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Database: UniProt
Entry: U5WB40_9ACTN
LinkDB: U5WB40_9ACTN
Original site: U5WB40_9ACTN 
ID   U5WB40_9ACTN            Unreviewed;      2352 AA.
AC   U5WB40;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   SubName: Full=Modular polyketide synthase {ECO:0000313|EMBL:AGZ46207.1};
GN   ORFNames=AFR_39765 {ECO:0000313|EMBL:AGZ46207.1};
OS   Actinoplanes friuliensis DSM 7358.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Actinoplanes.
OX   NCBI_TaxID=1246995 {ECO:0000313|EMBL:AGZ46207.1, ECO:0000313|Proteomes:UP000017746};
RN   [1] {ECO:0000313|EMBL:AGZ46207.1, ECO:0000313|Proteomes:UP000017746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 7358 {ECO:0000313|EMBL:AGZ46207.1,
RC   ECO:0000313|Proteomes:UP000017746};
RX   PubMed=24637369; DOI=10.1016/j.jbiotec.2014.03.011;
RA   Ruckert C., Szczepanowski R., Albersmeier A., Goesmann A., Fischer N.,
RA   Steinkamper A., Puhler A., Biener R., Schwartz D., Kalinowski J.;
RT   "Complete genome sequence of the actinobacterium Actinoplanes friuliensis
RT   HAG 010964, producer of the lipopeptide antibiotic friulimycin.";
RL   J. Biotechnol. 178:41-42(2014).
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DR   EMBL; CP006272; AGZ46207.1; -; Genomic_DNA.
DR   STRING; 1246995.AFR_39765; -.
DR   KEGG; afs:AFR_39765; -.
DR   PATRIC; fig|1246995.3.peg.8045; -.
DR   eggNOG; COG1028; Bacteria.
DR   eggNOG; COG2070; Bacteria.
DR   eggNOG; COG3321; Bacteria.
DR   HOGENOM; CLU_000022_30_1_11; -.
DR   OrthoDB; 9778690at2; -.
DR   Proteomes; UP000017746; Chromosome.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   CDD; cd08953; KR_2_SDR_x; 1.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 2.
DR   Gene3D; 3.20.20.70; Aldolase class I; 2.
DR   Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR004136; NMO.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43074; OMEGA-3 POLYUNSATURATED FATTY ACID SYNTHASE PFAB-RELATED; 1.
DR   PANTHER; PTHR43074:SF1; PKS_AT DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF03060; NMO; 1.
DR   Pfam; PF00550; PP-binding; 2.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF47336; ACP-like; 2.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00606; KS3_1; 1.
DR   PROSITE; PS52004; KS3_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000017746};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          642..1087
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          1773..1856
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   2352 AA;  243329 MW;  0710FE1DA1BA055B CRC64;
     MRSLVLAVSG GTGLEASPHQ VTAAVQAGGT GVLDLGSGDA WSLRVLARTA RRASEGFGVR
     VTAACAATPS DLDRLGGSTV DLVVLTADAG WDVTALAERY RVLVEVTDLA EAQAAADAGA
     HGVIGRGMES GGRVSALSSF VLLQQLAGIG LPVWVAGGIG PHTAAACVVG GAAGVLLDTQ
     LLLLPESAVA DQVTAVVRRM DGTEPVLQDG HRVFVNAGEP LPIGQDGWLA ADFAGRYADT
     GAAVRGVRDA VVDALGHADA GEALSPGSPL AQALGVRLPV AQGPMTRVSD VAGFAASVAD
     GGGLPFIALA LANAEQSRRM LTETAAALGD RPWGVGVLGF APEQLRNAQI DVIREIKPAV
     AIIAGGRPAQ AKGLEADGIS SFLHVPSPGL LRQFLQAGSR KLIFEGAECG GHVGPRASFP
     LWEAQLGVLT EFLTGRGDDV AAELQIFFAG GIHDERSAAM VAAMAGPLTR RGVRVGVLMG
     TAYLFTEEAV THGAIQPLFQ QQAIDATATA LLETAPGHAT RCLQSGFVDD FHSLRDQLET
     AGVENRVVWE QLEMLNVGRL RIASKGLTRD GDQLVTVDDD TQAAEGLFMA GQVAVLREAA
     TTVAALHDQV TTVAAAGHAD RVTELRADLG LDPVLEPVTA DPLDIAIVGM ACVFPGSPDL
     ASFWETVVSS ANAVGDVPAD RWDVETYYAP EVGPGQAGRI TVSKWGGFID PVPFDAIKYG
     IPPAALASID PTQLLALEIS HRALVDAGYA YDSGADHSKT GVVFGAEAGS DMSQTQTLRT
     LLPGYLGDVP AQMEDLLPTV TEDTFPGVLA NVIAGRVANR LDLGGPNYTV DAACASSLAA
     MDSACKELLA GDSDLMICGG ADLHNGINDY LMFTSAHALS PTGRCRTFDS TGDGIALGEG
     VAAVVLKRLS DAERDGDRVY AVIKGLGGAS DGRALGLTAP RAEGQRRALD RAYAGAGVTP
     SQVGLVEAHG TGTVVGDRTE LETLTRLFTE SGARPGGAVL GSVKSQIGHT KCAAGMAGVI
     KAALALHTGV KPPTIGLTRP NPAWNPETSP FAFHTETRPW AAPAEERVAG VSAFGFGGTN
     FHVVLGAHAP TADPRHSQQQ WPVELFTFRG ATVENARRGV RKLLDKLPAG GRLRELAATT
     AKESDPRTGP VRIAVVATDI DDLDTLLRRA LDGEHDPRKG LIQPPAAAGP GEVAFLFPGQ
     GSQKPGALAD LFVAFPELHE YLELGRDWAD LLFPPTAFDD ATEQAQQDRI RDTRVAQPVL
     GIGGLAVDHV LRRLGVRPDM AGGHSYGELV ALCTTGAFDP ATLLDLSRER AAAILAAAGD
     DPGTMAAVSG TAEEIRAALT AAGLDGEVVL ANHNAPTQVV ISGPTAAIGR AIPALKEAGL
     RARGIPVAAA FHSPVVAGGS ATFAGVLADR PIGTPDVPVW SNTTAEPYPG DADGVRAGLA
     AQIGAPVRFV EQIEAMYAAG ARTFVEAGPG QVLANLVGAV LGDRDHLVVT VDGRPGQGLR
     ALLTAAAELA CAGVPVQTGW LFAGRDVTGP VSPGTGNRPT WTVDGQVVRD RNGDCLPGGM
     TPARRIEIEE FTMTAVQGPE SARDSRSDLV SEFLRTSRDL IATQRDVLLA YLGDAPAAGR
     MVWQPAEVTA VAATPATPVT QVAPVSPAPA PVSMQVAAVH YPTVAETEAV LTGLDVQGAV
     LSVISERTGY PEELIELDLD LEADLSVDSI KRAEVAGEVA NRLGLSVEGD ESELEELVKA
     RTVRAMVSWL DLRINVTVTP VAPVVAVAAQ PAAIVMDVQG AVLTVISERT GYPEELIELD
     LDLEADLSVD SIKRAEVAGE VANRLGLSVE GDESELEELV KARTVRAMVS WLDLKINAPA
     ETVAALEVRA AESEAPPPLG IAPQRLVSRL DAVAATGDTE LTGARFLITG GDAETAALAA
     LLADAGATGV TGSTATDPAG FDGIVLLDGL TEGAGNLLPD AFGFLKNALT GAPRWLVAAG
     PEGGSPQTDG MTGLFRTIAR EYPETIARYV EVPDAGAVLA ELTDSTTAPV VLHRGGERLV
     GELTPVGLGM LADGGAGPAG EGAAEAQAIG LDQDSVVVLI GGARGITPWF ARTVAATARC
     RVELVGRTPL PQTDEDPELA AAPDKAALRS ALARRGMRSP AEIDRTASAI LAAREVNATV
     AELGELGAEV RYHSLDVRDD EATHRLIKQI HDEYGRLDGL VYAAGIIEDK LVADKDPASF
     DRVFRTKVDG ARSVLDALDA CGAEPRFVVM FGSIAAAYGN RGQSDYAAAN DALDAMGARW
     SATTGHRALT VHWGPWAPVG AHGGMVTPEL TAEYARRGIG LIDPEEGALS LLRELAWGDA
     ATTSVVLTAS GW
//
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