ID U5W180_9ACTN Unreviewed; 772 AA.
AC U5W180;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Putative signaling protein {ECO:0000313|EMBL:AGZ41715.1};
GN ORFNames=AFR_17185 {ECO:0000313|EMBL:AGZ41715.1};
OS Actinoplanes friuliensis DSM 7358.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=1246995 {ECO:0000313|EMBL:AGZ41715.1, ECO:0000313|Proteomes:UP000017746};
RN [1] {ECO:0000313|EMBL:AGZ41715.1, ECO:0000313|Proteomes:UP000017746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7358 {ECO:0000313|EMBL:AGZ41715.1,
RC ECO:0000313|Proteomes:UP000017746};
RX PubMed=24637369; DOI=10.1016/j.jbiotec.2014.03.011;
RA Ruckert C., Szczepanowski R., Albersmeier A., Goesmann A., Fischer N.,
RA Steinkamper A., Puhler A., Biener R., Schwartz D., Kalinowski J.;
RT "Complete genome sequence of the actinobacterium Actinoplanes friuliensis
RT HAG 010964, producer of the lipopeptide antibiotic friulimycin.";
RL J. Biotechnol. 178:41-42(2014).
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DR EMBL; CP006272; AGZ41715.1; -; Genomic_DNA.
DR AlphaFoldDB; U5W180; -.
DR STRING; 1246995.AFR_17185; -.
DR KEGG; afs:AFR_17185; -.
DR PATRIC; fig|1246995.3.peg.3485; -.
DR eggNOG; COG5001; Bacteria.
DR HOGENOM; CLU_000445_129_3_11; -.
DR OrthoDB; 3274485at2; -.
DR Proteomes; UP000017746; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR PANTHER; PTHR33121:SF85; CYCLIC DI-GMP PHOSPHODIESTERASE PDEK-RELATED; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000017746};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 5..23
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 29..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 67..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 365..496
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 505..760
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 772 AA; 83648 MW; 3A73A415A7B250D4 CRC64;
MHPRAALAAG GALLVVSFLW LGIGLGHVWA YPVLGWLPLP VLSLLAARAC RQTGRRVELG
IATRRFWTQL GHATTIMAVG IVSNAYDAVG GPEPSQRLST LTLSVYLLAL AVLLWALLRL
PTWQRSRSDW ARFGLDTCIV LITSGVFVWH FSLRKVEVWT EQTGSAMPLL ALSVVGFISV
VTFVKVAFAG AGCLDRQSVR LLSYGTAASA LFGGLSPFLV DRPYLSSSFV AVSVAAFAVQ
LAAVRQLHSE VQIAPVRTKP HRASVVPYLA VAATDALLLS IGTSHPAEIT VMQISAVSLT
ALVIVRQIVT MRENVRLLNT VDANLGQLRR YQDQLEHQAT HDTLTGIPNR ALLEREIAAL
LVTGDDFHLA LLDVDDFKSI NDRLGHGRGD QMLVEFSGRL QREIRREDTV ARLGGDEFVV
LVRDGDEAAL PTLLTRLLET VERPVPLDGQ DIVVQASIGV TRSRPGDDPH ELLRRADVAM
YSAKAAGGNR WTRFDEVMDR EADREARLGR DLRGAVARGE LFLLYQPLVE LPHGRLAGVE
ALLRWQHPEH GLVPPDVFVP IAERNGAIVE VGRWVLEEAC RQAAAWQHRY GERAPGKVSI
NVSARQLAEP GFVAEVAAVL SSTGADRRRL MIEVTETAVL GADTAMAAVR ELRGLGLQVA
LDDFGTGNSS LSLLVDCPVD VLKVDKSFVD GVTGDGPQAL VVQSLITVAQ GMRVEAVAEG
VETPEQAQRL YEAGYRLVQG FLYDRPLSAD DVAQGIEAAT NSWYAATPSG SA
//
