ID U6GI37_EIMAC Unreviewed; 783 AA.
AC U6GI37;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Dipeptidyl peptidase 1 {ECO:0000256|ARBA:ARBA00014709};
DE EC=3.4.14.1 {ECO:0000256|ARBA:ARBA00012059};
DE AltName: Full=Cathepsin C {ECO:0000256|ARBA:ARBA00029779};
DE AltName: Full=Cathepsin J {ECO:0000256|ARBA:ARBA00029762};
DE AltName: Full=Dipeptidyl peptidase I {ECO:0000256|ARBA:ARBA00032961};
DE AltName: Full=Dipeptidyl transferase {ECO:0000256|ARBA:ARBA00030778};
GN ORFNames=EAH_00000990 {ECO:0000313|EMBL:CDI78244.1};
OS Eimeria acervulina (Coccidian parasite).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Eimeriidae; Eimeria.
OX NCBI_TaxID=5801 {ECO:0000313|EMBL:CDI78244.1};
RN [1] {ECO:0000313|EMBL:CDI78244.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Houghton {ECO:0000313|EMBL:CDI78244.1};
RA Reid A.J., Blake D., Billington K., Browne H., Dunn M., Hung S.,
RA Kawahara F., Miranda-Saavedra D., Mourier T., Nagra H., Otto T.D.,
RA Rawlings N., Sanchez A., Sanders M., Subramaniam C., Tay Y., Dear P.,
RA Doerig C., Gruber A., Parkinson J., Shirley M., Wan K.L., Berriman M.,
RA Tomley F., Pain A.;
RT "Genomic analysis of the causative agents of coccidiosis in chickens.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDI78244.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Houghton {ECO:0000313|EMBL:CDI78244.1};
RA Aslett M.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except
CC when Xaa is Arg or Lys, or Yaa or Zaa is Pro.; EC=3.4.14.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000738};
CC -!- COFACTOR:
CC Name=chloride; Xref=ChEBI:CHEBI:17996;
CC Evidence={ECO:0000256|ARBA:ARBA00001923};
CC -!- SUBUNIT: Tetramer of heterotrimers consisting of exclusion domain,
CC heavy- and light chains. {ECO:0000256|ARBA:ARBA00011610}.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; HG670841; CDI78244.1; -; Genomic_DNA.
DR RefSeq; XP_013251513.1; XM_013396059.1.
DR AlphaFoldDB; U6GI37; -.
DR MEROPS; C01.165; -.
DR EnsemblProtists; CDI78244; CDI78244; EAH_00000990.
DR GeneID; 25268169; -.
DR VEuPathDB; ToxoDB:EAH_00000990; -.
DR OMA; TQLGWYS; -.
DR OrthoDB; 5475703at2759; -.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0008239; F:dipeptidyl-peptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 2.40.128.80; Cathepsin C, exclusion domain; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR014882; CathepsinC_exc.
DR InterPro; IPR036496; CathepsinC_exc_dom_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR PANTHER; PTHR12411:SF947; CATHEPSIN O; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08773; CathepsinC_exc; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF75001; Dipeptidyl peptidase I (cathepsin C), exclusion domain; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 433..761
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 375..402
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 783 AA; 84642 MW; CFB08F3BEE696A4C CRC64;
MTPPTSGVIQ SCGSGTPNRN TENLREEIAD PQKYLDKHGG VSTVIEVELT DETMPFTSFF
DSAANPHRHS WQSLVVKDSN NNLGGTWTMV YDEGYEVSLR DRTHLFGLMK YSKNEECPAA
ADGDLEDSNG RTACYTTDST KTQLGWYSSI GVDGSVLSGC FYGEKRLEGE DKGNEALPSS
FVYVRGTASS EGNANKEAAA TTAAANAAAG VGTTPRESAA FDYFLSEDFV NAHNSDEHKS
WIASANSSFI QQHRSILPSL IKYFGHSKVN STDGTEAFPS FLQGASGSSN STSSTAQLYA
CPCKEGEVPE DTRRHVPEKA TQPVLSPQSL VQTAAKTVEI KAHEQEQVLQ QQHVQQQQVE
QQQVEQQQVQ QQQVQQAQQQ QVQQAQQQQV QQQQQVQQQQ QVQQQQQVQQ QQVQQQPVQQ
QQPVQQQQED FELPAAFAWP NPFTDPSFSE APTNQGGCGS CYAISALYAL QQRFAIAAAK
AIDRSNSSSS SENAQEQQGV SPSLLQQVQQ LQKTAVPKLS PQFILSCSFY NQGCNGGLPY
LVGKQAKETG VLGEECMPYV GMDTLTCPVL QPTSSSSSSS SSSSSSTDSF VSFLAADNGS
GSCHGPEQRW FAKSYGYVGG CYECSHCSGE EQIMREIMSN GPVAAAFDAP ASLFTYVSGV
FTAPAYTPHA RVCDSPSATD SRRSSLGGWE YTNHAVTIVG WGETDAAAAT TATPAAAGDS
GKLKYWIVRN TWGSSWGKGG YFLLIRGVNA GGIESQASFI DPDLTRGKGK QLFDSLLAAH
SNK
//
