ID   U6H7Q1_9EIME            Unreviewed;       743 AA.
AC   U6H7Q1;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Transporter, major facilitator family domain containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=EPH_0076120 {ECO:0000313|EMBL:CDI87488.1};
OS   Eimeria praecox.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Eimeriidae; Eimeria.
OX   NCBI_TaxID=51316 {ECO:0000313|EMBL:CDI87488.1};
RN   [1] {ECO:0000313|EMBL:CDI87488.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Houghton {ECO:0000313|EMBL:CDI87488.1};
RA   Reid A.J., Blake D., Billington K., Browne H., Dunn M., Hung S.,
RA   Kawahara F., Miranda-Saavedra D., Mourier T., Nagra H., Otto T.D.,
RA   Rawlings N., Sanchez A., Sanders M., Subramaniam C., Tay Y., Dear P.,
RA   Doerig C., Gruber A., Parkinson J., Shirley M., Wan K.L., Berriman M.,
RA   Tomley F., Pain A.;
RT   "Genomic analysis of the causative agents of coccidiosis in chickens.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDI87488.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Houghton {ECO:0000313|EMBL:CDI87488.1};
RA   Aslett M.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Spinster (TC
CC       2.A.1.49) family. {ECO:0000256|ARBA:ARBA00024338}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HG697605; CDI87488.1; -; Genomic_DNA.
DR   AlphaFoldDB; U6H7Q1; -.
DR   EnsemblProtists; CDI87488; CDI87488; EPH_0076120.
DR   VEuPathDB; ToxoDB:EPH_0076120; -.
DR   OrthoDB; 206375at2759; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR044770; MFS_spinster-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR23505:SF9; PROTEIN, PUTATIVE-RELATED; 1.
DR   PANTHER; PTHR23505; SPINSTER; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        204..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        243..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        276..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        379..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        415..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        448..467
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        626..655
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        661..688
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          172..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          493..577
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..59
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        103..131
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        500..517
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   743 AA;  77605 MW;  F9E8A9D828E7696C CRC64;
     MKAAGPKDDG KNSKTSSGRR ASVGSSEGKT VPAQEECSPA SSVAPCPASS PSPSMAGPAT
     RPSTEECFPL VARGTFPDLE TGGGVPDALA APAPATPVGI SWGGWRRSSN NGSDSSSNRQ
     QQESTPVSLS PIRPELPNEM VGPPAAPQGL RSPADEKLRR WWKLFGLEPQ ALEQQRQEQE
     QRQQEQEQGQ EQPEQQQQHP RVDVRFTSVV FLIFFALEIF VNFDCGAIPC TLSRMADEFR
     LSPTWQGMLG ALPYVGLTLA SPFAGRIFAY WPAKRVLVIS MALNALATLL MVLTVLLPHE
     VLPFASGSST VSTGDEDASG GVDGAAVTGL AAVVASTPAA ESVPDAGSAA AAAAAAVATS
     PRPFFRLPDF SFGDLTPCAL LLLSSRLLVG LTQAPFVIFA PVWVDEFAPP KKAALWMGVM
     QGAAVVGVTV GYLAAGALSV YLGFNWRAAI SFQVFFLCVL TGLVASIPRE YIQTPGGPGA
     PKSLQDAKPA LEHPNDQEQQ QGEEQQQQQQ QKGGEQDPTP RQLPAAEGDC IATGGSTGLS
     PQQPKTGGTH RRKSTDVGRR PPGSSNSPGA WPSSPAAALG SRRHASLKLL LCVRDGIAGV
     LYSMLHRLCA RILSVGWKET GQTPMYMLPV LTLCALLFVV TGVQFWGTIF FASFLGLSPA
     AAVGAFAAVA ATSPVAGVLM GGLTVDAVGG YKTLKGRTRT LVACTVYAAI AVACGGSSLN
     ACTANVRAVQ LLSCSGKKTA VEG
//