ID U6KX56_EIMTE Unreviewed; 905 AA.
AC U6KX56;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=NOL1/NOP2/sun family domain-containing protein, putative {ECO:0000313|EMBL:CDJ42546.1};
GN ORFNames=ETH_00033305 {ECO:0000313|EMBL:CDJ42546.1};
OS Eimeria tenella (Coccidian parasite).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Eimeriidae; Eimeria.
OX NCBI_TaxID=5802 {ECO:0000313|EMBL:CDJ42546.1};
RN [1] {ECO:0000313|EMBL:CDJ42546.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Houghton {ECO:0000313|EMBL:CDJ42546.1};
RA Reid A.J., Blake D., Billington K., Browne H., Dunn M., Hung S.,
RA Kawahara F., Miranda-Saavedra D., Mourier T., Nagra H., Otto T.D.,
RA Rawlings N., Sanchez A., Sanders M., Subramaniam C., Tay Y., Dear P.,
RA Doerig C., Gruber A., Parkinson J., Shirley M., Wan K.L., Berriman M.,
RA Tomley F., Pain A.;
RT "Genomic analysis of the causative agents of coccidiosis in chickens.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDJ42546.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Houghton {ECO:0000313|EMBL:CDJ42546.1};
RA Aslett M.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01023}.
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DR EMBL; HG675723; CDJ42546.1; -; Genomic_DNA.
DR RefSeq; XP_013233296.1; XM_013377842.1.
DR AlphaFoldDB; U6KX56; -.
DR EnsemblProtists; CDJ42546; CDJ42546; ETH_00033305.
DR GeneID; 25255727; -.
DR VEuPathDB; ToxoDB:ETH2_1417500; -.
DR VEuPathDB; ToxoDB:ETH_00033305; -.
DR OMA; LHRCMRF; -.
DR OrthoDB; 197651at2759; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0016428; F:tRNA (cytidine-5-)-methyltransferase activity; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030488; P:tRNA methylation; IEA:UniProt.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR023267; RCMT.
DR InterPro; IPR023270; RCMT_NCL1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22808; NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR22808:SF1; RNA CYTOSINE C(5)-METHYLTRANSFERASE NSUN2; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR PRINTS; PR02008; RCMTFAMILY.
DR PRINTS; PR02011; RCMTNCL1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023}; tRNA processing {ECO:0000256|ARBA:ARBA00022694};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT DOMAIN 52..476
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT REGION 481..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 767..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 366
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 177..183
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 221
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 313
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ SEQUENCE 905 AA; 98421 MW; 7B970E37BC9C0E32 CRC64;
MGRRNPSKKA SQETAGADGD GIWQNGVVRH SAAFESFYKE QKIVPEEEWT AFLECLQSDL
PTAFRVVSIT PFRHYVHKFL QKTLESLQED AAAAASCAAD MRGALKPLEW YKSGYEAFQL
DVSRHVLRTC KPLLSLHKFL VEQSEAATIY RQEAVSMIPA LFLEKEMRGD SLILDMCAAP
GSKTSQLLEA LHQACERERR KNGEEVDGWP PLPTGAIVAN DADVTRSHML VHHLRHLHSP
CLLVTSHAAQ FFPTVFHPLR SEDAATGPAA AATAAPEGAD VLLGSNSNGS SSSSSKEETA
RLVPIQFDGV LCDVPCSGDG TLRKSRALWA SWSPHQGLGC HRLQLQILLR GIKLCKVGGR
IVYSTCAFNP IENEAVVCAA ITKSRGAVEL EDCSGDLPSL RRSPGKSSWR VEWEGRWYDF
FDEVPKTAKA TKKLRQSMFP PVGEPGEPAV PLHRCMRFLP HINNTGGFFV AVLRKVREVP
LAPGSASGDG SRSESNPCGP LDHLEDPEKV QKDIENKREA DGIPEDEDPA AAAAGAPAAR
RFEQIQLDMV GLDWQPELLQ QQQQQLLAQE KRLELDGEAE KDLKPVASEA TAAAAAALQA
SAAAAASSPR CAPPLQPGTS PLALSRAILE QILQLAFETL EIRGEISARK STSPELRAAA
QRLSSHLYFR LKTAESADSG DLESLEGNLG NEDNSERYPR RLFFVSQGVK SLVRAVGASR
YKIINGGCLA FQARARGVYR IAYGAAQWLA PFCELLSGCA ADSPLQQQQQ QQQQQQQLAA
HAGGPADCGL PAESSEAERR RVLHIPCQLL YGLVATKQED RRVPFKKIQE LPCGQALVNS
SCDGSLLFLA KIPQAAGCSS SFTNVAVPAW RGRTNVELML DSNSRLALRS LMEESGVPAT
EGESL
//
