ID U5W6F5_9ACTN Unreviewed; 374 AA.
AC U5W6F5;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=GH26 domain-containing protein {ECO:0000259|PROSITE:PS51764};
GN ORFNames=AFR_32355 {ECO:0000313|EMBL:AGZ44729.1};
OS Actinoplanes friuliensis DSM 7358.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=1246995 {ECO:0000313|EMBL:AGZ44729.1, ECO:0000313|Proteomes:UP000017746};
RN [1] {ECO:0000313|EMBL:AGZ44729.1, ECO:0000313|Proteomes:UP000017746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7358 {ECO:0000313|EMBL:AGZ44729.1,
RC ECO:0000313|Proteomes:UP000017746};
RX PubMed=24637369; DOI=10.1016/j.jbiotec.2014.03.011;
RA Ruckert C., Szczepanowski R., Albersmeier A., Goesmann A., Fischer N.,
RA Steinkamper A., Puhler A., Biener R., Schwartz D., Kalinowski J.;
RT "Complete genome sequence of the actinobacterium Actinoplanes friuliensis
RT HAG 010964, producer of the lipopeptide antibiotic friulimycin.";
RL J. Biotechnol. 178:41-42(2014).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 26 family.
CC {ECO:0000256|ARBA:ARBA00007754, ECO:0000256|PROSITE-ProRule:PRU01100}.
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DR EMBL; CP006272; AGZ44729.1; -; Genomic_DNA.
DR RefSeq; WP_023561061.1; NC_022657.1.
DR AlphaFoldDB; U5W6F5; -.
DR STRING; 1246995.AFR_32355; -.
DR KEGG; afs:AFR_32355; -.
DR PATRIC; fig|1246995.3.peg.6548; -.
DR eggNOG; COG4124; Bacteria.
DR HOGENOM; CLU_033703_0_0_11; -.
DR OrthoDB; 3279376at2; -.
DR Proteomes; UP000017746; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016985; F:mannan endo-1,4-beta-mannosidase activity; IEA:InterPro.
DR GO; GO:0006080; P:substituted mannan metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR022790; GH26_dom.
DR InterPro; IPR000805; Glyco_hydro_26.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR40079:SF4; GH26 DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR40079; MANNAN ENDO-1,4-BETA-MANNOSIDASE E-RELATED; 1.
DR Pfam; PF02156; Glyco_hydro_26; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR PROSITE; PS51764; GH26; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|PROSITE-
KW ProRule:PRU01100};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01100}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000017746};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..356
FT /note="GH26"
FT /evidence="ECO:0000259|PROSITE:PS51764"
FT REGION 33..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 190
FT /note="Proton donor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01100"
FT ACT_SITE 302
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01100"
SQ SEQUENCE 374 AA; 40144 MW; 97BBA678EFA17DDD CRC64;
MADERPSGRR HWLVAGIAVV VVAAGVGVGL ATTDPDKPVA VPSSAPSSAA ASPVVTSSVQ
SRSARKLIGL SRANGTWPGP NGMSGVNGDP LFDTAHVKAF CTARGRACRV AQTYTDRTSW
QSMTAGSSWT FDLFSDFEGM LVVSQGLVPI GATADLAACA AGDHDQDWKN FGSLMTRYGR
GDSVVRLGWE FNETTSPWRA DDPAVWIACY RRAATNIRAT NPEVLLDWTI NAHGTPAGTC
GGVSTNCYPG DDYVDIIGID NYDHYPWSSS KAVFDKAATD PEGLTWLHDF ARDHDKLFSV
GEWGVVPTGD AGQENQYFVQ WMHDWFAAHA STLAYEAYFS DCGEGGVQSS LYRTDAACLK
NPKSAAQYRA LFGS
//
