ID U5WS34_MYCKA Unreviewed; 1111 AA.
AC U5WS34;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Serine/threonine-protein kinase PknK {ECO:0000256|PIRNR:PIRNR000574};
DE EC=2.7.11.1 {ECO:0000256|PIRNR:PIRNR000574};
DE AltName: Full=Protein kinase K {ECO:0000256|PIRNR:PIRNR000574};
GN ORFNames=MKAN_16730 {ECO:0000313|EMBL:AGZ51737.1};
OS Mycobacterium kansasii ATCC 12478.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=557599 {ECO:0000313|EMBL:AGZ51737.1, ECO:0000313|Proteomes:UP000017786};
RN [1] {ECO:0000313|EMBL:AGZ51737.1, ECO:0000313|Proteomes:UP000017786}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12478 {ECO:0000313|EMBL:AGZ51737.1,
RC ECO:0000313|Proteomes:UP000017786};
RG McGill University Mycobacterium genome consortium;
RA Veyrier F.J., Behr M.A.;
RT "Genome sequence of Mycobacterium kansasii.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433,
CC ECO:0000256|PIRNR:PIRNR000574};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775,
CC ECO:0000256|PIRNR:PIRNR000574};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily.
CC {ECO:0000256|PIRNR:PIRNR000574}.
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DR EMBL; CP006835; AGZ51737.1; -; Genomic_DNA.
DR RefSeq; WP_023369774.1; NC_022663.1.
DR AlphaFoldDB; U5WS34; -.
DR GeneID; 29698961; -.
DR KEGG; mkn:MKAN_16730; -.
DR eggNOG; COG0515; Bacteria.
DR eggNOG; COG2909; Bacteria.
DR HOGENOM; CLU_006325_2_0_11; -.
DR OrthoDB; 136365at2; -.
DR Proteomes; UP000017786; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0031326; P:regulation of cellular biosynthetic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR016236; Ser/Thr_kinase_PknK_prd.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR43289; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED; 1.
DR PANTHER; PTHR43289:SF32; SERINE_THREONINE-PROTEIN KINASE PKAB; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF00069; Pkinase; 1.
DR PIRSF; PIRSF000574; Ser/Thr_PK_PknK_prd; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR000574};
KW Kinase {ECO:0000256|PIRNR:PIRNR000574, ECO:0000313|EMBL:AGZ51737.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR000574};
KW Serine/threonine-protein kinase {ECO:0000256|PIRNR:PIRNR000574,
KW ECO:0000313|EMBL:AGZ51737.1}; Transferase {ECO:0000256|PIRNR:PIRNR000574}.
FT DOMAIN 26..283
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 310..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 55
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1111 AA; 120372 MW; 6B82BF16A8884F8E CRC64;
MVDVDSHPTQ RGLVPDIPAE LREAGFDEVA EIGCGGFGVV YRCAQPLLDR TVAVKVLTTD
LDPENLERFL REQHAMGKLS GHPNIVTILQ VGSTVSGRPF IVMPYHAKNS LESLIRRHGP
LDWVETLRMG VKLAGALEAA HRAGILHRDV KPANILLTEY GEPELTDFGI ARMSGGFQTA
TGIITGSPAF TAPEVLEGKA PTPASDLYSL GATLFCALTG HAAFERRSGE KVVAQFLRIT
SQPVPDLREH GLPADVAAVI ERAMARDPAA RPPGAAAFGN ELREVQRISG VAVDEMALPV
DLGVERRTSP VAPSAVRRDT GATPTPPTPT TKYRPPVPTR SLVVRNRLLD VVRAGGLRRL
VLIHAPSGFG KSTLAAQWRE ELSRAPVGVG WLTIDDDDNN VVWFLAHLLE SIRQVRPALA
ASLGQVLDEH GDDAARYVLT ALIDEIHQND DRLVVVIDDW HRVSDTQTIG ALGFLLERGC
HHLQAVVTSW SRAGLPVSKL RIRDELVEID CEALRFDFDE ARSLLNDVDG LLLPDGDVRA
LTTSTDGWVA ALQLAALSLR GGADAASLVS RMSGASEMIG DFLAENVLDS LEPELLEFLL
ATSITERTCG GLASALAAVP RGQAMLEDVE QRGLFLQRID KDPNWFRYHH LFAEFLRHRL
ERDHPDRVYQ LHRVAADWFA EHDHLNEAVD HALASGDAAR AVDLVEQDET NLLEQSKMTT
LLEIVKKLPP RMVVSRARLQ LTLAWTNVLL QRLAPAAAAL KSFETALDRA DLSDVTRADL
RVEADVLRAV GEVFADRVDA IDHLVAEALA RPDSFHPRVG GVAGSLAAFA AVHRFEFDAA
NRLLAWAEPY QEMMGPFAGV YAHCFGGIAA RYTLDIPGAL KNFREAYELG ATAGPHSYAA
RLASALLGEL LCQTGDLAEA TRLVDEGYQL ESEGAGVDIM IARYVTGARV KAKQGDRDAA
IDRLTDGMAA AERLRLPRLA AAVNNERIRL GIAIPQEVAV RLRATRTIRR PPRCDGIATI
IAELDEDSGI RLLSASDSAD DQEQACRRAA ELLAGIDGAQ RPWAALGAQL LLVETLRATG
KIDEANSLAP AVVARCREHG LSGLLTDAGL G
//
