ID U5W085_9ACTN Unreviewed; 736 AA.
AC U5W085;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) {ECO:0000313|EMBL:AGZ42442.1};
GN ORFNames=AFR_20850 {ECO:0000313|EMBL:AGZ42442.1};
OS Actinoplanes friuliensis DSM 7358.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=1246995 {ECO:0000313|EMBL:AGZ42442.1, ECO:0000313|Proteomes:UP000017746};
RN [1] {ECO:0000313|EMBL:AGZ42442.1, ECO:0000313|Proteomes:UP000017746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7358 {ECO:0000313|EMBL:AGZ42442.1,
RC ECO:0000313|Proteomes:UP000017746};
RX PubMed=24637369; DOI=10.1016/j.jbiotec.2014.03.011;
RA Ruckert C., Szczepanowski R., Albersmeier A., Goesmann A., Fischer N.,
RA Steinkamper A., Puhler A., Biener R., Schwartz D., Kalinowski J.;
RT "Complete genome sequence of the actinobacterium Actinoplanes friuliensis
RT HAG 010964, producer of the lipopeptide antibiotic friulimycin.";
RL J. Biotechnol. 178:41-42(2014).
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DR EMBL; CP006272; AGZ42442.1; -; Genomic_DNA.
DR RefSeq; WP_023362814.1; NC_022657.1.
DR AlphaFoldDB; U5W085; -.
DR STRING; 1246995.AFR_20850; -.
DR KEGG; afs:AFR_20850; -.
DR PATRIC; fig|1246995.3.peg.4227; -.
DR eggNOG; COG3852; Bacteria.
DR eggNOG; COG5001; Bacteria.
DR HOGENOM; CLU_000445_70_49_11; -.
DR Proteomes; UP000017746; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF00989; PAS; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000017746};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 181..236
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 255..306
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 335..464
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 473..729
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 736 AA; 79389 MW; DDF5A6D7ACCB2C28 CRC64;
MHGADFDDHT ADYWARQIRI GSAIAAGVTL LGCVRVAADW APADRWLIPW ALGAVVLQLA
ALALPWLRLA RDVRIRRSLV LWLVAELPLL FQFARIDDDG LMFYLPGSAL IIVATAALYP
PLVVVGLGVL ALVGYLALLP AVTAGNAVSI VSLLAIMFCL VALTAINSRS RRRLDERRKA
AEHRTELLLE AASDAVFAID VAGEIRYASP SAQRILGMGT DQLSGVALKT LAHPDELAGL
GAWMSDLWRV PGGTSRTEAR LRRPDGTWMH LDVIGTNRLD DPSLRSAVIS LRDIGRRKEL
EDQLSLQAFT DSLTGLPNRA LFRDRLEQAA RRPGSDVTVL LIDLDDFKLV NDNLGHNAGD
ELLATLAGRL RGEMRAGDTL ARLGGDEFAI LAEDLDAAEA AVLAERLLTA GREQVRLGSR
DVSCSLSIGI ATGDLPAEQL LRNADLAMYA AKRSGRNAYQ LFSPSMSRSV LEEAQQRVDM
ERGLEQEQFV VLYQPVVDMT TQRLTGVEAL VRWRHPDDGL LSPYQFIANA EANGLIVPLG
RWVLREACAQ LARWRRETPA AAGLKINVNL SARQFQYAGL VGDVAAALAD AGIPASALTL
EITESMLMED VTGAIETLGA LRQLGVRLAI DDFGTGYSSL NYLKQLPVDI IKIDRTFVES
VDTDADDVAL VDAVVGLGQA LRLQTVAEGI ETDGQWAMLQ QIGCDQGQGY LFGRPGDAAS
VAALLARDAA AAPAGV
//
