ID U6KPA1_EIMTE Unreviewed; 436 AA.
AC U6KPA1;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 03-MAY-2023, entry version 27.
DE RecName: Full=tRNA-uridine aminocarboxypropyltransferase {ECO:0000256|ARBA:ARBA00012386};
DE EC=2.5.1.25 {ECO:0000256|ARBA:ARBA00012386};
GN ORFNames=ETH_00012690 {ECO:0000313|EMBL:CDJ37283.1};
OS Eimeria tenella (Coccidian parasite).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Eimeriidae; Eimeria.
OX NCBI_TaxID=5802 {ECO:0000313|EMBL:CDJ37283.1};
RN [1] {ECO:0000313|EMBL:CDJ37283.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Houghton {ECO:0000313|EMBL:CDJ37283.1};
RA Reid A.J., Blake D., Billington K., Browne H., Dunn M., Hung S.,
RA Kawahara F., Miranda-Saavedra D., Mourier T., Nagra H., Otto T.D.,
RA Rawlings N., Sanchez A., Sanders M., Subramaniam C., Tay Y., Dear P.,
RA Doerig C., Gruber A., Parkinson J., Shirley M., Wan K.L., Berriman M.,
RA Tomley F., Pain A.;
RT "Genomic analysis of the causative agents of coccidiosis in chickens.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDJ37283.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Houghton {ECO:0000313|EMBL:CDJ37283.1};
RA Aslett M.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-
CC amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-
CC thioadenosine; Xref=Rhea:RHEA:62432, Rhea:RHEA-COMP:13339, Rhea:RHEA-
CC COMP:16092, ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:65315, ChEBI:CHEBI:82930; EC=2.5.1.25;
CC Evidence={ECO:0000256|ARBA:ARBA00024168};
CC -!- SIMILARITY: Belongs to the TDD superfamily. DTWD2 family.
CC {ECO:0000256|ARBA:ARBA00034489}.
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DR EMBL; HG673751; CDJ37283.1; -; Genomic_DNA.
DR RefSeq; XP_013228121.1; XM_013372667.1.
DR AlphaFoldDB; U6KPA1; -.
DR EnsemblProtists; CDJ37283; CDJ37283; ETH_00012690.
DR GeneID; 25251705; -.
DR VEuPathDB; ToxoDB:ETH2_0850000; -.
DR VEuPathDB; ToxoDB:ETH_00012690; -.
DR OMA; TDIWGAY; -.
DR OrthoDB; 206884at2759; -.
DR GO; GO:0016432; F:tRNA-uridine aminocarboxypropyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR InterPro; IPR005636; DTW.
DR InterPro; IPR039262; DTWD2/TAPT.
DR PANTHER; PTHR21392:SF0; TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 2; 1.
DR PANTHER; PTHR21392; UNCHARACTERIZED; 1.
DR Pfam; PF03942; DTW; 1.
DR SMART; SM01144; DTW; 1.
PE 3: Inferred from homology;
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 109..427
FT /note="DTW"
FT /evidence="ECO:0000259|SMART:SM01144"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 39..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 436 AA; 48451 MW; A82EBB6AC8E83175 CRC64;
MSVAVAGLPP APQETATVRR PPHEIFGTFG LHIAGLAEHQ VPQRRQRRGQ TQRHTYQPMQ
EHQQQEPRGE AYCGQEHHEQ HSRQRLQSHG QHAQQQEGEQ EHQLLGVKRR RVCAECDRPC
SVCYCDIIKG RELNLSDESV SCVVERVLIF MHPLEKKRKS GSVQVLQKLI KGLEVWPHRK
PGCCPFATEQ QQRQQHEQHE LRQEQTVRHE TAAERAVLAD APVEEPKVSA PTNPKDKKEA
KLPQQQQHLC TREGTVLCDT SRMVLLFPTE SSFPLGEGTL PFRLPLTLLA IDGTWKEAKE
MFKATPWLQQ LPAVHLPLLK TEGQADHCGG GGVAAAAVAD LVAADCGSSN SEDTMEAVRV
SGAYGMIRTP PARIAASGGV CTAEAVAEAL SIIGRWARSG SSSLLQIGET TRETLQRIVS
LQQEMRDRNK SRQSTD
//
