ID U5WB40_9ACTN Unreviewed; 2352 AA.
AC U5WB40;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=Modular polyketide synthase {ECO:0000313|EMBL:AGZ46207.1};
GN ORFNames=AFR_39765 {ECO:0000313|EMBL:AGZ46207.1};
OS Actinoplanes friuliensis DSM 7358.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=1246995 {ECO:0000313|EMBL:AGZ46207.1, ECO:0000313|Proteomes:UP000017746};
RN [1] {ECO:0000313|EMBL:AGZ46207.1, ECO:0000313|Proteomes:UP000017746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7358 {ECO:0000313|EMBL:AGZ46207.1,
RC ECO:0000313|Proteomes:UP000017746};
RX PubMed=24637369; DOI=10.1016/j.jbiotec.2014.03.011;
RA Ruckert C., Szczepanowski R., Albersmeier A., Goesmann A., Fischer N.,
RA Steinkamper A., Puhler A., Biener R., Schwartz D., Kalinowski J.;
RT "Complete genome sequence of the actinobacterium Actinoplanes friuliensis
RT HAG 010964, producer of the lipopeptide antibiotic friulimycin.";
RL J. Biotechnol. 178:41-42(2014).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP006272; AGZ46207.1; -; Genomic_DNA.
DR STRING; 1246995.AFR_39765; -.
DR KEGG; afs:AFR_39765; -.
DR PATRIC; fig|1246995.3.peg.8045; -.
DR eggNOG; COG1028; Bacteria.
DR eggNOG; COG2070; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_30_1_11; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000017746; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08953; KR_2_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.20.20.70; Aldolase class I; 2.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR004136; NMO.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43074; OMEGA-3 POLYUNSATURATED FATTY ACID SYNTHASE PFAB-RELATED; 1.
DR PANTHER; PTHR43074:SF1; PKS_AT DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF03060; NMO; 1.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000017746};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 642..1087
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1773..1856
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2352 AA; 243329 MW; 0710FE1DA1BA055B CRC64;
MRSLVLAVSG GTGLEASPHQ VTAAVQAGGT GVLDLGSGDA WSLRVLARTA RRASEGFGVR
VTAACAATPS DLDRLGGSTV DLVVLTADAG WDVTALAERY RVLVEVTDLA EAQAAADAGA
HGVIGRGMES GGRVSALSSF VLLQQLAGIG LPVWVAGGIG PHTAAACVVG GAAGVLLDTQ
LLLLPESAVA DQVTAVVRRM DGTEPVLQDG HRVFVNAGEP LPIGQDGWLA ADFAGRYADT
GAAVRGVRDA VVDALGHADA GEALSPGSPL AQALGVRLPV AQGPMTRVSD VAGFAASVAD
GGGLPFIALA LANAEQSRRM LTETAAALGD RPWGVGVLGF APEQLRNAQI DVIREIKPAV
AIIAGGRPAQ AKGLEADGIS SFLHVPSPGL LRQFLQAGSR KLIFEGAECG GHVGPRASFP
LWEAQLGVLT EFLTGRGDDV AAELQIFFAG GIHDERSAAM VAAMAGPLTR RGVRVGVLMG
TAYLFTEEAV THGAIQPLFQ QQAIDATATA LLETAPGHAT RCLQSGFVDD FHSLRDQLET
AGVENRVVWE QLEMLNVGRL RIASKGLTRD GDQLVTVDDD TQAAEGLFMA GQVAVLREAA
TTVAALHDQV TTVAAAGHAD RVTELRADLG LDPVLEPVTA DPLDIAIVGM ACVFPGSPDL
ASFWETVVSS ANAVGDVPAD RWDVETYYAP EVGPGQAGRI TVSKWGGFID PVPFDAIKYG
IPPAALASID PTQLLALEIS HRALVDAGYA YDSGADHSKT GVVFGAEAGS DMSQTQTLRT
LLPGYLGDVP AQMEDLLPTV TEDTFPGVLA NVIAGRVANR LDLGGPNYTV DAACASSLAA
MDSACKELLA GDSDLMICGG ADLHNGINDY LMFTSAHALS PTGRCRTFDS TGDGIALGEG
VAAVVLKRLS DAERDGDRVY AVIKGLGGAS DGRALGLTAP RAEGQRRALD RAYAGAGVTP
SQVGLVEAHG TGTVVGDRTE LETLTRLFTE SGARPGGAVL GSVKSQIGHT KCAAGMAGVI
KAALALHTGV KPPTIGLTRP NPAWNPETSP FAFHTETRPW AAPAEERVAG VSAFGFGGTN
FHVVLGAHAP TADPRHSQQQ WPVELFTFRG ATVENARRGV RKLLDKLPAG GRLRELAATT
AKESDPRTGP VRIAVVATDI DDLDTLLRRA LDGEHDPRKG LIQPPAAAGP GEVAFLFPGQ
GSQKPGALAD LFVAFPELHE YLELGRDWAD LLFPPTAFDD ATEQAQQDRI RDTRVAQPVL
GIGGLAVDHV LRRLGVRPDM AGGHSYGELV ALCTTGAFDP ATLLDLSRER AAAILAAAGD
DPGTMAAVSG TAEEIRAALT AAGLDGEVVL ANHNAPTQVV ISGPTAAIGR AIPALKEAGL
RARGIPVAAA FHSPVVAGGS ATFAGVLADR PIGTPDVPVW SNTTAEPYPG DADGVRAGLA
AQIGAPVRFV EQIEAMYAAG ARTFVEAGPG QVLANLVGAV LGDRDHLVVT VDGRPGQGLR
ALLTAAAELA CAGVPVQTGW LFAGRDVTGP VSPGTGNRPT WTVDGQVVRD RNGDCLPGGM
TPARRIEIEE FTMTAVQGPE SARDSRSDLV SEFLRTSRDL IATQRDVLLA YLGDAPAAGR
MVWQPAEVTA VAATPATPVT QVAPVSPAPA PVSMQVAAVH YPTVAETEAV LTGLDVQGAV
LSVISERTGY PEELIELDLD LEADLSVDSI KRAEVAGEVA NRLGLSVEGD ESELEELVKA
RTVRAMVSWL DLRINVTVTP VAPVVAVAAQ PAAIVMDVQG AVLTVISERT GYPEELIELD
LDLEADLSVD SIKRAEVAGE VANRLGLSVE GDESELEELV KARTVRAMVS WLDLKINAPA
ETVAALEVRA AESEAPPPLG IAPQRLVSRL DAVAATGDTE LTGARFLITG GDAETAALAA
LLADAGATGV TGSTATDPAG FDGIVLLDGL TEGAGNLLPD AFGFLKNALT GAPRWLVAAG
PEGGSPQTDG MTGLFRTIAR EYPETIARYV EVPDAGAVLA ELTDSTTAPV VLHRGGERLV
GELTPVGLGM LADGGAGPAG EGAAEAQAIG LDQDSVVVLI GGARGITPWF ARTVAATARC
RVELVGRTPL PQTDEDPELA AAPDKAALRS ALARRGMRSP AEIDRTASAI LAAREVNATV
AELGELGAEV RYHSLDVRDD EATHRLIKQI HDEYGRLDGL VYAAGIIEDK LVADKDPASF
DRVFRTKVDG ARSVLDALDA CGAEPRFVVM FGSIAAAYGN RGQSDYAAAN DALDAMGARW
SATTGHRALT VHWGPWAPVG AHGGMVTPEL TAEYARRGIG LIDPEEGALS LLRELAWGDA
ATTSVVLTAS GW
//