}, EleGri07/1
RC {ECO:0000313|EMBL:AGZ00502.1}, HumBer07/1
RC {ECO:0000313|EMBL:AGZ00919.1}, HumGri07/1
RC {ECO:0000313|EMBL:AGZ01344.1}, HumLan08/1
RC {ECO:0000313|EMBL:AGY97294.1}, HumMag07/1
RC {ECO:0000313|EMBL:AGY97947.1}, JagKre08/1
RC {ECO:0000313|EMBL:AGY98367.1}, JagKre08/2
RC {ECO:0000313|EMBL:AGY98584.1}, MonKre08/4
RC {ECO:0000313|EMBL:AGY99020.1}, and RatHei09/1
RC {ECO:0000313|EMBL:AGY99861.1};
RA Dabrowski P.W., Radonic A., Kurth A., Nitsche A.;
RT "Genome-wide comparison of cowpoxviruses reveals a new clade related to
RT Variola virus.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Interacts with host IFNA1. {ECO:0000256|ARBA:ARBA00038761}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC {ECO:0000256|ARBA:ARBA00009752}.
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DR EMBL; KC813491; AGY97237.1; -; Genomic_DNA.
DR EMBL; KC813492; AGY97294.1; -; Genomic_DNA.
DR EMBL; KC813495; AGY97947.1; -; Genomic_DNA.
DR EMBL; KC813497; AGY98367.1; -; Genomic_DNA.
DR EMBL; KC813498; AGY98584.1; -; Genomic_DNA.
DR EMBL; KC813500; AGY99020.1; -; Genomic_DNA.
DR EMBL; KC813502; AGY99587.1; -; Genomic_DNA.
DR EMBL; KC813504; AGY99861.1; -; Genomic_DNA.
DR EMBL; KC813506; AGZ00449.1; -; Genomic_DNA.
DR EMBL; KC813507; AGZ00502.1; -; Genomic_DNA.
DR EMBL; KC813509; AGZ00919.1; -; Genomic_DNA.
DR EMBL; KC813511; AGZ01344.1; -; Genomic_DNA.
DR Proteomes; UP000097203; Genome.
DR Proteomes; UP000097445; Genome.
DR Proteomes; UP000098423; Genome.
DR Proteomes; UP000101132; Genome.
DR Proteomes; UP000115255; Genome.
DR Proteomes; UP000131496; Genome.
DR Proteomes; UP000137723; Genome.
DR Proteomes; UP000151407; Genome.
DR Proteomes; UP000159199; Genome.
DR Proteomes; UP000163863; Genome.
DR Proteomes; UP000172256; Genome.
DR Proteomes; UP000173670; Genome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR015621; IL-1_rcpt_fam.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11890:SF44; X-LINKED INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 2; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13895; Ig_2; 1.
DR SMART; SM00409; IG; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 3: Inferred from homology;
KW Early protein {ECO:0000256|ARBA:ARBA00022518};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host interferon signaling pathway by virus
KW {ECO:0000256|ARBA:ARBA00022830};
KW Interferon antiviral system evasion {ECO:0000256|ARBA:ARBA00022830};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT DOMAIN 174..256
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 265..364
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 370 AA; 42589 MW; D2E6A23DE391DC89 CRC64;
MCVKLILYNY LSAGIMKMTM KMMVHIYFVS LSLSLLLFHS YAIDIENEIT EFFNKMKDTL
PAKDSKWLNP ACMFGGTMND MAAIGEPFSA KCPPIEDSLL SHRYKDKDNV VNWEKIGKTR
RPLNRRVKNG DLWIANYTSN DSRRRYLCTV ITKNGDCIQG IVRSHVRKPS SCIPEIYELG
THDKYGIDLY CGIIYAKHYN NITWYKDNKE INIDDIKYSQ TGKELIIHNP ALEDSGRYDC
YVHYDDVRIK NDIVVSRCKI LTVIPSQDHR FKLILDPKIN VTIGEPANIT CTAVSTSLLV
DDVLIEWENP SGWLIGFDFD VYSVLTSRGG ITEATLYFEN VTEEYIGNTY KCRGHNYYFE
KTLTTTVVLE
//
