ID U5W2R2_9ACTN Unreviewed; 316 AA.
AC U5W2R2;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=RNA polymerase factor sigma-70 {ECO:0000313|EMBL:AGZ43518.1};
DE EC=2.7.7.6 {ECO:0000313|EMBL:AGZ43518.1};
GN ORFNames=AFR_26280 {ECO:0000313|EMBL:AGZ43518.1};
OS Actinoplanes friuliensis DSM 7358.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=1246995 {ECO:0000313|EMBL:AGZ43518.1, ECO:0000313|Proteomes:UP000017746};
RN [1] {ECO:0000313|EMBL:AGZ43518.1, ECO:0000313|Proteomes:UP000017746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7358 {ECO:0000313|EMBL:AGZ43518.1,
RC ECO:0000313|Proteomes:UP000017746};
RX PubMed=24637369; DOI=10.1016/j.jbiotec.2014.03.011;
RA Ruckert C., Szczepanowski R., Albersmeier A., Goesmann A., Fischer N.,
RA Steinkamper A., Puhler A., Biener R., Schwartz D., Kalinowski J.;
RT "Complete genome sequence of the actinobacterium Actinoplanes friuliensis
RT HAG 010964, producer of the lipopeptide antibiotic friulimycin.";
RL J. Biotechnol. 178:41-42(2014).
CC -!- SUBUNIT: Interacts transiently with the RNA polymerase catalytic core
CC formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1
CC omega subunit) to form the RNA polymerase holoenzyme that can initiate
CC transcription. {ECO:0000256|ARBA:ARBA00011344}.
CC -!- SIMILARITY: Belongs to the sigma-70 factor family. ECF subfamily.
CC {ECO:0000256|ARBA:ARBA00010641}.
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DR EMBL; CP006272; AGZ43518.1; -; Genomic_DNA.
DR AlphaFoldDB; U5W2R2; -.
DR STRING; 1246995.AFR_26280; -.
DR KEGG; afs:AFR_26280; -.
DR PATRIC; fig|1246995.3.peg.5326; -.
DR eggNOG; COG1595; Bacteria.
DR eggNOG; COG3631; Bacteria.
DR HOGENOM; CLU_043648_0_0_11; -.
DR Proteomes; UP000017746; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0016987; F:sigma factor activity; IEA:InterPro.
DR GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd06171; Sigma70_r4; 1.
DR Gene3D; 1.10.1740.10; -; 1.
DR Gene3D; 3.10.450.50; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR039425; RNA_pol_sigma-70-like.
DR InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR InterPro; IPR014305; RNA_pol_sigma-G_actinobac.
DR InterPro; IPR007627; RNA_pol_sigma70_r2.
DR InterPro; IPR013249; RNA_pol_sigma70_r4_t2.
DR InterPro; IPR013325; RNA_pol_sigma_r2.
DR InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR InterPro; IPR037401; SnoaL-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR02937; sigma70-ECF; 1.
DR NCBIfam; TIGR02960; SigX5; 1.
DR PANTHER; PTHR43133:SF46; ECF RNA POLYMERASE SIGMA FACTOR SIGG; 1.
DR PANTHER; PTHR43133; RNA POLYMERASE ECF-TYPE SIGMA FACTO; 1.
DR Pfam; PF04542; Sigma70_r2; 1.
DR Pfam; PF08281; Sigma70_r4_2; 1.
DR Pfam; PF12680; SnoaL_2; 1.
DR SUPFAM; SSF54427; NTF2-like; 1.
DR SUPFAM; SSF88946; Sigma2 domain of RNA polymerase sigma factors; 1.
DR SUPFAM; SSF88659; Sigma3 and sigma4 domains of RNA polymerase sigma factors; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000313|EMBL:AGZ43518.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000017746};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000313|EMBL:AGZ43518.1}.
FT DOMAIN 7..71
FT /note="RNA polymerase sigma-70 region 2"
FT /evidence="ECO:0000259|Pfam:PF04542"
FT DOMAIN 124..174
FT /note="RNA polymerase sigma factor 70 region 4 type 2"
FT /evidence="ECO:0000259|Pfam:PF08281"
FT DOMAIN 194..289
FT /note="SnoaL-like"
FT /evidence="ECO:0000259|Pfam:PF12680"
SQ SEQUENCE 316 AA; 34650 MW; E21756CC1F5E119F CRC64;
MQAEDFRVEL TGYAYRMLGS GSEAEDAVQE TLLRAWKNAG RYDEERGSLR TWLYRIATNV
CLDMLRSAQR RARPVDLGPA VEAGAPLGVP LPESTWVRPI ADARVLPGAD DPAEQAVRRE
SVRLAFVAAL QKLSPRQRAV LILRDVLGWQ AAEVAALLET SEASVTSALQ RARASVRRDA
PVAPLEPDAE ALLDRYCRAF ARYDVTAMIA LLHEDATMSM PPFTWWLRGR EAIADVLRHG
GGSCEGARMV PVAMNGTTAF WQERPTGPGG AFEPFALMLF ETAGGLITEI VTFLDERPMS
SGPLPRIPSE NEEDSS
//
