ID U5W9Q7_9ACTN Unreviewed; 340 AA.
AC U5W9Q7;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=LacI family transcriptional regulator {ECO:0000313|EMBL:AGZ44646.1};
GN ORFNames=AFR_31930 {ECO:0000313|EMBL:AGZ44646.1};
OS Actinoplanes friuliensis DSM 7358.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=1246995 {ECO:0000313|EMBL:AGZ44646.1, ECO:0000313|Proteomes:UP000017746};
RN [1] {ECO:0000313|EMBL:AGZ44646.1, ECO:0000313|Proteomes:UP000017746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7358 {ECO:0000313|EMBL:AGZ44646.1,
RC ECO:0000313|Proteomes:UP000017746};
RX PubMed=24637369; DOI=10.1016/j.jbiotec.2014.03.011;
RA Ruckert C., Szczepanowski R., Albersmeier A., Goesmann A., Fischer N.,
RA Steinkamper A., Puhler A., Biener R., Schwartz D., Kalinowski J.;
RT "Complete genome sequence of the actinobacterium Actinoplanes friuliensis
RT HAG 010964, producer of the lipopeptide antibiotic friulimycin.";
RL J. Biotechnol. 178:41-42(2014).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP006272; AGZ44646.1; -; Genomic_DNA.
DR RefSeq; WP_023560979.1; NC_022657.1.
DR AlphaFoldDB; U5W9Q7; -.
DR STRING; 1246995.AFR_31930; -.
DR KEGG; afs:AFR_31930; -.
DR PATRIC; fig|1246995.3.peg.6463; -.
DR eggNOG; COG1609; Bacteria.
DR HOGENOM; CLU_037628_6_0_11; -.
DR OrthoDB; 3510266at2; -.
DR Proteomes; UP000017746; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd01392; HTH_LacI; 1.
DR CDD; cd06267; PBP1_LacI_sugar_binding-like; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR000843; HTH_LacI.
DR InterPro; IPR046335; LacI/GalR-like_sensor.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR30146:SF121; HTH-TYPE TRANSCRIPTIONAL REPRESSOR CYTR; 1.
DR PANTHER; PTHR30146; LACI-RELATED TRANSCRIPTIONAL REPRESSOR; 1.
DR Pfam; PF00356; LacI; 1.
DR Pfam; PF13377; Peripla_BP_3; 1.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50943; HTH_CROC1; 1.
DR PROSITE; PS00356; HTH_LACI_1; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000017746};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 3..57
FT /note="HTH lacI-type"
FT /evidence="ECO:0000259|PROSITE:PS50932"
FT DOMAIN 3..47
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000259|PROSITE:PS50943"
SQ SEQUENCE 340 AA; 36065 MW; CB20EEA014808DA5 CRC64;
MPITIADVAA RAKVSKTTVS RVLNGKGELD ESTAARVRKV IEEMGYVPSS RAVGLARGRT
RVVGMLVPSL TWPWIGDVLQ GAVDVLETER YGLLLFTCNR GEESMRQFGA QVSAKSFDGL
LVIEPEGTLD YIATLHARGL PVVLIDDRDV QPVQIPSVGT TNHTGAGAAA RHLLEIGRHK
PLVIAGPERF GCTAQRLDGF AAVYAEAGHP VTADRVLPGD FTIACGFEAV QSAYEAGLEF
DAIFAHNDLS ATGAMQAVLD SGRRIPQDVA VVGFDDIPMA AHTQPPLTTV HQPLREMGEA
AARTLLAHFE GSPLPNRPTV IPATFTARGS TGAGPYAEPS
//
