ID U6JBG8_ECHGR Unreviewed; 1097 AA.
AC U6JBG8;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=FACT complex subunit {ECO:0000256|RuleBase:RU367052};
GN Name=EGR_09023 {ECO:0000313|WBParaSite:EgrG_001138800};
GN ORFNames=EGR_09023 {ECO:0000313|EMBL:EUB56131.1}, EgrG_001138800
GN {ECO:0000313|EMBL:CDS20690.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB56131.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB56131.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
RN [2] {ECO:0000313|EMBL:CDS20690.1, ECO:0000313|Proteomes:UP000492820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [3] {ECO:0000313|EMBL:CDS20690.1}
RP NUCLEOTIDE SEQUENCE.
RA Aslett M.;
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|WBParaSite:EgrG_001138800}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (OCT-2020) to UniProtKB.
CC -!- FUNCTION: Component of the FACT complex, a general chromatin factor
CC that acts to reorganize nucleosomes. The FACT complex is involved in
CC multiple processes that require DNA as a template such as mRNA
CC elongation, DNA replication and DNA repair. During transcription
CC elongation the FACT complex acts as a histone chaperone that both
CC destabilizes and restores nucleosomal structure. It facilitates the
CC passage of RNA polymerase II and transcription by promoting the
CC dissociation of one histone H2A-H2B dimer from the nucleosome, then
CC subsequently promotes the reestablishment of the nucleosome following
CC the passage of RNA polymerase II. {ECO:0000256|RuleBase:RU367052}.
CC -!- SUBUNIT: Component of the FACT complex.
CC {ECO:0000256|RuleBase:RU367052}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU367052}.
CC Chromosome {ECO:0000256|RuleBase:RU367052}.
CC -!- SIMILARITY: Belongs to the peptidase M24 family. SPT16 subfamily.
CC {ECO:0000256|ARBA:ARBA00010779, ECO:0000256|RuleBase:RU367052}.
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DR EMBL; LK028581; CDS20690.1; -; Genomic_DNA.
DR EMBL; APAU02000128; EUB56131.1; -; Genomic_DNA.
DR AlphaFoldDB; U6JBG8; -.
DR STRING; 6210.U6JBG8; -.
DR EnsemblMetazoa; XM_024498272.1; XP_024347327.1; GeneID_36344738.
DR WBParaSite; EgrG_001138800; EgrG_001138800; EgrG_001138800.
DR OMA; YHINTIP; -.
DR OrthoDB; 169847at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR Proteomes; UP000492820; Unassembled WGS sequence.
DR GO; GO:0035101; C:FACT complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 2.30.29.150; -; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 1.
DR Gene3D; 2.30.29.210; FACT complex subunit Spt16p/Cdc68p; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR029148; FACT-Spt16_Nlobe.
DR InterPro; IPR013953; FACT_Spt16.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR013719; RTT106/SPT16-like_middle_dom.
DR InterPro; IPR040258; Spt16.
DR InterPro; IPR048969; SPT16_C.
DR PANTHER; PTHR13980; CDC68 RELATED; 1.
DR PANTHER; PTHR13980:SF15; FACT COMPLEX SUBUNIT SPT16; 1.
DR Pfam; PF14826; FACT-Spt16_Nlob; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF08512; Rttp106-like_middle; 1.
DR Pfam; PF08644; SPT16; 1.
DR Pfam; PF21091; SPT16_C; 1.
DR SMART; SM01285; FACT-Spt16_Nlob; 1.
DR SMART; SM01287; Rtt106; 1.
DR SMART; SM01286; SPT16; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU367052};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU367052};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU367052};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU367052};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367052};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU367052};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU367052}.
FT DOMAIN 5..165
FT /note="FACT complex subunit Spt16 N-terminal lobe"
FT /evidence="ECO:0000259|SMART:SM01285"
FT DOMAIN 571..731
FT /note="FACT complex subunit Spt16"
FT /evidence="ECO:0000259|SMART:SM01286"
FT DOMAIN 850..940
FT /note="Histone chaperone RTT106/FACT complex subunit SPT16-
FT like middle"
FT /evidence="ECO:0000259|SMART:SM01287"
FT REGION 432..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 966..1097
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..449
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..467
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..1053
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1054..1077
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1078..1097
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1097 AA; 124815 MW; AD6D199BC8AE3282 CRC64;
MTASLDVKLF ASRIKRFYEQ WESPQSNFSD VDAFLVLNGK SEDIYGKTIS TQTYFFGYEL
QETAMLIAKK GITILSSRKK VEFLKPLNSS GVENLTFTLL TRSQDDADKA NVALLAKDFL
SSGNGDKLGV FSKEIERNSE SEFSKSVAST LKSKAKEVVD SSLMFSQFFA AKEEVEVQYL
RKASEVTCIL FSKHLKEKIM DVIDDDKKVS HQSLSDGCQE ALKNRDLTRG YEQEFLEICY
DPIIQSGGSY NLKFSAENDK KPMHFGTIIC SLGVRYRSYC SNVVRTLIVN PNAKQSTYYE
YLHNLLDWAI EQMKPGVVFS NFYNTIVNKV KVDHPELVDK LIRTFGFVTG IEFRDGNYVI
GPKSSAVFRE GMSININLGF QDLLNEEAES EKDKHYALWL GDIVILGLGE NRTNQVLTAA
AKRRPRAVSL YIEEDEEEEE AEGAEDENVD GEGTDAKRRK KEVSGASKDG SRPGFGGGGG
LENGDVDGGP EALGRGHRRA ILDQKTRSEQ TAEEKRLQQR RELFQQLQVS ARNRLSGLKA
DGETGQKAKS NVAYKGAGQM PKEDDVRKLR IFVDKKYETV ILPIFGHPTP FHISTIKNVS
SSIEADYTYL RINFHHPGAV VGPKDASNFQ NPQATFLKEM TYRASNQRHH GETTSPSTNL
NNAYRIIKEV LKKFRSREAE EKERANLVEQ DNLVIEPGKT AFRLRDLYIR PNIVAKRITG
TLEAHSNGFR FTSIRGDKVD ILYNNIKHAF YQPCDGEMII LLHFNLKNAI MYGKKKQDNI
QFYTEVGELT TDLGKSHSRM YDRDDLEAEQ REREMREQIK TAFKTFVERV ENLAKRYNLE
FEVPFRDLGF YGCPLRTTVF MMPTSSCLVS LSEWPPFVIT LEEVELVMFE RVSLSIKTFD
MIFVFKDYRI KPAMITSIPS NSLDHVKEWI LSCDIYYAEG VRSMNWPKLM KTIIDDPEDF
LEQNGWAFIS PDDDDDEDED GFDSDADDES YQPSMDSDAE DDEGGGGGDE DGDGSGSEYN
DDDDDDEEED WDAEEESSAE GSLDSDESEG KDWEELEREA IREDRKREHD DAVRAKKRHR
SPSPRPAKKA KHHHQRR
//
